公开(公告)号：US12203077B2

公开(公告)日：2025-01-21

申请号：US16640337

申请日：2018-08-28

Applicant: ShanghaiTech University

Inventor： Jia Chen ,  Xingxu Huang ,  Li Yang ,  Bei Yang ,  Xiaosa Li ,  Ying Wang ,  Yajing Liu

IPC: C12N9/22 ,  C07K14/32 ,  C12N9/78 ,  C12N15/10 ,  C12N15/79

Abstract: Provided are base editors containing a cytidine and a catalytically inactive version of Lachnospiraceae bacterium Cpf1 (LbCpf1). The new base editors have greatly improved editing efficiency and fidelity as compared to Cas9-based base editors, and have different editing windows.