公开(公告)号：US20050101595A1

公开(公告)日：2005-05-12

申请号：US10783887

申请日：2004-02-20

申请人： Shao Song Chu ,  Larry Alegria ,  Ted Bleckman ,  Wesley Chong ,  Rohit Kumar Duvadie ,  Lin Li ,  William Romines ,  Yi Yang

发明人： Shao Song Chu ,  Larry Alegria ,  Ted Bleckman ,  Wesley Chong ,  Rohit Kumar Duvadie ,  Lin Li ,  William Romines ,  Yi Yang

IPC分类号： A61K31/427 ,  A61K31/454 ,  A61K31/55 ,  A61P35/00 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/08 ,  C07D513/04

CPC分类号： C07D417/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/08 ,  C07D513/04

摘要： Aminothiazole compounds with N-containing cycloalkyl at the 2-amino position which are represented by the Formula (I), or a pharmaceutically acceptable prodrug of said compound, pharmaceutically active metabolite or pharmaceutically acceptable salt of said compound, or metabolite thereof, modulate and/or inhibit the cell proliferation and activity of protein kinases. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating malignancies and other disorders by administering effective amounts of such compounds.

摘要翻译： 由式（I）表示的2-氨基位置的含N环烷基的氨基噻唑化合物或所述化合物的药学上可接受的前药，所述化合物或其代谢物的药学活性代谢物或药学上可接受的盐调节和/ 或抑制蛋白激酶的细胞增殖和活性。 本发明还涉及含有这些化合物的药物组合物的治疗或预防用途，以及通过施用有效量的这些化合物来治疗恶性肿瘤和其它病症的方法。

公开(公告)号：US20050239855A1

公开(公告)日：2005-10-27

申请号：US11112423

申请日：2005-04-22

申请人： Siegfried Reich ,  Ted Bleckman ,  Susan Kephart ,  William Romines ,  Michael Wallace

发明人： Siegfried Reich ,  Ted Bleckman ,  Susan Kephart ,  William Romines ,  Michael Wallace

IPC分类号： B22D11/10 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/4375 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/5377 ,  A61P9/00 ,  A61P35/00 ,  A61P43/00 ,  B22D41/50 ,  B22D41/56 ,  C07D231/56 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D471/04 ,  C07D521/00 ,  C07D43/02

CPC分类号： C07D249/08 ,  B22D41/56 ,  C07D231/12 ,  C07D231/56 ,  C07D233/56 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D471/04 ,  C07F7/1804

摘要： Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

公开(公告)号：US20060111322A1

公开(公告)日：2006-05-25

申请号：US11329303

申请日：2006-01-10

申请人： Siegfried Reich ,  Ted Bleckman ,  Susan Kephart ,  William Romines ,  Michael Wallace

发明人： Siegfried Reich ,  Ted Bleckman ,  Susan Kephart ,  William Romines ,  Michael Wallace

IPC分类号： A61K31/695 ,  A61K31/69 ,  C07F5/02

CPC分类号： C07D249/08 ,  B22D41/56 ,  C07D231/12 ,  C07D231/56 ,  C07D233/56 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D471/04 ,  C07F7/1804

摘要： The invention is directed to intermediates useful for making indazole compounds that modulate and/or inhibit cell proliferation.

摘要翻译： 本发明涉及可用于制备调节和/或抑制细胞增殖的吲唑化合物的中间体。