摘要:
Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula (I) wherein X is C═O or SO2, R1 is C1-6 alkyl, R2 is aryl, heteroaryl, aryl, —(CH2)1-3aryl, or —(CH2)1-3heteroaryl, and n is 0 or 1. Methods of using the D3 receptor ligands in the treatment of diseases and conditions wherein modulation of the D3 receptor provides a benefit also are disclosed.
摘要:
Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula: wherein R1 is C1-6 alkyl or C3-6cycloalkyl; or wherein R2 is substituted with one or two halogen(s) or OC1-3alkyl.
摘要:
Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula: wherein R1 is C1-6 alkyl or C3-6cycloalkyl; or wherein R2 is substituted with one or two halogen(s) or OC1-3alkyl.
摘要:
Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula (I) wherein X is C═O or SO2, R1 is C1-6 alkyl, R2 is aryl, heteroaryl, aryl, —(CH2)1-3aryl, or —(CH2)1-3heteroaryl, and n is 0 or 1. Methods of using the D3 receptor ligands in the treatment of diseases and conditions wherein modulation of the D3 receptor provides a benefit also are disclosed.
摘要:
In accordance with one embodiment, a connector for use in a fluid circuit includes a first housing having a hollow interior and an inlet and an outlet. The hollow interior includes first filter elements that are open at first and second ends thereof. The first ends of the first filter elements are in fluid communication with the inlet, while the second ends are in fluid communication with the outlet. The connector also includes a second housing that is in fluid communication with the hollow interior of the first housing. The second housing contains second filter elements that are arranged in a U-shape and are open at first and second ends thereof that are disposed proximate an outlet of the second housing. Fluid is conducted across the first filter elements to gain access to the second housing where the fluid is conducted across the second filter elements in order to exit to the second housing through the outlet.
摘要:
A skylight for installation on a roof of a building is provided. The skylight includes a frame that has a plurality of elements and defines an interior opening. A mounting bracket with a first and second leg is included. The first leg of the mounting bracket is connected to one of the elements of the frame, and the second leg may have a guide structure with at least one opening that extends at an angle with respect to the second leg. The guide structure may be used for securing the mounting bracket and skylight to the roofing structure. The skylight may be provided with a flashing profile that has a rigid section attached to one of the elements of the frame and a flexible section attached to the rigid section. The rigid and flexible sections may extend along the longitudinal lengths of two different elements of the frame. The skylight may be provided with both the mounting bracket and the rigid and flexible flashing sections as discussed above in accordance with various exemplary embodiments of the present invention.
摘要:
A window regulator assembly is easily coupled to a window with the use of a glider retainer block. The glider retainer block is selectively attached to a window lift channel to hold a glider at a desired position within the window lift channel. The glider is coupled to a regulator arm of the window regulator assembly. The glider retainer block is then attached to the window lift channel to hold the glider in the desired position. The window is then clamped to the window lift channel, and the glider retainer block is subsequently detached to allow relative movement between the window lift channel and glider.