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公开(公告)号：US07998489B2
公开(公告)日：2011-08-16
申请号：US12192905
申请日：2008-08-15
申请人： Lance E. Steward , Ester G. Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Shengwen Li , Kei Roger Aoki
发明人： Lance E. Steward , Ester G. Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Shengwen Li , Kei Roger Aoki
CPC分类号： C07K14/33 , C07K2319/33 , C07K2319/55
摘要： The specification discloses modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; polynucleotide molecules encoding modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; and method of producing modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain.
摘要翻译： 该说明书公开了修饰的梭菌毒素，其包含PAR配体结构域，梭菌毒素酶促结构域，梭菌毒素易位结构域和梭菌毒素结合结构域; 编码经修饰的梭菌毒素的多核苷酸分子，其包含PAR配体结构域，梭菌毒素酶促结构域，梭菌毒素易位结构域和梭菌毒素结合结构域; 以及产生包含PAR配体结构域，梭菌毒素酶促结构域，梭菌毒素易位结构域和梭菌毒素结合结构域的修饰梭菌毒素的方法。
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公开(公告)号：US20090048431A1
公开(公告)日：2009-02-19
申请号：US12210770
申请日：2008-09-15
申请人： Lance E. Steward , Fernandez-Salas Ester , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei Roger Aoki
发明人： Lance E. Steward , Fernandez-Salas Ester , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei Roger Aoki
CPC分类号： A61K38/4886 , C07K14/33 , C07K2319/00 , C07K2319/035 , C07K2319/06
摘要： The present invention is directed to multivalent Clostridial toxin comprising more than one binding domain directed to a cell surface molecule of a target cell. Such modified toxins are useful as therapeutic compositions to prevent exocytosis and secretion by the target cell. Conditions in which such compositions man be useful include, without limitation, disorders of the sensory or motor nervous system, acute or chronic pain, cancer, pancreatitis, hyperhydrosis, glandular disorders, viral infections, cystic fibrosis and the like. The invention is also directed to methods of using and administering such a composition, and methods of treating a given condition using such a composition.
摘要翻译： 本发明涉及包含针对靶细胞的细胞表面分子的多于一个结合结构域的多价梭菌毒素。 这样的修饰毒素可用作治疗组合物，以防止靶细胞的胞吐作用和分泌。 这种组合物可用的条件包括但不限于感觉或运动神经系统的疾病，急性或慢性疼痛，癌症，胰腺炎，超氧化，腺体疾病，病毒感染，囊性纤维变性等。 本发明还涉及使用和施用这种组合物的方法，以及使用这种组合物治疗给定病症的方法。
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公开(公告)号：US20090005313A1
公开(公告)日：2009-01-01
申请号：US12192419
申请日：2008-08-15
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K14/33 , A61K38/00 , C12N9/52 , Y02A50/469
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
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公开(公告)号：US20080161226A1
公开(公告)日：2008-07-03
申请号：US11845167
申请日：2007-08-27
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K14/33 , A61K38/00 , C12N9/52 , Y02A50/469
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
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公开(公告)号：US20080138893A1
公开(公告)日：2008-06-12
申请号：US11568834
申请日：2005-06-09
申请人： Lance E. Steward , Marcella A. Gilmore , Ester G. Fernandez-Salas , Shengwen Li , Ronald G. Miller , Kei Roger Aoki
发明人： Lance E. Steward , Marcella A. Gilmore , Ester G. Fernandez-Salas , Shengwen Li , Ronald G. Miller , Kei Roger Aoki
CPC分类号： C07K14/33
摘要： Nucleic acid molecules that comprise modified open reading frames providing increased expression of the encoded active BoNT/E in a heterologous cell, expression constructs and cells comprising such nucleic acid molecules and methods useful for expressing the encoding active BoNT/E from such nucleic acid molecules, expression constructs and cells.
摘要翻译： 包含修饰的开放阅读框的核酸分子提供编码的活性BoNT / E在异源细胞中的表达增加，表达构建体和包含此类核酸分子的细胞和用于从该核酸分子表达编码活性BoNT / E的方法， 表达构建体和细胞。
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6.发明申请Modified Clostridial Toxins With Enhanced Targeting Capabilities For Endogenous Clostridial Toxin Receptor Systems 有权改进的梭菌毒素具有增强的针对内源性梭菌毒素受体系统的靶向能力公开(公告)号：US20080096248A1
公开(公告)日：2008-04-24
申请号：US11908349
申请日：2006-03-14
申请人： Lance Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella Gilmore , Kei Roger Aoki
发明人： Lance Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella Gilmore , Kei Roger Aoki
CPC分类号： C07K14/33 , C07K2319/035 , C07K2319/33 , C07K2319/50 , C07K2319/55
摘要： The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.
摘要翻译： 该说明书公开了修饰梭菌毒素，其包含梭菌毒素酶促结构域，梭菌毒素易位结构域和增强的梭菌毒素结合结构域; 编码这种经修饰的梭菌毒素的多核苷酸分子; 以及生产这种经修饰的梭菌毒素的方法。
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公开(公告)号：US07172764B2
公开(公告)日：2007-02-06
申请号：US10715810
申请日：2003-11-17
申请人： Shengwen Li , Kei Roger Aoki , Lance E. Steward , Joseph Francis
发明人： Shengwen Li , Kei Roger Aoki , Lance E. Steward , Joseph Francis
CPC分类号： B82Y5/00 , A61K38/164 , A61K38/4893 , A61K47/6895 , C12Y304/24069 , Y02A50/469
摘要： The present invention relates to rescue agents for use in the treatments of toxin intoxication—for example botulinum intoxication, which can result from food poisoning, an act of bioterrorism, or from accidental overdose in the course of treatment. In some embodiments, the rescue agents comprise at least one of an inactive botulinum toxin and a modified nontoxic nonhemagglutinin. The present invention also provides for glycosylated active and inactive toxins and methods of using same.
摘要翻译： 本发明涉及用于治疗毒素中毒的拯救剂，例如可能由于食物中毒，生物恐怖行为或在治疗过程中意外过量引起的毒素中毒。 在一些实施方案中，拯救剂包含无活性肉毒杆菌毒素和经修饰的无毒非血凝素中的至少一种。 本发明还提供了糖基化的活性和非活性毒素及其使用方法。
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公开(公告)号：US07825233B2
公开(公告)日：2010-11-02
申请号：US11568834
申请日：2005-06-09
申请人： Lance E. Steward , Marcella A. Gilmore , Ester G. Fernandez-Salas , Shengwen Li , Ronald G. Miller , Kei Roger Aoki
发明人： Lance E. Steward , Marcella A. Gilmore , Ester G. Fernandez-Salas , Shengwen Li , Ronald G. Miller , Kei Roger Aoki
CPC分类号： C07K14/33
摘要： Nucleic acid molecules that comprise modified open reading frames providing increased expression of the encoded active BoNT/E in a heterologous cell, expression constructs and cells comprising such nucleic acid molecules and methods useful for expressing the encoding active BoNT/E from such nucleic acid molecules, expression constructs and cells.
摘要翻译： 包含修饰的开放阅读框的核酸分子提供编码的活性BoNT / E在异源细胞中的表达增加，表达构建体和包含此类核酸分子的细胞和用于从该核酸分子表达编码活性BoNT / E的方法， 表达构建体和细胞。
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公开(公告)号：US07811584B2
公开(公告)日：2010-10-12
申请号：US12210770
申请日：2008-09-15
申请人： Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei Roger Aoki
发明人： Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei Roger Aoki
CPC分类号： A61K38/4886 , C07K14/33 , C07K2319/00 , C07K2319/035 , C07K2319/06
摘要： The present invention is directed to multivalent Clostridial toxin comprising more than one binding domain directed to a cell surface molecule of a target cell. Such modified toxins are useful as therapeutic compositions to prevent exocytosis and secretion by the target cell. Conditions in which such compositions man be useful include, without limitation, disorders of the sensory or motor nervous system, acute or chronic pain, cancer, pancreatitis, hyperhydrosis, glandular disorders, viral infections, cystic fibrosis and the like. The invention is also directed to methods of using and administering such a composition, and methods of treating a given condition using such a composition.
摘要翻译： 本发明涉及包含针对靶细胞的细胞表面分子的多于一个结合结构域的多价梭菌毒素。 这样的修饰毒素可用作治疗组合物，以防止靶细胞的胞吐作用和分泌。 这种组合物可用的条件包括但不限于感觉或运动神经系统的疾病，急性或慢性疼痛，癌症，胰腺炎，超氧化，腺体疾病，病毒感染，囊性纤维变性等。 本发明还涉及使用和施用这种组合物的方法，以及使用这种组合物治疗给定病症的方法。
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公开(公告)号：US20090023901A1
公开(公告)日：2009-01-22
申请号：US12192905
申请日：2008-08-15
申请人： Lance E. Steward , Ester G. Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Shengwen Li , Kei Roger Aoki
发明人： Lance E. Steward , Ester G. Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Shengwen Li , Kei Roger Aoki
CPC分类号： C07K14/33 , C07K2319/33 , C07K2319/55
摘要： The specification discloses modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; polynucleotide molecules encoding modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; and method of producing modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain.
摘要翻译： 该说明书公开了修饰的梭菌毒素，其包含PAR配体结构域，梭菌毒素酶促结构域，梭菌毒素易位结构域和梭菌毒素结合结构域; 编码经修饰的梭菌毒素的多核苷酸分子，其包含PAR配体结构域，梭菌毒素酶促结构域，梭菌毒素易位结构域和梭菌毒素结合结构域; 以及产生包含PAR配体结构域，梭菌毒素酶促结构域，梭菌毒素易位结构域和梭菌毒素结合结构域的修饰梭菌毒素的方法。
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