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34 条记录 (耗时 0.052 秒)

    MULTIVALENT CLOSTRIDIAL TOXINS
    1.
    发明申请
    MULTIVALENT CLOSTRIDIAL TOXINS 有权
    多种封闭性毒素

    公开(公告)号：US20090048431A1

    公开(公告)日：2009-02-19

    申请号：US12210770

    申请日：2008-09-15

    申请人： Lance E. Steward ,  Fernandez-Salas Ester ,  Joseph Francis ,  Shengwen Li ,  Marcella A. Gilmore ,  Kei Roger Aoki

    发明人： Lance E. Steward ,  Fernandez-Salas Ester ,  Joseph Francis ,  Shengwen Li ,  Marcella A. Gilmore ,  Kei Roger Aoki

    IPC分类号： C07K14/00 ,  C07H21/00 ,  C12N15/63 ,  C12P21/00

    CPC分类号： A61K38/4886 ,  C07K14/33 ,  C07K2319/00 ,  C07K2319/035 ,  C07K2319/06

    摘要： The present invention is directed to multivalent Clostridial toxin comprising more than one binding domain directed to a cell surface molecule of a target cell. Such modified toxins are useful as therapeutic compositions to prevent exocytosis and secretion by the target cell. Conditions in which such compositions man be useful include, without limitation, disorders of the sensory or motor nervous system, acute or chronic pain, cancer, pancreatitis, hyperhydrosis, glandular disorders, viral infections, cystic fibrosis and the like. The invention is also directed to methods of using and administering such a composition, and methods of treating a given condition using such a composition.

    摘要翻译： 本发明涉及包含针对靶细胞的细胞表面分子的多于一个结合结构域的多价梭菌毒素。 这样的修饰毒素可用作治疗组合物，以防止靶细胞的胞吐作用和分泌。 这种组合物可用的条件包括但不限于感觉或运动神经系统的疾病，急性或慢性疼痛，癌症，胰腺炎，超氧化，腺体疾病，病毒感染，囊性纤维变性等。 本发明还涉及使用和施用这种组合物的方法，以及使用这种组合物治疗给定病症的方法。

    FRET PROTEASE ASSAYS FOR BOTULINUM SEROTYPE A/E TOXINS
    3.
    发明申请
    FRET PROTEASE ASSAYS FOR BOTULINUM SEROTYPE A/E TOXINS 有权
    用于BOTULINUM SEROTYPE A / E毒素的FRET PROTEASE测定

    公开(公告)号：US20090053746A1

    公开(公告)日：2009-02-26

    申请号：US12042458

    申请日：2008-10-31

    申请人： Lance E. Steward ,  Fernandez-Salas Ester ,  Kei Roger Aoki

    发明人： Lance E. Steward ,  Fernandez-Salas Ester ,  Kei Roger Aoki

    IPC分类号： C12Q1/37

    CPC分类号： G01N33/582

    摘要： The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence that includes a cleavage site, where the cleavage site intervenes between the donor fluorophore and the acceptor and where, under the appropriate conditions, resonance energy transfer is exhibited between the donor fluorophore and the acceptor.

    摘要翻译： 本发明提供了可用于测定任何梭菌毒素（包括所有血清型的肉毒毒素）以及破伤风毒素的蛋白酶活性的梭菌毒素底物。 本发明的梭菌毒素底物含有供体荧光团; 具有与供体荧光团的发射光谱重叠的吸收光谱的受体; 和梭菌毒素识别序列，其包括切割位点，其中切割位点插入供体荧光团和受体之间，并且在适当条件下，在供体荧光团和受体之间显示共振能量转移。

    Multivalent clostridial toxin derivatives and methods of their use
    6.
    发明申请
    Multivalent clostridial toxin derivatives and methods of their use 有权
    多价梭菌毒素衍生物及其使用方法

    公开(公告)号：US20060211619A1

    公开(公告)日：2006-09-21

    申请号：US11376696

    申请日：2006-03-15

    申请人： Lance Steward ,  Fernandez-Salas Ester ,  Joseph Francis ,  Shengwin Li ,  Marcella Gilmore ,  Kei Aoki

    发明人： Lance Steward ,  Fernandez-Salas Ester ,  Joseph Francis ,  Shengwin Li ,  Marcella Gilmore ,  Kei Aoki

    IPC分类号： A61K38/17 ,  C07K14/715 ,  C07K16/28

    CPC分类号： C07K14/33 ,  A61K38/4886 ,  C07K2319/00 ,  C07K2319/035 ,  C07K2319/06

    摘要： The present invention is directed to multivalent Clostridial neurotoxin derivatives having more than one binding domain directed to a cell surface feature of a target cell. Such modified neurotoxins are useful as therapeutic compositions to prevent exocytosis and secretion by the target cell. Conditions in which such compositions man be useful include, without limitation, disorders of the sensory or motor nervous system, acute or chronic pain, cancer, pancreatitis, hyperhydrosis, glandular disorders, viral infections, cystic fibrosis and the like. The invention is also directed to methods of using and administering such a composition, and methods of treating a given condition using such a composition.

    摘要翻译： 本发明涉及具有针对靶细胞的细胞表面特征的多于一个结合结构域的多价梭菌神经毒素衍生物。 这种修饰的神经毒素可用作预防目标细胞胞吐和分泌的治疗组合物。 这些组合物可用的条件包括但不限于感觉或运动神经系统的疾病，急性或慢性疼痛，癌症，胰腺炎，超氧化，腺体疾病，病毒感染，囊性纤维变性等。 本发明还涉及使用和施用这种组合物的方法，以及使用这种组合物治疗给定病症的方法。