公开(公告)号：US5352431A

公开(公告)日：1994-10-04

申请号：US119387

申请日：1993-09-13

申请人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

发明人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

IPC分类号： A61K49/00 ,  A61K49/04 ,  A61K49/08 ,  A61K49/12 ,  A61K51/00 ,  C08B37/08 ,  A61K31/715

CPC分类号： A61K49/085 ,  A61K49/04 ,  A61K49/126 ,  A61K49/128 ,  A61K51/04 ,  A61K51/065 ,  Y10S514/836 ,  Y10T436/24

摘要： There is disclosed an imaging agent for diagnosis comprising a compound composed of a polynuclear type compound of the formula I or II: ##STR1## wherein each X is a hydrogen atom or a bifunctional ligand, at least one of them are bifunctional ligand and m or n is an integer or 1 to 6, and at least one metal ion being coordinated with at least one bifunctional ligand moiety, said metal ion being selected from the group consisting of metal ions having the atomic number of 21-29, 31, 32, 37-39, 42-44, 49 and 56-83.

摘要翻译： 公开了一种用于诊断的成像剂，其包含由式I或II的多核型化合物组成的化合物：其中每个X为氢原子或双官能配体，至少 其中一个是双官能配体，m或n是整数或1-6，并且至少一个金属离子与至少一个双官能配体部分配位，所述金属离子选自具有原子序数的金属离子 21-29,31,32,37-39,42-44,49和56-83段。

公开(公告)号：US5811077A

公开(公告)日：1998-09-22

申请号：US768613

申请日：1996-12-18

申请人： Shigemi Seri ,  Makoto Azuma ,  Kumiko Iwai

发明人： Shigemi Seri ,  Makoto Azuma ,  Kumiko Iwai

IPC分类号： C07D257/02 ,  A61K49/00 ,  A61K49/06 ,  A61K49/04

CPC分类号： A61K49/06

摘要： A gadolinium complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-.alpha.,.alpha.',.alpha.",.alpha."'-tetrakis(methylacetic acid) or its salt, which is useful as a nuclear magnetic resonance imaging agent.

摘要翻译： 1,4,7,10-四氮杂环十二烷-1,4,7,10-α，α'，α“，α” - 四（甲基乙酸）或其盐的钆络合物，其可用作 核磁共振成像剂。

公开(公告)号：US5271924A

公开(公告)日：1993-12-21

申请号：US952992

申请日：1992-09-29

申请人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

发明人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

IPC分类号： A61K49/00 ,  A61K49/04 ,  A61K49/08 ,  A61K49/12 ,  A61K51/00 ,  C08B37/08 ,  G01N24/08 ,  A61K31/715

CPC分类号： A61K49/085 ,  A61K49/04 ,  A61K49/126 ,  A61K49/128 ,  A61K51/04 ,  A61K51/065 ,  Y10S514/836 ,  Y10T436/24

摘要： There is disclosed an imaging agent for diagnosis comprising a compound composed of a polynuclear type compound of the formula I or II: ##STR1## wherein each X is a hydrogen atom or a bifunctional ligand, at least one of them are bifunctional ligand and m or n is an integer of 1 to 6, and at least one metal ion being coordinated with at least one bifunctional ligand moiety, said metal ion being selected from the group consisting of metal ions having the atomic number of 21-29, 31, 32, 37-39, 42-44, 49 and 56-83.

公开(公告)号：US5422095A

公开(公告)日：1995-06-06

申请号：US222226

申请日：1994-04-04

申请人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

发明人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

IPC分类号： A61K49/00 ,  A61K49/04 ,  A61K49/08 ,  A61K49/12 ,  A61K51/00 ,  C08B37/08 ,  A61K51/04

CPC分类号： A61K49/085 ,  A61K49/04 ,  A61K49/126 ,  A61K49/128 ,  A61K51/04 ,  A61K51/065 ,  Y10S514/836 ,  Y10T436/24

摘要： There is disclosed an imaging agent for diagnosis comprising a compound composed of a polynuclear type compound of the formula I or II: ##STR1## wherein each X is a hydrogen atom or a bifunctional ligand, at least one of them are bifunctional ligand and m or n is an integer of 1 to 6, and at least one metal ion being coordinated with at least one bifunctional ligand moiety, said metal ion being selected from the group consisting of metal ions having the atomic number of 21-29, 31, 32, 37-39, 42-44, 49 and 56-83.

摘要翻译： 公开了一种用于诊断的成像剂，其包含由式I或II的多核型化合物组成的化合物：其中每个X为氢原子或双官能配体，至少 其中一个是双官能配体，m或n是1至6的整数，并且至少一个金属离子与至少一个双官能配体部分配位，所述金属离子选自具有原子序数的金属离子 21-29,31,32,37-39,42-44,49和56-83段。

公开(公告)号：US5271929A

公开(公告)日：1993-12-21

申请号：US910546

申请日：1992-07-08

申请人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

发明人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

IPC分类号： A61K49/00 ,  A61K49/08 ,  A61K49/12 ,  C07H15/04 ,  C08B33/08 ,  C08B37/00 ,  G01N24/08 ,  A61K31/715 ,  C07H23/00 ,  C08B35/08

CPC分类号： A61K49/12 ,  A61K49/085 ,  Y10S514/836 ,  Y10T436/24

摘要： There is disclosed a nuclear magnetic resonance imaging agent comprising a complex compound composed of (a) a dialdehyde-saccharide having a molecular weight of from 500 to 10,000, at least one of the constituent monosaccharides of which is oxidation-cleaved, (b) at least one complexing agent which is chemically coupled to an aldehyde group of the dialdehyde-saccharide and (c) a paramagnetic metal ion which is chemically coupled to the complexing agent.