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公开(公告)号：US3957523A
公开(公告)日：1976-05-18
申请号：US455533
申请日：1974-03-28
申请人： Shigeru Ohno , Noboru Hoshi , Fujio Sekigawa
发明人： Shigeru Ohno , Noboru Hoshi , Fujio Sekigawa
CPC分类号： A61K9/5042 , A61K9/2866 , A61K9/5047
摘要： When a mixture comprising 30 to 70% by weight of an enterosoluble cellulose derivative containing a monoester linkage with a polybasic acid, such as, hydroxypropyl methylcellulose phthalate, and 70 to 30% by weight of a digestive fluid-insoluble cellulose derivative, such as, ethylcellulose is used as a coating material for solid medicines, the rate of gradual release of active ingredients of the medicine in the intestinal tracts can be appropriately controlled.
摘要翻译： 含有30〜70重量％含有与多元酸的单酯键的羟基丙基甲基纤维素邻苯二甲酸酯和70〜30重量％的消化不溶性纤维素衍生物的肠溶性纤维素衍生物的混合物， 乙基纤维素用作固体药物的涂层材料，可以适当地控制药物在肠道中的活性成分的逐渐释放的速率。
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公开(公告)号：US4017647A
公开(公告)日：1977-04-12
申请号：US584914
申请日：1975-06-09
申请人： Shigeru Ohno , Noboru Hoshi , Fujio Sekigawa
发明人： Shigeru Ohno , Noboru Hoshi , Fujio Sekigawa
CPC分类号： A61K9/2866 , A61K9/2893 , A61K9/5042
摘要： Enteric coatings are provided on solid pharmaceutical dosage forms by a method comprising covering the dosage froms with an aqueous solution of a polymeric substance having carboxyl groups in the watersoluble salt form and contacting the thus coated dosage forms with an inorganic acid to convert the polymeric substance into the water-insoluble acid form. The coating solution includes no organic solvent, and this method is safe from dangers of fires or explosions and air pollution.
摘要翻译： 通过包括用具有水溶性盐形式的具有羧基的聚合物质的水溶液覆盖剂量的方法提供肠溶衣，并将如此涂覆的剂型与无机酸接触以将聚合物转化为 水不溶性酸形式。 涂层溶液不含有机溶剂，该方法安全避免火灾，爆炸和空气污染等危害。
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公开(公告)号：US4017598A
公开(公告)日：1977-04-12
申请号：US570959
申请日：1975-04-22
申请人： Shigeru Ohno , Noboru Hoshi , Fujio Sekigawa
发明人： Shigeru Ohno , Noboru Hoshi , Fujio Sekigawa
CPC分类号： A61K9/2054
摘要： Methylcellulose with or without the addition of medically active ingredients and other additives is first granulated by a known method into granules of appropriate size and then the granules are blended with a disintegrator and compressed into tablets. The tablets obtained by the method have sufficient hardness and very short disintegration time when taken into the human body in comparison with the poor disintegrability of tablets directly shaped from powdery methylcellulose or a methylcellulose-based mixture of active ingredients. The method is useful for tableting some medicinals of poor tabletability, such as, pancreatin which require large amounts of a binder to be successfully shaped into tablets. Tablets of methylcellulose prepared in accordance with the method can find use as a non-caloried food.
摘要翻译： 首先通过已知方法将具有或不加入医药活性成分和其它添加剂的甲基纤维素制成适当尺寸的颗粒，然后将颗粒与崩解剂混合并压制成片剂。 与由甲基纤维素粉末或甲基纤维素类的活性成分混合物直接成形的片剂的差的崩解性相比，通过该方法获得的片剂具有足够的硬度和非常短的崩解时间。 该方法可用于制备一些不良可制剂性药物，例如需要大量粘合剂成功制成片剂的胰酶。 按照该方法制备的甲基纤维素片可用作非热量食品。
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4.发明授权
公开(公告)号：US4268496A
公开(公告)日：1981-05-19
申请号：US138122
申请日：1980-04-07
申请人： Shigeru Ohno , Fujio Sekigawa
发明人： Shigeru Ohno , Fujio Sekigawa
CPC分类号： A61K9/2853 , A61K9/2866
摘要： Solid pharmaceutical dosage forms of the sustained release type coated with a coating material composed of an aqueous dispersion of a high molecular weight organopolysiloxane and a water-soluble cellulose derivative in the absence of any organic solvent. The solid dosage forms have an excellent property of highly controllable sustained release in a wide range.
摘要翻译： 在不存在任何有机溶剂的情况下，涂覆有由高分子量有机聚硅氧烷的水性分散体和水溶性纤维素衍生物构成的涂料的持续释放型固体药物剂型。 固体剂型在宽范围内具有高度可控持续释放的优异性能。
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公开(公告)号：US4001390A
公开(公告)日：1977-01-04
申请号：US563979
申请日：1975-04-01
申请人： Shigeru Ohno , Fujio Sekigawa , Shokichi Yamagishi
发明人： Shigeru Ohno , Fujio Sekigawa , Shokichi Yamagishi
CPC分类号： A61K9/2866 , A61K9/2886
摘要： Pharmaceutical solid dosage forms are covered with three successive layers of coating, consisting alternately of an undercoat composed substantially of a polymeric substance, a secondary coat composed substantially of a polymeric substance and a pigment, and a finish coat composed substantially of a polymeric substance. Application of these coatings produce economical advantages both in time and labor, and the surfaces of the coated dosage forms are smooth and glossy, and have no cracking.
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6.发明授权
公开(公告)号：US5008113A
公开(公告)日：1991-04-16
申请号：US355110
申请日：1989-05-19
申请人： Hiroyasu Kokubo , Fujio Sekigawa , Tohru Chiba , Yoshiro Onda
发明人： Hiroyasu Kokubo , Fujio Sekigawa , Tohru Chiba , Yoshiro Onda
CPC分类号： A61K9/2866
摘要： Film coated pharmaceutical preparations, which are prepared by overlaying to the outer surface of pharmaceutical preparations, a coating layer comprising at least one member selected from the group consisting of methyl cellulose, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose phthalate, hydroxypropylmethyl cellulose acetate succinate, carboxymethylethyl cellulose and cellulose acetate phthalate, are irradiated with light including ultraviolet rays. Whereby film coated pharmaceutical preparations, the coating layer surface of which are excellent in whiteness, are prepared. Moreover, as a content of a white pigment in corporated into the coating layer of such preparations may be reduced, the stability of such preparations can be enhanced without impairing the strength of the coating layer.
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公开(公告)号：US4287221A
公开(公告)日：1981-09-01
申请号：US109117
申请日：1980-01-02
CPC分类号： A61K9/4891 , A61K9/2866
摘要： The invention provides a novel method for providing entric coating on solid dosage forms using an aqueous coating liquid so that the problems inherent to the use of a coating liquid in an organic solvent can completely be eliminated. The inventive method comprises dispersing a finely divided powder of a hydroxypropylmethylcellulose phthalate in an aqueous medium containing triacetin to give an aqueous coating liquid with which the solid dosage forms are coated, for example, by spraying and dried. It is necessary that the preparation of the coating liquid and the coating procedure with the coating liquid are performed throughout while keeping the temperature of the liquid below 25.degree. C. so as that the particles of the hydroxypropylmethylcellulose phthalate are not dissolved in the medium forming a stable dispersion without adhesive coalescence.
摘要翻译： 本发明提供一种使用水性涂布液在固体剂型上提供中心涂层的新方法，从而可以完全消除在有机溶剂中使用涂布液所固有的问题。 本发明的方法包括将细分散的邻苯二甲酸羟丙基甲基纤维素的粉末分散在含有三醋精的水性介质中，得到例如通过喷雾和干燥涂覆固体剂型的水性涂布液。 必须在保持液体温度低于25℃的同时进行涂布液的制备和涂布液的涂布操作，以使邻苯二甲酸羟丙基甲基纤维素的颗粒不溶解在形成介质的介质中 稳定的分散无粘合剂聚结。
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8.发明申请公开(公告)号：US20060134215A1
公开(公告)日：2006-06-22
申请号：US11294651
申请日：2005-12-05
IPC分类号： A61K9/24
CPC分类号： A61K9/284 , A61K9/2813
摘要： A film coating composition comprises polyvinyl alcohol and talc, and a content of the talc is 50 to 86% by mass based on 100% by mass of the total solid components of the film coating composition. A film consists of the film coating composition, and a tablet comprises the film.
摘要翻译： 薄膜包衣组合物包含聚乙烯醇和滑石，相对于100质量％的薄膜包衣组合物的固体成分，滑石的含量为50〜86质量％。 薄膜由薄膜包衣组合物组成，片剂包含薄膜。
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9.发明授权Coated solid medicament form having releasability in large intestine 失效在大型INTESTINE中具有可释放性的涂层固体药物形式
公开(公告)号：US5217720A
公开(公告)日：1993-06-08
申请号：US726587
申请日：1991-07-08
申请人： Fujio Sekigawa , Yoshiro Onda
发明人： Fujio Sekigawa , Yoshiro Onda
IPC分类号： A61K9/00 , A61K9/28 , A61K9/32 , A61K9/34 , A61K9/36 , A61K9/50 , A61K9/54 , A61K9/62 , A61K47/36 , A61K47/38
CPC分类号： A61K9/5073 , A61K9/286 , A61K9/2886 , A61K9/5036 , Y10S514/96
摘要： A coated solid medicament form suitable for oral administration having reliable releasability of the active ingredient only in the large intestine is proposed. The medicament form is prepared by coating a core solid medicament form containing the active ingredient first with a chitosan having a specific degree of deacetylation and a specific degree of polymerization and then top-coated with a specific enteric-soluble polymer which is a hydroxypropyl methyl cellulose acetate succinate or a hydroxypropyl methyl cellulose hexahydrophthalate. The releasability of the active ingredient only in the large intestine can be more reliable when the core medicament form is, prior to coating with chitosan, provided with an enteric undercoating layer.
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公开(公告)号：US4837033A
公开(公告)日：1989-06-06
申请号：US136864
申请日：1987-12-22
申请人： Hiroyasu Kokubo , Tohru Chiba , Fujio Sekigawa
发明人： Hiroyasu Kokubo , Tohru Chiba , Fujio Sekigawa
IPC分类号： A61K9/50
CPC分类号： A61K9/5047
摘要： Instead of using a uniform aqueous solution of a water-soluble cellulose ether as a coating liquid of solid medicament forms, e.g., granules and tablets, to form a film-forming layer, an aqueous dispersion of a cellulose ether, which is soluble in cold water but insoluble in hot water, is used as a coating liquid at a temperature higher than the solubilization temperature, i.e. the critical point of the solubility behavior, followed by plasticization of the cellulose ether particles with water to cause fusion thereof. The coating liquid is freed from the limitation by the flowability even when the content of the cellulose ether is much higher than in the conventional solution-type coating liquid. In addition to the greatly decreased time taken for forming a coating layer in a desired coating amount, moreover, cellulose ethers having a high degree of polymerization, which cannot be used in the conventional method, can be used so that the resultant film-coating layer is much stronger than otherwise to provide a sustainedly releasing coating layer.
摘要翻译： 代替使用水溶性纤维素醚的均匀水溶液作为固体药物形式的涂布液（例如颗粒剂和片剂）形成成膜层，可溶于冷的纤维素醚的水分散体 水，但不溶于热水，在高于溶解温度的温度即溶解度行为的临界点，作为涂布液使用，随后用水使纤维素醚颗粒增塑以引起熔融。 即使当纤维素醚的含量比常规溶液型涂布液高得多时，涂布液也不受流动性的限制。 此外，除了以所需的涂布量形成涂层所花费的时间大大减少之外，还可以使用不能用于常规方法的具有高聚合度的纤维素醚，从而得到的膜包衣层 比提供持续释放的涂层更强大。
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