公开(公告)号：US4267172A

公开(公告)日：1981-05-12

申请号：US78772

申请日：1979-09-25

申请人： Shigeshi Toyoshima ,  Ryuichi Sato ,  Koichi Ito ,  Toshio Shinohara ,  Masatoshi Arai

发明人： Shigeshi Toyoshima ,  Ryuichi Sato ,  Koichi Ito ,  Toshio Shinohara ,  Masatoshi Arai

IPC分类号： C08K5/00 ,  A01N55/10 ,  A61K31/695 ,  A61P9/12 ,  A61P35/00 ,  C07F9/02 ,  C07F9/141 ,  C08K5/5419 ,  A01N55/00 ,  C07F7/08

CPC分类号： A61K31/695 ,  C07F9/1415

摘要： The present invention presents a novel class of compounds bis(triorganosilylalkyl) phosphites, e.g. bis(trimethylsilylmethyl) phosphite. The compound is readily prepared by the reaction of a corresponding triorganosilyl alkanol with phosphorus trichloride or by the partial hydrolysis of a corresponding tris(triorganosilylalkyl) phosphite with an equimolar amount of water followed by distillation of the reaction mixture.The compound has a remarkable anti-transplanted tumor effectiveness as established by the test with mice as the test animals for preventing the growth of Ehrlich's cancer cells and Sarcoma 180 cells. The compound has very low toxicity when orally administrated.

摘要翻译： 本发明提供了一类新颖的化合物双（三有机甲硅烷基）亚磷酸酯，例如 双（三甲基甲硅烷基甲基）亚磷酸酯。 通过相应的三有机甲硅烷基链烷醇与三氯化磷的反应或通过相应的三（三有机甲硅烷基烷基）亚磷酸酯与等摩尔量的水部分水解然后蒸馏反应混合物来容易地制备该化合物。 该化合物具有显着的抗移植肿瘤效力，其通过用小鼠作为用于预防Ehrlich癌细胞和肉瘤180细胞生长的试验动物的试验建立。 该化合物在口服时具有非常低的毒性。

公开(公告)号：US4349682A

公开(公告)日：1982-09-14

申请号：US186211

申请日：1980-09-11

申请人： Shigeshi Toyoshima ,  Ryuichi Sato ,  Koichi Ito ,  Toshio Shinohara ,  Yasushi Yamamoto

发明人： Shigeshi Toyoshima ,  Ryuichi Sato ,  Koichi Ito ,  Toshio Shinohara ,  Yasushi Yamamoto

IPC分类号： A61K31/695 ,  A61P35/00 ,  C07F7/08 ,  C07F7/10 ,  A61K31/425

CPC分类号： C07F7/0812

摘要： The invention provides a novel compound 2-(3-trimethylsilylpropyl)benzothiazole having remarkable anti-tumor effects or, in particular, inhibiting growth of melanoma cells in test animals. The compound is synthesized by the ring-closing intramolecular dehydration condensation of 2-mercapto-(.gamma.-trimethylsilyl)butyroanilide which in turn is obtained by the dehydrochlorination condensation of 2-aminothiophenol and .gamma.-trimethylsilylbutyryl chloride in a polar solvent in the presence of an acid acceptor.

摘要翻译： 本发明提供了具有显着的抗肿瘤作用或特别是抑制试验动物中黑素瘤细胞生长的新型化合物2-（3-三甲基甲硅烷基丙基）苯并噻唑。 通过2-巯基 - （γ-三甲基甲硅烷基）丁酰苯胺的闭环分子内脱水缩合合成化合物，其通过2-苯基硫酚和γ-三甲基甲硅烷基丁酰氯在极性溶剂中的脱氯化氢缩合获得， 酸受体。

公开(公告)号：US4336251A

公开(公告)日：1982-06-22

申请号：US178359

申请日：1980-08-15

申请人： Shigeshi Toyoshima ,  Ryuichi Sato ,  Koichi Ito ,  Toshio Shinohara ,  Yasushi Yamamoto ,  Shoji Ichinohe

发明人： Shigeshi Toyoshima ,  Ryuichi Sato ,  Koichi Ito ,  Toshio Shinohara ,  Yasushi Yamamoto ,  Shoji Ichinohe

IPC分类号： A61K31/695 ,  A61P9/12 ,  A61P35/00 ,  C07F7/08

CPC分类号： A61K31/695 ,  C07F7/0818

摘要： A novel medicament which is effective as an antihypertensive agent is proposed which contains, as its effective ingredient, an organosilicon compound represented by the general formulaR.sub.3 Si(CH.sub.2).sub.n COOH,where R denotes an alkyl group having from 1 to 6 carbon atoms and n is an integer from 1 to 5 inclusive, or a therapeutically acceptable salt thereof such as a salt with an alkali metal, e.g. sodium or potassium. The effectiveness of the compound, for example, 3-trimethylsilyl butyric acid as well as the sodium and potassium salts thereof is established by the animal test undertaken with hypertensive rats.

摘要翻译： 提出作为抗高血压药有效的新型药物，其含有作为其有效成分的由通式R 3 Si（CH 2）n COOH表示的有机硅化合物，其中R表示具有1至6个碳原子的烷基，n为 1〜5的整数，或其治疗上可接受的盐，例如与碱金属的盐，例如， 钠或钾。 化合物，例如3-三甲基甲硅烷基丁酸及其钠盐和钾盐的有效性是通过用高血压大鼠进行的动物试验建立的。

公开(公告)号：US4328216A

公开(公告)日：1982-05-04

申请号：US102225

申请日：1979-12-10

申请人： Shigeshi Toyoshima ,  Ryuichi Sato ,  Koichi Ito ,  Toshio Shinohara ,  Yasushi Yamamoto ,  Shoji Ichinohe

发明人： Shigeshi Toyoshima ,  Ryuichi Sato ,  Koichi Ito ,  Toshio Shinohara ,  Yasushi Yamamoto ,  Shoji Ichinohe

IPC分类号： A61K31/695 ,  A61P35/00 ,  C07F7/08 ,  C07F7/10

CPC分类号： C07F7/0818

摘要： The invention provides a novel anti-tumor agent highly effective for inhibiting growth of several tumor or cancer cells with low toxicity. The active ingredient contained in the anti-tumor agent is an .omega.-triorganosilyl-substituted linear alkanoic acid anilide which is a hitherto unknown novel compound prepared by the reaction of corresponding acid chloride and aniline.

摘要翻译： 本发明提供了用于抑制几种具有低毒性的肿瘤或癌细胞生长的新型抗肿瘤剂。 包含在抗肿瘤剂中的活性成分是ω-三有机甲硅烷基取代的直链烷酸酰苯胺，它是迄今未知的通过相应的酰氯和苯胺反应制备的新化合物。

公开(公告)号：US4278666A

公开(公告)日：1981-07-14

申请号：US124957

申请日：1980-02-26

申请人： Shigeshi Toyoshima ,  Ryuichi Sato ,  Koichi Ito ,  Toshio Shinohara ,  Yasushi Yamamoto

发明人： Shigeshi Toyoshima ,  Ryuichi Sato ,  Koichi Ito ,  Toshio Shinohara ,  Yasushi Yamamoto

IPC分类号： A61K31/695 ,  A61P35/00 ,  C07F7/08 ,  C07F7/10 ,  A61K31/725 ,  A01N55/00

CPC分类号： C07F7/0818

摘要： The invention provides a novel class of organosilicon compounds and a method for the preparation thereof as well as an anti-tumor agent containing the compound having very remarkable anti-tumor activity but with very low toxicity. The inventive compound is a (trihydrocarbylsilylmethyloxyimino)alkane, which is a silicon-containing oxime compound hitherto not described in any prior art literatures, represented by the general formula R.sup.1.sub.3 Si--CH.sub.2 --O--N.dbd.Y, R.sup.1 is a substituted or unsubstituted monovalent hydrocarbon group having from 1 to 10 carbon atoms and Y is a divalent hydrocarbon group denoted by .dbd.CR.sup.2 R.sup.3 or .dbd.CR.sup.4, R.sup.2 and R.sup.3, which may be identical or different, having the same meaning as R.sup.1 defined above and R.sup.4 being an alkylene group to form a ring structure jointly with the carbon atom directly bonded to the nitrogen atom. Typical examples of the compounds are: 2-(trimethylsilylmethyloxyimino) butane, 2-(trimethylsilylmethyloxyimino)propane, 2-(dimethylphenylsilylmethyloxyimino) butane and trimethylsilylmethyloxyiminocyclohexane.

摘要翻译： 本发明提供了一类新颖的有机硅化合物及其制备方法以及含有非常显着的抗肿瘤活性但毒性非常低的化合物的抗肿瘤剂。 本发明化合物是一种（三烃基甲硅烷基甲氧基亚氨基）烷烃，其是迄今尚未在任何现有技术文献中描述的含硅肟化合物，由通式R 13 Si-CH 2 -ON A = Y表示，R 1是取代或未取代的单价烃基， 1至10个碳原子，Y是由= CR 2 R 3或= CR 4，R 2和R 3表示的二价烃基，其可以相同或不同，具有与上述R 1相同的含义，R 4为形成环的亚烷基 与与氮原子直接键合的碳原子结合。 化合物的典型实例是：2-（三甲基甲硅烷基甲氧基亚氨基）丁烷，2-（三甲基甲硅烷基甲氧基亚氨基）丙烷，2-（二甲基苯基甲硅烷基甲氧基亚氨基）丁烷和三甲基甲硅烷基甲氧基亚氨基环己烷。

公开(公告)号：US4560679A

公开(公告)日：1985-12-24

申请号：US542439

申请日：1983-10-17

申请人： Shigeshi Toyoshima ,  Masayasu Kurono ,  Ryoichi Unno ,  Koichi Ito

发明人： Shigeshi Toyoshima ,  Masayasu Kurono ,  Ryoichi Unno ,  Koichi Ito

IPC分类号： A61K31/695 ,  A61P35/00 ,  C07F7/08 ,  C07F7/10

CPC分类号： C07F7/0812 ,  C07F7/0818

摘要： A novel organosilicon compound represented by a formula ##STR1## wherein A is methylene, carbonyl or sulfonyl group; R, R.sub.1 and R.sub.2 are alkyl group, respectively; R.sub.3 is alkyl, substituted alkyl, alkenyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, pyridyl, substituted pyridyl, furyl, substituted furyl, thienyl, substituted thienyl group or cycloalkyl group together with the substituent A; R.sub.4 is hydrogen, alkyl or alkenyl group; and R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11 and R.sub.12 are hydrogen, alkyl or substituted alkyl, respectively,a non-toxic salt thereof, a process for the preparation of said compound or salt, as well as an antitumor agent comprising as an effective agent at least one of said compound and salt.

摘要翻译： 一种由下式表示的新型有机硅化合物，其中A是亚甲基，羰基或磺酰基; R，R 1和R 2分别是烷基; R 3是烷基，取代的烷基，烯基，苯基，取代的苯基，萘基，取代的萘基，吡啶基，取代的吡啶基，呋喃基，取代的呋喃基，噻吩基，取代的噻吩基或环烷基与取代基A一起; R4是氢，烷基或烯基; R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12分别为氢，烷基或取代的烷基，其无毒盐，制备所述化合物或盐的方法，以及抗肿瘤剂 包括所述化合物和盐中的至少一种作为有效剂。

公开(公告)号：US4778797A

公开(公告)日：1988-10-18

申请号：US773967

申请日：1985-09-09

申请人： Shigeshi Toyoshima ,  Masayasu Kurono ,  Ryoichi Unno ,  Hiromoto Kimura ,  Koichi Ito

发明人： Shigeshi Toyoshima ,  Masayasu Kurono ,  Ryoichi Unno ,  Hiromoto Kimura ,  Koichi Ito

IPC分类号： A61K31/695 ,  A61P35/00 ,  C07F7/08 ,  C07F7/10 ,  C07F7/18

CPC分类号： C07F7/0812

摘要： Novel organo-silicone compounds represented by the formula, ##STR1## wherein R is hydrogen, halogen or alkyl group, R.sup.1, R.sup.2 and R.sup.3 are alkyl group, alkoxy group, phenyl radical, substituted phenyl radical, alkylcarbonyloxy group, or trialkylsilyloxy group, respectively, R.sup.4 is hydrogen, alkyl or alkenyl grup, and m and n are an integer, respectively but those do not represent same integer of 2, when all of R.sup.1, R.sup.2 and R.sup.3 represents methyl radical, a process for the manufacture of the compounds, and an anti-tumor agent which comprises as an effective component, at least one of the compounds.

摘要翻译： 其中R为氢，卤素或烷基，R1，R2和R3分别为烷基，烷氧基，苯基，取代苯基，烷基羰基氧基或三烷基甲硅烷氧基的新型有机硅氧烷化合物， R 4为氢，烷基或链烯基，并且m和n分别为整数，但当R 1，R 2和R 3全部为甲基时，它们不表示2的整数，制备该化合物的方法， 和包含作为有效成分的至少一种化合物的抗肿瘤剂。

公开(公告)号：US08754100B2

公开(公告)日：2014-06-17

申请号：US13138504

申请日：2010-02-24

申请人： Noritaka Kitazawa ,  Daisuke Shinmyo ,  Koichi Ito ,  Nobuaki Sato ,  Daiju Hasegawa ,  Toshiyuki Uemura ,  Toru Watanabe

发明人： Noritaka Kitazawa ,  Daisuke Shinmyo ,  Koichi Ito ,  Nobuaki Sato ,  Daiju Hasegawa ,  Toshiyuki Uemura ,  Toru Watanabe

IPC分类号： A01N43/42 ,  A61K31/44 ,  A01N43/40 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C07D401/00

CPC分类号： C07D417/14 ,  C07D471/04 ,  C07D471/18 ,  C07D487/04 ,  C07D498/04

摘要： A compound represented by the formula [I]: or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a five-membered aromatic heterocyclic group or the like fused with a non-aromatic ring group, which may be substituted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and R2 each represent a C1-6 alkyl group or the like, m represents an integer of 0 to 3, and n represents an integer of 0 to 2, is effective as a therapeutic agent for a disease caused by Aβ.

摘要翻译： 由式[I]表示的化合物或其药理学上可接受的盐或酯，其中环A表示与可被取代的非芳族环基稠合的五元芳族杂环基等，环B表示 可以被取代的苯基等，X1表示单键等，R1和R2各自表示C1-6烷基等，m表示0〜3的整数，n表示 0〜2，作为A＆Bgr引起的疾病的治疗剂是有效的。

公开(公告)号：US08503864B2

公开(公告)日：2013-08-06

申请号：US12109871

申请日：2008-04-25

申请人： Seiji Oura ,  Yuichi Sato ,  Yasunori Arai ,  Osamu Yamagishi ,  Yoshihiro Kataoka ,  Hiroshi Ogasawara ,  Koichi Ito ,  Kentoku Yamaguchi

发明人： Seiji Oura ,  Yuichi Sato ,  Yasunori Arai ,  Osamu Yamagishi ,  Yoshihiro Kataoka ,  Hiroshi Ogasawara ,  Koichi Ito ,  Kentoku Yamaguchi

IPC分类号： G11B27/00 ,  H04N5/93 ,  H04N5/89 ,  H04N5/84 ,  H04N5/92 ,  H04N5/917

CPC分类号： H04N21/41407 ,  H04N19/40 ,  H04N19/503 ,  H04N19/61 ,  H04N21/4334 ,  H04N21/43637 ,  H04N21/4402 ,  H04N21/6131

摘要： In a mobile terminal provided with an encoded data recording function, there is assumed a condition in which a picture frame transmitted from the terminal of a communication partner is reproduced by means of decoding processing and is displayed on a LCD (34) during wireless TV phone communication. In this condition, when a user carries out a picture recording start operation, display picture data reproduced by means of decoding processing in the multimedia processing section (24) to be displayed on the LCD (34) are recorded in a main recording section (26).

公开(公告)号：US20120162706A1

公开(公告)日：2012-06-28

申请号：US13312337

申请日：2011-12-06

申请人： Koichi Ito

发明人： Koichi Ito

IPC分类号： G06F3/12

CPC分类号： G06F3/1215 ,  G06F3/1243 ,  G06F3/1285

摘要： A main body controller provided in an image forming apparatus receives a VDP job from an external computer, and arranges image data of a reusable object and a variable object, which correspond to the VDP job, on a page for printout. An inspection controller performs inspection processing for printed matter for each page, and the main body controller preferentially stores image data of the reusable object, which corresponds to the page for which the printing has been determined to be defective as a result of inspection processing, in a cache unit. The main body controller acquires the reusable object, which corresponds to the page for which the printing has been determined to be defective, from the cache unit, and executes page reprint processing using the acquired reusable object.

摘要翻译： 设置在图像形成装置中的主体控制器从外部计算机接收VDP作业，并将与VDP作业对应的可重复使用对象和可变对象的图像数据排列在打印页面上。 检查控制器对每页的打印物执行检查处理，并且主体控制器优先存储与作为检查处理的结果被确定为有缺陷的页面相对应的可重复使用对象的图像数据， 缓存单元。 主体控制器从高速缓存单元获取与已经确定有缺陷的打印页相对应的可重用对象，并使用所获取的可重用对象执行页面重新打印处理。