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1.发明授权Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes 有权用于生物应用的有机发光半导体纳米晶体探针和用于制造和使用这种探针的方法公开(公告)号：US07314764B2
公开(公告)日：2008-01-01
申请号：US11370656
申请日：2006-03-07
IPC分类号： G01N33/552
CPC分类号： C12Q1/6816 , B82Y15/00 , G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/588 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T436/24 , C12Q2563/107
摘要： A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation—when excited by an electromagnetic radiation source or a particle beam; and (2) an affinity molecule linked to the semiconductor nanocrystal. The semiconductor nanocrystal is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. Exposure of the semiconductor nanocrystal to excitation energy will excite the semiconductor nanocrystal causing the emission of electromagnetic radiation. Further described are processes for respectively: making the luminescent semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.
摘要翻译： 描述能够连接到亲和分子的半导体纳米晶体化合物。 化合物包括（1）当被电磁辐射源或粒子束激发时能够发射电磁辐射和/或吸收能量和/或散射或衍射电磁辐射的半导体纳米晶体; 和（2）与半导体纳米晶体连接的亲和分子。 半导体纳米晶体与亲和分子连接以形成能够与可检测物质结合的半导体纳米晶体探针。 将半导体纳米晶体暴露于激发能将激发导致电磁辐射发射的半导体纳米晶体。 进一步描述的是分别制造发光半导体纳米晶体化合物的方法; 制造半导体纳米晶体探针; 并使用探针来确定材料中可检测物质的存在。
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2.发明授权Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes 有权用于生物应用的有机发光半导体纳米晶体探针和用于制造和使用这种探针的方法公开(公告)号：US06699723B1
公开(公告)日：2004-03-02
申请号：US09865130
申请日：2001-05-24
IPC分类号： G01N33543
CPC分类号： B82Y15/00 , G01N33/54373 , G01N33/588 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T436/24
摘要： A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation—when excited by an electromagnetic radiation source or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The compound is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. Subsequent exposure to excitation energy will excite the semiconductor nanocrystal in the probe, causing the emission of electromagnetic radiation. Further described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.
摘要翻译： 描述能够连接到亲和分子的半导体纳米晶体化合物。 化合物包括（1）当被电磁辐射源或粒子束激发时能够发射电磁辐射和/或吸收能量和/或散射或衍射电磁辐射的半导体纳米晶体; 和（2）至少一种连接剂，其具有连接到半导体纳米晶体的第一部分和能够连接到亲和分子的第二部分。 该化合物与亲和分子连接以形成能够与可检测物质结合的半导体纳米晶体探针。 随后暴露于激发能量将激发探针中的半导体纳米晶体，导致电磁辐射的发射。 进一步描述了分别制造半导体纳米晶体化合物的方法; 制造半导体纳米晶体探针; 并使用探针来确定材料中可检测物质的存在。
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3.发明授权Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes 有权用于生物应用的有机发光半导体纳米晶体探针和用于制造和使用这种探针的方法公开(公告)号：US06423551B1
公开(公告)日：2002-07-23
申请号：US09349833
申请日：1999-07-08
IPC分类号： G01N33543
CPC分类号： C12Q1/6816 , B82Y15/00 , G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/588 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T436/24 , C12Q2563/107
摘要： A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation—when excited by an electromagnetic radiation source or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affity molecule. The compound is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. Subsequent exposure to excitation energy will excite the semiconductor nanocrystal in he probe, causing the emission of electromagnetic radiation. Further described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.
摘要翻译： 描述能够连接到亲和分子的半导体纳米晶体化合物。 化合物包括（1）当被电磁辐射源或粒子束激发时能够发射电磁辐射和/或吸收能量和/或散射或衍射电磁辐射的半导体纳米晶体; 和（2）具有连接到半导体纳米晶体的第一部分和能够连接到亲和分子的第二部分的至少一种连接剂。 该化合物与亲和分子连接以形成能够与可检测物质结合的半导体纳米晶体探针。 随后暴露于激发能将激发探针中的半导体纳米晶体，导致电磁辐射的发射。 进一步描述了分别制造半导体纳米晶体化合物的方法; 制造半导体纳米晶体探针; 并使用探针来确定材料中可检测物质的存在。
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4.发明授权Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes 有权用于生物应用的有机发光半导体纳米晶体探针和用于制造和使用这种探针的方法公开(公告)号：US06927069B2
公开(公告)日：2005-08-09
申请号：US10155759
申请日：2002-05-24
IPC分类号： C12Q1/68 , G01N33/533 , G01N33/542 , G01N33/543 , G01N33/58 , G01Q70/08 , G01Q70/18
CPC分类号： C12Q1/6816 , B82Y15/00 , G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/588 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T436/24 , C12Q2563/107
摘要： A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation—when excited by an electromagnetic radiation source or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The compound is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. Subsequent exposure to excitation energy will excite the semiconductor nanocrystal in the probe causing the emission of electromagnetic radiation. Further described are processes for respectively: making the luminescent semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.
摘要翻译： 描述能够连接到亲和分子的半导体纳米晶体化合物。 化合物包括（1）当被电磁辐射源或粒子束激发时能够发射电磁辐射和/或吸收能量和/或散射或衍射电磁辐射的半导体纳米晶体; 和（2）至少一种连接剂，其具有连接到半导体纳米晶体的第一部分和能够连接到亲和分子的第二部分。 该化合物与亲和分子连接以形成能够与可检测物质结合的半导体纳米晶体探针。 随后暴露于激发能量将激发探针中的半导体纳米晶体，导致电磁辐射的发射。 进一步描述的是分别制造发光半导体纳米晶体化合物的方法; 制造半导体纳米晶体探针; 并使用探针来确定材料中可检测物质的存在。
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公开(公告)号：US07101718B2
公开(公告)日：2006-09-05
申请号：US10918622
申请日：2004-08-12
IPC分类号： G01N33/551
CPC分类号： C12Q1/6816 , B82Y15/00 , G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/588 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T436/24 , C12Q2563/107
摘要： A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation—when excited by an electromagnetic radiation source or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The compound is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. subsequent exposure to excitation energy will excite the semiconductor nanocrystal in the probe causing the emission of electromagnetic radiation. Further described are processes for respectively: making the luminescent semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.
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6.发明授权Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes 失效用于生物应用的有机发光半导体纳米晶体探针和用于制造和使用这种探针的方法
公开(公告)号：US5990479A
公开(公告)日：1999-11-23
申请号：US978450
申请日：1997-11-25
IPC分类号： C12Q1/68 , G01N33/533 , G01N33/542 , G01N33/543 , G01N33/58 , G01Q70/08 , G01Q70/18 , G01N1/30 , G01N21/63
CPC分类号： C12Q1/6816 , B82Y15/00 , G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/588 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T436/24
摘要： A luminescent semiconductor nanocrystal compound is described which is capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation (luminescing) in a narrow wavelength band and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation--when excited by an electromagnetic radiation source (of narrow or broad bandwidth) or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The luminescent semiconductor nanocrystal compound is linked to an affinity molecule to form an organo luminescent semiconductor nanocrystal probe capable of bonding with a detectable substance in a material being analyzed, and capable of emitting electromagnetic radiation in a narrow wavelength band and/or absorbing, scattering, or diffracting energy when excited by an electromagnetic radiation source (of narrow or broad bandwidth) or a particle beam. The probe is stable to repeated exposure to light in the presence of oxygen and/or other radicals.Further described is a process for making the luminescent semiconductor nanocrystal compound and for making the organo luminescent semiconductor nanocrystal probe comprising the luminescent semiconductor nanocrystal compound linked to an affinity molecule capable of bonding to a detectable substance. A process is also described for using the probe to determine the presence of a detectable substance in a material.
摘要翻译： 描述了能够连接到亲和分子的发光半导体纳米晶体化合物。 该化合物包括（1）当被电磁辐射源（窄或宽带宽）激发时，能够发射在窄波段和/或吸收能量的电磁辐射（发光）和/或散射或衍射电磁辐射的半导体纳米晶体 ）或粒子束; 和（2）至少一种连接剂，其具有连接到半导体纳米晶体的第一部分和能够连接到亲和分子的第二部分。 发光半导体纳米晶体化合物与亲和分子连接以形成能够与正在分析的材料中的可检测物质结合的有机发光半导体纳米晶体探针，并且能够发射窄波段的电磁辐射和/或吸收，散射， 或者当被电磁辐射源（窄带或宽带宽）或粒子束激发时被激发的能量。 探针在氧和/或其他自由基存在下重复暴露于光下是稳定的。 进一步描述了制造发光半导体纳米晶体化合物和制备包含与能够与可检测物质结合的亲和分子连接的发光半导体纳米晶体化合物的有机发光半导体纳米晶体探针的方法。 还描述了使用探针来确定材料中可检测物质的存在的方法。
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7.发明申请SEMICONDUCTOR NANOCRYSTAL PROBES FOR BIOLOGICAL APPLICATIONS AND PROCESS FOR MAKING AND USING SUCH PROBES 有权生物应用的半导体纳米级探针和制造和使用这些探针的方法公开(公告)号：US20070111350A1
公开(公告)日：2007-05-17
申请号：US11566998
申请日：2006-12-05
申请人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
发明人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
CPC分类号： H01L33/0062 , B82Y15/00 , C09K11/025 , C09K11/565 , C09K11/883 , C09K11/89 , C09K11/892 , C12Q1/6816 , C12Q2563/107 , G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/588 , H01L33/0083 , Y10T436/141111 , Y10T436/142222
摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.
摘要翻译： 描述了半导体纳米晶体化合物和探针。 该化合物能够连接至一个或多个亲和分子。 化合物包括（1）能够响应于暴露于第一能量提供第二能量的一种或多种半导体纳米晶体，和（2）一种或多种连接剂，其具有连接到所述一种或多种半导体纳米晶体的第一部分 和能够连接到一个或多个亲和分子的第二部分。 一个或多个半导体纳米晶体化合物与一个或多个亲和分子连接以形成半导体纳米晶体探针，该半导体纳米晶体探针能够与正在分析的材料中的一种或多种可检测物质结合，并且能够响应于暴露于第一能量而提供 第二节能量。 还描述了分别制造半导体纳米晶体化合物的方法; 制造半导体纳米晶体探针; 并用探针处理材料。
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8.发明授权Semiconductor nanocrystal probes for biological applications and process for making and using such probes 有权用于生物应用的半导体纳米晶体探针和用于制造和使用这种探针的方法公开(公告)号：US08288153B2
公开(公告)日：2012-10-16
申请号：US12408462
申请日：2009-03-20
申请人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
发明人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
CPC分类号： H01L33/0062 , B82Y15/00 , C09K11/025 , C09K11/565 , C09K11/883 , C09K11/89 , C09K11/892 , C12Q1/6816 , C12Q2563/107 , G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/588 , H01L33/0083 , Y10T436/141111 , Y10T436/142222
摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.
摘要翻译： 描述了半导体纳米晶体化合物和探针。 该化合物能够连接至一个或多个亲和分子。 化合物包括（1）能够响应于暴露于第一能量提供第二能量的一种或多种半导体纳米晶体，和（2）一种或多种连接剂，其具有连接到所述一种或多种半导体纳米晶体的第一部分 和能够连接到一个或多个亲和分子的第二部分。 一个或多个半导体纳米晶体化合物与一个或多个亲和分子连接以形成半导体纳米晶体探针，该半导体纳米晶体探针能够与正在分析的材料中的一种或多种可检测物质结合，并且能够响应于暴露于第一能量而提供 第二节能量。 还描述了分别制造半导体纳米晶体化合物的方法; 制造半导体纳米晶体探针; 并用探针处理材料。
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公开(公告)号：US08288152B2
公开(公告)日：2012-10-16
申请号：US12406651
申请日：2009-03-18
申请人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
发明人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
CPC分类号： H01L33/0062 , B82Y15/00 , C09K11/025 , C09K11/565 , C09K11/883 , C09K11/89 , C09K11/892 , C12Q1/6816 , C12Q2563/107 , G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/588 , H01L33/0083 , Y10T436/141111 , Y10T436/142222
摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.
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10.发明申请SEMICONDUCTOR NANOCRYSTAL PROBES FOR BIOLOGICAL APPLICATIONS AND PROCESS FOR MAKING AND USING SUCH PROBES 有权生物应用的半导体纳米级探针和制造和使用这些探针的方法公开(公告)号：US20100224853A1
公开(公告)日：2010-09-09
申请号：US12408462
申请日：2009-03-20
申请人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
发明人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
IPC分类号： H01L33/04
CPC分类号： H01L33/0062 , B82Y15/00 , C09K11/025 , C09K11/565 , C09K11/883 , C09K11/89 , C09K11/892 , C12Q1/6816 , C12Q2563/107 , G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/588 , H01L33/0083 , Y10T436/141111 , Y10T436/142222
摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.
摘要翻译： 描述了半导体纳米晶体化合物和探针。 该化合物能够连接至一个或多个亲和分子。 化合物包括（1）能够响应于暴露于第一能量提供第二能量的一种或多种半导体纳米晶体，和（2）一种或多种连接剂，其具有连接到所述一种或多种半导体纳米晶体的第一部分 和能够连接到一个或多个亲和分子的第二部分。 一个或多个半导体纳米晶体化合物与一个或多个亲和分子连接以形成半导体纳米晶体探针，该半导体纳米晶体探针能够与正在分析的材料中的一种或多种可检测物质结合，并且能够响应于暴露于第一能量而提供 第二节能量。 还描述了分别制造半导体纳米晶体化合物的方法; 制造半导体纳米晶体探针; 并用探针处理材料。
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