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16 条记录 (耗时 0.021 秒)

    Biodegradable wax composition
    1.
    发明授权
    Biodegradable wax composition 失效
    可生物降解蜡组成

    公开(公告)号：US07989522B2

    公开(公告)日：2011-08-02

    申请号：US10574849

    申请日：2004-10-05

    申请人： Shingo Odajima ,  Nobuyuki Isshiki ,  Hitoshi Otsuka ,  Hidetoshi Oga ,  Minoru Goto

    发明人： Shingo Odajima ,  Nobuyuki Isshiki ,  Hitoshi Otsuka ,  Hidetoshi Oga ,  Minoru Goto

    IPC分类号： C08J3/20

    CPC分类号： C08J3/226 ,  C08J2391/06 ,  C08J2409/00 ,  C08L7/00 ,  C08L9/00 ,  C08L91/06 ,  C08L91/08 ,  C08L2666/08

    摘要： A biodegradable wax composition containing a wax as a main component and also containing a biodegradable polymer and a filler and having a moisture permeability of 3 g·mm/m2·24 hr or less at 40° C. and 90% RH. The wax is preferably present in an amount of 65 to 95% by weight. The biodegradable polymer preferably has a weight average molecular weight of 200,000 or higher. The polymer is preferably polyisoprene or natural rubber and is preferably present in an amount of 5 to 35% by weight.

    摘要翻译： 一种可生物降解的蜡组合物，其含有蜡作为主要成分，并且在40℃，90％RH下具有3g·mm / m 2·24hr以下的透水性，并且还含有生物降解性聚合物和填料。 蜡的含量优选为65〜95重量％。 生物降解性聚合物的重均分子量优选为20万以上。 聚合物优选为聚异戊二烯或天然橡胶，优选以5-35重量％的量存在。

    SUSTAINED RELEASE PREPARATION
    6.
    发明申请
    SUSTAINED RELEASE PREPARATION 审中-公开
    持续发布准备

    公开(公告)号：US20090148480A1

    公开(公告)日：2009-06-11

    申请号：US11995500

    申请日：2006-07-14

    申请人： Nobuyuki Isshiki ,  Noboru Kamada ,  Hideki Takeuchi

    发明人： Nobuyuki Isshiki ,  Noboru Kamada ,  Hideki Takeuchi

    IPC分类号： A61K9/00 ,  A61P1/00

    CPC分类号： A61K9/0065 ,  A61K9/2086 ,  A61K31/341 ,  A61K31/496

    摘要： The invention provides a preparation which shows a satisfactory gastric residence time, has such a size that allows for easy ingestion, can quickly disintegrate after expelled from the stomach, and can be prepared readily in an industrial scale. A gastric retentive preparation having a gastric resident layer and a drug release layer is provided, wherein the gastric resident layer does not disintegrate in the stomach and disintegrates in the intestine. Preferably, the gastric resident layer has a minimum diameter of 7 mm or more as measured after stirring the preparation in the first fluid at 200 rpm at 37° C. for 15 hours under the conditions of the paddle method in the dissolution test in accordance with Japanese Pharmacopoeia and has a maximum diameter of 6 mm or less as measured after further stirring the preparation in the second fluid at 200 rpm at 37° C. for 9 hours under the same conditions.

    摘要翻译： 本发明提供一种显示令人满意的胃停留时间的制剂，具有允许容易摄入的尺寸，可以在从胃排出后迅速崩解，并且可以以工业规模容易地制备。 提供了具有胃滞留层和药物释放层的胃滞留制剂，其中胃停留层在胃中不分解并在肠中分解。 优选地，胃停留层的最小直径为7mm以上，在第一流体中的制剂在200rpm下在37℃下搅拌15小时时，在桨式方法的条件下根据溶出试验按照 日本药典，并且在相同条件下，在第二流体中以200rpm在37℃下进一步搅拌制备9小时后测得的最大直径为6mm或更小。

    Negative electrode material for nonaqueous secondary battery
    8.
    发明授权
    Negative electrode material for nonaqueous secondary battery 失效
    非水系二次电池用负极材料

    公开(公告)号：US06335121B1

    公开(公告)日：2002-01-01

    申请号：US09101381

    申请日：1998-07-09

    申请人： Kuniyuki Nakanishi ,  Nobuyuki Isshiki ,  Atsushi Suzuki ,  Yoshio Kajiura

    发明人： Kuniyuki Nakanishi ,  Nobuyuki Isshiki ,  Atsushi Suzuki ,  Yoshio Kajiura

    IPC分类号： H01M458

    CPC分类号： H01M4/583 ,  C01B32/20 ,  C01P2002/78 ,  C01P2002/82 ,  H01M10/0525

    摘要： Disclosed is an electrode material for secondary battery, wherein the discharge capacity is large and the change in potential during the charge/discharge is small. A carbonaceous material, wherein a value of R (degree of raphitization ), which is defined as a ratio of a Raman spectrum intensity at 1580 cm−1 to a Raman spectrum intensity at 1360 cm−1 in the Raman spectrum analysis, is not more than 4.0 and a length of crystallite (Lc) oriented along a crysatllographic c axis obtained by a wide angle X-ray diffraction method is from 25 to 35 nm, of the electrode material is obtained by calcining a material, which can be carbonized by a heat treatment, in the presence of boron nitride or silicon.

    摘要翻译： 公开了二次电池用电极材料，其放电容量大，充放电时的电位变化小。 在拉曼光谱分析中，被定义为1580cm -1处的拉曼光谱强度与1360cm -1处的拉曼光谱强度的比率的R（拉曼光谱度）的值不是更多的碳质材料 通过广角X射线衍射法获得的沿着crysatllographic c轴定向的微晶长度（Lc）为25〜35nm，电极材料通过煅烧可以被碳化的材料 在氮化硼或硅的存在下进行热处理。

    High-speed processing apparatus and method, signal analyzing system, and measurement apparatus and method
    9.
    发明授权
    High-speed processing apparatus and method, signal analyzing system, and measurement apparatus and method 失效
    高速处理装置及方法，信号分析系统，测量装置及方法

    公开(公告)号：US5537344A

    公开(公告)日：1996-07-16

    申请号：US356250

    申请日：1994-12-22

    申请人： Nobuyuki Isshiki ,  Kimie Sannomiya ,  Takanobu Uchida ,  Toshiharu Numata

    发明人： Nobuyuki Isshiki ,  Kimie Sannomiya ,  Takanobu Uchida ,  Toshiharu Numata

    IPC分类号： H03H17/02 ,  G01R23/16 ,  G06F17/14 ,  G06F17/15 ,  G06F17/10

    CPC分类号： G01R23/16 ,  G06F17/14 ,  G06F17/15 ,  G10L25/27

    摘要： A convolution of input data S.sub.0 and a Gabor function G.sub..alpha.,.omega. is implemented by a processing unit (20) to obtain a wavelet coefficient T.sub.g (2.sup.0,b) of a 0th stage. The input data S.sub.0 is applied to a low-pass filter (30) and is subjected to Gaussian-type filtering so as to be converted into input data S.sub.1 for a 1st stage. The frequency of the high-frequency components of this input data is halved by this filtering. A convolution of this input data S.sub.1 and a Gabor function G.sub..alpha. /3,2.omega./3 is implemented by a processing unit (21) to obtain a wavelet coefficient T.sub.g (2.sup.1,b) of the 1st stage. In the convolution of the 1st stage, the sampling interval is twice that of the 0th stage. Thenceforth, and in similar fashion, the sampling interval in processing operations of subsequent stages is doubled from one stage to the next. As a result, there is no increase in the amount of processing in each stage and a coefficient T.sub.g (2.sup.j,b) can be obtained with identical precision in each stage.

    摘要翻译： PCT No.PCT / JP93 / 00889 Sec。 371日期1994年12月22日第 102（e）日期1994年12月22日PCT Filed 1993年6月29日PCT公布。 第WO94 / 00821号公报 日期：1994年1月6日。输入数据S0和Gabor函数Gα，ω的卷积由处理单元（20）实现，以获得第0级的小波系数Tg（20，b）。 输入数据S0被施加到低通滤波器（30），并进行高斯型滤波，以便转换为第一级的输入数据S1。 该输入数据的高频分量的频率通过该滤波减半。 通过处理单元（21）实现该输入数据S1和Gabor函数Gα/3,2ω/ 3的卷积，以获得第一级的小波系数Tg（21，b）。 在第一阶段的卷积中，采样间隔是第0阶段的两倍。 此后，以类似的方式，后续阶段的处理操作中的采样间隔从一个阶段到另一个阶段加倍。 结果，每个阶段的处理量没有增加，并且在每个阶段可以以相同的精度获得系数Tg（2j，b）。

    GASTRIC RETENTION-TYPE SUSTAINED-RELEASE LEVODOPA PREPARATION
    10.
    发明申请
    GASTRIC RETENTION-TYPE SUSTAINED-RELEASE LEVODOPA PREPARATION 审中-公开
    气体保持型持续释放LEVODOPA制剂

    公开(公告)号：US20100112053A1

    公开(公告)日：2010-05-06

    申请号：US12523117

    申请日：2008-01-10

    申请人： Denichi Momose ,  Nobuyuki Isshiki ,  Noboru Kamada

    发明人： Denichi Momose ,  Nobuyuki Isshiki ,  Noboru Kamada

    IPC分类号： A61K9/24 ,  A61K31/198 ,  A61P25/16 ,  A61K9/20

    CPC分类号： A61K9/0065 ,  A61K9/2086 ,  A61K31/198

    摘要： The present invention is to provide a levodopa preparation which is able to persistently release levodopa in the stomach, has a sufficient gastric residence time, is in an easily ingestible size and is able to be easily manufactured industrially with an object of maintaining a sustained concentration of levodopa in blood. It is a gastric retentive preparation for levodopa, characterized in that, the preparation contains a gastric resident layer showing a sufficient retentive property due to a high mechanical strength in the stomach and showing a good disintegrating property in an intestinal tract in addition to a drug releasing layer containing levodopa.

    摘要翻译： 本发明提供一种能够在胃中持续释放左旋多巴的左旋多巴制剂，具有足够的胃停留时间，容易摄取的尺寸，并且能够容易地在工业上制造，其目的是保持持续浓度 左旋多巴在血液中 它是用于左旋多巴的胃保持制剂，其特征在于，该制剂含有由胃中的高机械强度显示出足够的保留性能的胃停留层，除了药物释放之外还显示出良好的肠道分解性 含有左旋多巴的层。