公开(公告)号：US20100032554A1

公开(公告)日：2010-02-11

申请号：US11992848

申请日：2006-11-01

申请人： Hirohiko Shimizu ,  Jun-ichi Suzuki ,  Takayuki Oku

发明人： Hirohiko Shimizu ,  Jun-ichi Suzuki ,  Takayuki Oku

IPC分类号： H05H3/02

CPC分类号： H05H3/06 ,  G21K1/093 ,  G21K1/16

摘要： A neutron polarization apparatus is provided that provides a neutron beam polarized by an interaction between a spin of a neutron in an incident neutron beam and a magnetic field. The apparatus includes a quadrupole magnet (2) disposed around a passage of a neutron beam, a tubular neutron absorber (3) provided in the quadrupole magnet (2) along am axial direction of the neutron beam, and a solenoid coil (4) disposed at an exit of the quadrupole magnet (2), adiabatically coupling the quadrupole magnetic field produced by the quadrupole magnet (2) and applying a bipolar magnetic field. The neutron polarization apparatus can polarize a neutron with a high polarization unavailable in the prior art.

摘要翻译： 提供一种中子极化装置，其提供通过入射中子束中的中子的自旋与磁场之间的相互作用而偏振的中子束。 该装置包括围绕中子束的通道设置的四极磁体（2），沿着中子束的轴向方向设置在四极磁体（2）中的管状中子吸收体（3），以及设置在电磁线圈 在四极磁体（2）的出口处，绝缘地耦合由四极磁铁（2）产生的四极磁场并施加双极磁场。 中子极化装置可以使现有技术中不可用的高极化的中子偏振。

公开(公告)号：US07450299B2

公开(公告)日：2008-11-11

申请号：US10499968

申请日：2002-12-25

申请人： Yoshiyuki Takizawa ,  Yoshiyuki Takahashi ,  Hirohiko Shimizu ,  Chiko Otani ,  Toshikazu Ebisuzaki

发明人： Yoshiyuki Takizawa ,  Yoshiyuki Takahashi ,  Hirohiko Shimizu ,  Chiko Otani ,  Toshikazu Ebisuzaki

IPC分类号： G02B23/06

CPC分类号： B82Y10/00 ,  G02B23/02 ,  G02B23/06 ,  G21K2201/061

摘要： The light of a broad energy band can be observed by reflecting the light of the broad energy band, for example, the light from the visible light region to the x-ray region at a high reflectance respectively, by a composite telescope including a normal incidence optical system and an oblique incidence optical system. A broadband telescope comprise an oblique incidence optical system unit in which the light is obliquely incident on a surface part for reflecting the incident light, a normal incidence optical system unit in which the light is substantially vertically incident on a surface part for reflecting the incident light, and an analyzer for spectrum analysis of the light reflected by the surface part of the obliquely incidence optical system unit and the light reflected by the surface part of the normal incidence optical system unit.

摘要翻译： 通过复合望远镜，通过将包括正常入射的宽能带的光例如以可见光区域的光反射到高反射率的X射线区域，能够观察到宽能带的光 光学系统和倾斜入射光学系统。 宽带望远镜包括倾斜入射光学系统单元，其中光倾斜地入射在用于反射入射光的表面部分上;法线入射光学系统单元，其中光基本垂直地入射在表面部分上以反射入射光 以及用于对由倾斜入射光学系统单元的表面部分反射的光和由入射光学系统单元的表面部分反射的光进行光谱分析的分析仪。

公开(公告)号：US20060226350A1

公开(公告)日：2006-10-12

申请号：US10516449

申请日：2003-06-03

申请人： Shinya Morita ,  Hitoshi Ohmori ,  Yutaka Yamagata ,  Hirohiko Shimizu ,  Takayuki Oku

发明人： Shinya Morita ,  Hitoshi Ohmori ,  Yutaka Yamagata ,  Hirohiko Shimizu ,  Takayuki Oku

IPC分类号： H05H3/02

CPC分类号： G21K1/06 ,  G21K2201/068

摘要： An apparatus for controlling a neutron beam includes a plurality of columnar prisms 1 that are made of a material having a refractive index of less than 1 for a neutron beam, and are arranged so as to be multi-layered. The columnar prisms 1 each have an approximately right-triangle-shaped section, and are three-dimensionally multi-layered such that respective surfaces 1a, 1b, 1c of the columnar prisms are in parallel to one another. Stick-shaped members 5 are made of the above material, the stick-shaped members 5 are set in a plurality of grooves formed on a jig 6 that have the same shape, and upper surfaces of the grooves are flattened at the same time.

摘要翻译： 用于控制中子束的装置包括多个柱状棱镜1，其由中子束的折射率小于1的材料制成，并且被布置为多层。 柱状棱镜1各自具有近似三角形的截面，并且是三维多层的，使得柱状棱镜的各个表面1a，1b，1c彼此平行。 棒状构件5由上述材料制成，棒状构件5被设置在形成于具有相同形状的夹具6上的多个槽中，并且槽的上表面同时被平坦化。

公开(公告)号：US4024073A

公开(公告)日：1977-05-17

申请号：US551669

申请日：1975-02-21

申请人： Hirohiko Shimizu ,  Hitoshi Ozawa

发明人： Hirohiko Shimizu ,  Hitoshi Ozawa

IPC分类号： A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  B01J13/00 ,  C08B15/10 ,  C08B31/00 ,  C08B33/00 ,  C08B37/00 ,  C08H1/00 ,  C08L77/04 ,  C08L3/02

CPC分类号： A61K47/36 ,  A61K47/34 ,  A61K47/38 ,  A61K9/0019 ,  B01J13/0065 ,  C08B15/10 ,  C08B31/003 ,  C08B33/00 ,  C08B37/00 ,  C08H1/00 ,  C08L77/04

摘要： A novel and stable hydrogel contains a water-soluble polymer containing a chelating agent bound to the polymer chain, and a polyvalent metal ion cross-linking the polymer molecules through the chelating agent. The hydrogel is a carrier for timed release of drugs and medicaments.

摘要翻译： 一种新颖且稳定的水凝胶含有含有与聚合物链结合的螯合剂的水溶性聚合物，多价金属离子通过螯合剂交联聚合物分子。 水凝胶是药物和药物定时释放的载体。

公开(公告)号：US08399414B2

公开(公告)日：2013-03-19

申请号：US10502209

申请日：2003-01-17

申请人： Etsumori Harada ,  Takashi Takeuchi ,  Kenichiro Hayashida ,  Kunio Ando ,  Hirohiko Shimizu

发明人： Etsumori Harada ,  Takashi Takeuchi ,  Kenichiro Hayashida ,  Kunio Ando ,  Hirohiko Shimizu

IPC分类号： A61K38/40 ,  C07K14/79

CPC分类号： A61K9/2866 ,  A61K9/19 ,  A61K9/2013 ,  A61K9/205 ,  A61K9/282 ,  A61K31/485 ,  A61K38/40 ,  A61K2300/00

摘要： The object of this invention is to provide a novel pharmaceutical composition for getting rid of pains and anxiety in patients. This invention relates to a pharmaceutical composition containing lactoferrin as an active ingredient. The composition of this invention is useful for treatment of at least one disease or condition selected from the group consisting of pains, including the phase 1 pain and the phase 2 pain, anxiety and stress. The composition is particularly beneficial to alleviating or getting rid of the pain and anxiety which significantly lower quality of life of patients with end-stage cancer. The composition of this invention is also useful for treatment of pains, including the phase 1 pain and the phase 2 pain, and inflammation which accompany arthritis or diseases in the junctions of bones (e.g. rheumatoid arthritis, osteoarthritis, frozen shoulder, sports injuries such as tennis elbow and baseball shoulder, and low back pain).

摘要翻译： 本发明的目的是提供一种用于消除患者的疼痛和焦虑的新型药物组合物。 本发明涉及含有乳铁蛋白作为活性成分的药物组合物。 本发明的组合物可用于治疗选自疼痛，包括1期疼痛和2期疼痛，焦虑和压力的至少一种疾病或病症。 该组合物特别有利于缓解或消除显着降低终末期癌症患者生活质量的疼痛和焦虑。 本发明的组合物还可用于治疗疼痛，包括1期疼痛和2期疼痛，以及伴随关节炎或骨骼关节疾病的炎症（例如类风湿性关节炎，骨关节炎，冷冻肩部，运动损伤如 网球肘和棒球肩膀，腰痛）。

公开(公告)号：US20080014270A1

公开(公告)日：2008-01-17

申请号：US11832387

申请日：2007-08-01

申请人： Etsumori HARADA ,  Takashi Takeuchi ,  Kunio Ando ,  Hirohiko Shimizu

发明人： Etsumori HARADA ,  Takashi Takeuchi ,  Kunio Ando ,  Hirohiko Shimizu

IPC分类号： A61K9/30 ,  A61K38/40 ,  A61P1/16 ,  A61P3/06 ,  C07K14/79

CPC分类号： A61K38/38 ,  A23L33/19 ,  A23V2002/00 ,  A61K38/40 ,  A23V2250/54248 ,  A23V2250/5424 ,  A23V2250/304 ,  A23V2200/332 ,  A23V2200/328 ,  A61K2300/00

摘要： A pharmaceutical composition is provided having at least one kind to be selected from the group consisting of a lactoferrin group protein having lactoferrin and conalbumin, and an enzymatically decomposed product of the lactoferrin group protein having peptides corresponding to lactoferricin and lactoferricin of conalbumin as an active ingredient. The composition of the present invention can be used as an agent for improving lipid metabolism. Further, it is useful for treating hypercholesterolemia, hyper-neutral lipidemia, hyper-low density lipoprotein (LDL) cholesterolemia, hypo-high density lipoprotein (HDL) cholesterolemia, obesity, fatty liver and cholesterol gallstone and lifestyle-related diseases such as severe obesity, hyperlipidemia, hypertension and type II diabetes. The composition of the present invention can improve basal metabolic rate.

摘要翻译： 提供一种药物组合物，其具有至少一种选自具有乳铁蛋白和氨聚糖蛋白的乳铁蛋白基蛋白和乳铁蛋白基蛋白的酶促分解产物，所述乳铁蛋白基蛋白具有与对照乳头蛋白的乳铁蛋白和乳铁蛋白作为活性成分的肽 。 本发明的组合物可以用作改善脂质代谢的药剂。 此外，它可用于治疗高胆固醇血症，超中性脂质血症，高低密度脂蛋白（LDL）胆固醇血症，低密度脂蛋白（HDL）胆固醇血症，肥胖症，脂肪肝和胆固醇胆结石以及生活方式相关疾病如严重肥胖 ，高脂血症，高血压和II型糖尿病。 本发明的组合物可以改善基础代谢率。

公开(公告)号：US5793564A

公开(公告)日：1998-08-11

申请号：US595484

申请日：1996-02-01

申请人： Hideo Nakase ,  Jo Nakagawa ,  Hirohiko Shimizu ,  Tsuyoshi Umemura ,  Akira Saito

发明人： Hideo Nakase ,  Jo Nakagawa ,  Hirohiko Shimizu ,  Tsuyoshi Umemura ,  Akira Saito

IPC分类号： G11B15/68

CPC分类号： G11B15/6885

摘要： An auto-loading system for recording medium cartridges is provided which permits the simple and reliable operation of rotating the recording medium cartridges between a magazine and a drive. The auto-loading system has a cartridge tray of an elevator which is moved upward and downward between a cartridge port of the drive and a cartridge insertion port and a cartridge ejection port of the magazine within an autoloader body so that a plurality of recording medium cartridges are rotated between the magazine and the drive by the operation of ejecting the recording medium cartridges into the cartridge tray from the cartridge ejection port of the magazine by a first cartridge ejecting mechanism and the operation of ejecting the recording medium cartridges into the cartridge port of the drive or the cartridge insertion port of the magazine from the cartridge tray by a second cartridge ejecting mechanism.

摘要翻译： 提供了用于记录介质盒的自动装载系统，其允许在盒和驱动器之间旋转记录介质盒的简单和可靠的操作。 自动装载系统具有电梯的盒托盘，其在自动装载机主体内在驱动器的盒端口和盒插入口与盒的弹出口之间向上和向下移动，使得多个记录介质盒 通过利用第一盒式排出机构从盒的盒排出口将记录介质盒排出到盒托架中，并且将记录介质盒排出到盒式存储器盒的盒式端口中的操作，在盒和驱动器之间旋转 驱动器或药筒插入口通过第二药筒排出机构从药筒托盘中取出。

公开(公告)号：US06580080B1

公开(公告)日：2003-06-17

申请号：US09520154

申请日：2000-03-07

申请人： Hirohiko Shimizu ,  Takayuki Oku ,  Yuji Kawabata

发明人： Hirohiko Shimizu ,  Takayuki Oku ,  Yuji Kawabata

IPC分类号： G21K106

CPC分类号： B82Y10/00 ,  G01T3/00 ,  G21K1/062 ,  G21K2201/068

摘要： A neutron beam controlling apparatus includes a plurality of multilayered plate members, each having on one or both of its surfaces, one or more minute protruding portions. Each of the protruding portions is a long and narrow protrusion extending in an area-wise direction and having both an inclined surface that is inclined against the beam axis of neutron beam and serves as an incident plane or an outgoing plane for the neutron beam and a surface approximately normal to the plate member.

摘要翻译： 中子束控制装置包括多个多层板构件，每个多层板构件在其一个或两个表面上具有一个或多个微小突出部分。 每个突出部分是沿着区域方向延伸的长而窄的突起，并且具有相对于中子束的束轴倾斜的倾斜表面并且用作中子束的入射面或出射面，并且 大致垂直于板件的表面。

公开(公告)号：US6054708A

公开(公告)日：2000-04-25

申请号：US033720

申请日：1998-03-03

申请人： Hirohiko Shimizu

发明人： Hirohiko Shimizu

IPC分类号： G21K1/08 ,  G21K1/06 ,  G21K5/02 ,  H05H3/06 ,  G01N23/00 ,  G01K1/00

CPC分类号： G21K1/16 ,  H05H3/06 ,  G21K2201/068

摘要： The methods and apparatuses for the control of neutron beams are herewith presented. Through the application of the methods and apparatuses presented one can manipulate various characteristics of neutron beams such as shape, velocity, density, polarization and other traits. In general three sequential operations are performed on the neutron beam, although variations of these steps are described to suit various purposes. First, a neutron beam is passed through a gradient magnet field which causes rotation of the beam in phase space. Second, the spin direction of a neutron beam is reversed through the application of a spin flipper. Third, the neutron beam is compressed in the longitudinal direction of the neutron beam in phase space. This produces a neutron beam having small divergence in phase space. The resultant neutron beam corresponds to a thin dense beam in real space. Variations of this paradigm allow for the manipulation of many characteristics of neutron beams to suit ones purpose.

摘要翻译： 本文介绍了用于控制中子束的方法和装置。 通过应用所提出的方法和装置，可以操纵中子束的各种特性，如形状，速度，密度，极化等特征。 通常，对中子束执行三个顺序操作，尽管描述了这些步骤的变化以适合各种目的。 首先，中子束通过梯度磁场，其导致相位空间中的光束的旋转。 第二，中子束的旋转方向通过应用自旋导板反转。 第三，中子束在相空间中的中子束的纵向被压缩。 这产生了一个在相空间上具有小发散的中子束。 所得到的中子束对应于实际空间中的薄的致密光束。 这种范式的变化允许操纵中子束的许多特征以适应目的。

公开(公告)号：US5442502A

公开(公告)日：1995-08-15

申请号：US834410

申请日：1992-02-12

申请人： Hirohiko Shimizu

发明人： Hirohiko Shimizu

IPC分类号： G11B17/04 ,  G11B17/043 ,  G11B33/12

CPC分类号： G11B17/0434

摘要： A disk drive apparatus has a cassette holder into which a disk cassette is inserted. The cassette holder is obliquely reciprocated between a cassette insert position and a cassette load position as guided by a plurality of inclined guides provided on a pair of side plates of a chassis. In ejecting the disk cassette, the cassette holder is moved directly by an eject lever against a biasing member. Accordingly, it is unnecessary to employ a slide plate for reciprocating the cassette holder.

摘要翻译： 磁盘驱动装置具有磁带盒，磁带盒插入其中。 盒式磁带架在由设置在底盘的一对侧板上的多个倾斜导轨引导的情况下，在盒插入位置和盒装载位置之间倾斜往复运动。 在弹出磁盘盒时，磁带托架通过弹出杆直接移动抵靠偏置构件。 因此，不需要使用用于使盒座往复运动的滑板。