公开(公告)号：US20100065740A1

公开(公告)日：2010-03-18

申请号：US12595393

申请日：2008-03-28

申请人： Shinichi Iwamoto ,  Kei Kodera

发明人： Shinichi Iwamoto ,  Kei Kodera

IPC分类号： H01J49/42

CPC分类号： H01J49/424 ,  H01J49/164 ,  H01J49/4295

摘要： While applying a square wave voltage to the ion electrode (21) so that ions already captured in the ion trap (20) do not disperse, the frequency of the square wave voltage is temporarily increased at the timing when the ions generated in response to the short time irradiation of a laser light reach the ion inlet (25). This decreases the Mathieu parameter qz, and the potential well becomes shallow, which makes it easy for ions to enter the ion trap (20). Although the ions that have been already captured become more likely to disperse, the frequency of the square wave voltage is decreased before they deviate from the stable orbit. Thus, the dispersion of the ions can also be avoided. Accordingly, while the number of captured ions is not decreased, new ions are further added, and thereby the amount of ions can be increased. By performing a mass separation and detection after that, the signal intensity in one mass analysis can be increased. Thereby, the number of repetition of the mass analysis for summing up the mass profiles can be decreased, and the signal intensity can be increased while decreasing the measuring time.

摘要翻译： 当向离子电极（21）施加方波电压时，已经捕获在离子阱（20）中的离子不分散，在响应于该离子阱产生的离子的时刻，方波电压的频率暂时增加 激光的短时间照射到达离子入口（25）。 这降低了Mathieu参数qz，势阱变浅，这使离子容易进入离子阱（20）。 虽然已经被捕获的离子更容易分散，但是在它们偏离稳定轨道之前，方波电压的频率被降低。 因此，也可以避免离子的分散。 因此，虽然捕获离子的数量没有减少，但是进一步添加新离子，从而可以提高离子的量。 通过进行质量分离和检测，可以提高一次质量分析中的信号强度。 因此，可以减少用于求出质量曲线的质量分析的重复次数，并且可以在减少测量时间的同时增加信号强度。

公开(公告)号：US08173961B2

公开(公告)日：2012-05-08

申请号：US12595024

申请日：2008-03-28

申请人： Shinichi Iwamoto ,  Kei Kodera ,  Sadanori Sekiya

发明人： Shinichi Iwamoto ,  Kei Kodera ,  Sadanori Sekiya

IPC分类号： H01J49/42 ,  H01J49/34

CPC分类号： H01J49/164 ,  H01J49/424 ,  H01J49/4295

摘要： While applying a square wave voltage to the ion electrode (21) so that ions already captured in the ion trap (20) do not disperse, the timing of irradiating a laser light for ion generation is controlled in such a manner that ions reach the ion inlet (25) at a predetermined timing of a cycle of the voltage. In the case of a positive ion (cation) for example, the timing of laser light irradiation is adjusted in such a manner that the target ions reach the ion inlet (25) in the low level period of a cycle of the square wave voltage. By injecting ions in addition to the ions already captured in the ion trap (20) in this manner, the amount of ions can be increased, and by performing a mass separation and detection after that, the signal intensity in one mass analysis can be increased. Accordingly, by decreasing the number of repetitions of the mass analysis for summing up mass profiles, the measuring time can be shortened.

摘要翻译： 当向离子电极（21）施加方波电压时，已经捕获在离子阱（20）中的离子不分散，照射激光用于离子产生的时间被控制为使得离子到达离子 入口（25）在电压的周期的预定定时。 例如，在正离子（阳离子）的情况下，以方波电压的周期的低电平期间，目标离子到达离子入口（25）的方式调整激光照射的时刻。 通过以离子阱（20）中已经捕获的离子以外的离子注入离子，可以提高离子量，通过进行质量分离检测，可以增加一次质量分析中的信号强度 。 因此，通过减少用于求出质量曲线的质量分析的重复次数，可以缩短测量时间。

公开(公告)号：US20120119083A1

公开(公告)日：2012-05-17

申请号：US13262214

申请日：2009-03-30

申请人： Kei Kodera ,  Makoto Hazama ,  Shinichi Iwamoto ,  Sadanori Sekiya

发明人： Kei Kodera ,  Makoto Hazama ,  Shinichi Iwamoto ,  Sadanori Sekiya

IPC分类号： H01J49/42

CPC分类号： G01N27/62 ,  G01N27/626

摘要： Ions supplied in the form of a pulse are introduced into an ion trap through an ion entering orifice while a rectangular voltage of a frequency higher than the frequency at which the best trap is accomplished is applied to a ring electrode from a trap voltage generating unit. With this, since a well of a pseudo ion potential is formed in a radial direction in the ion trap, the spread of ions of low m/z values introduced previously is suppressed. A part of ions is introduced into the ion trap, and thereafter the frequency of the rectangular voltage applied to the ring electrode is lowered stepwise to the frequency at which the best trap is accomplished. As a result, the ions of the low m/z values introduced previously can be efficiently trapped, and introduction of ions of high m/z values reaching the ion trap later is not hindered. Consequently, ions of a wide range of m/z values can be trapped in the ion trap with high efficiency

摘要翻译： 以脉冲形式提供的离子通过离子进入孔导入离子阱中，而从陷阱电压产生单元向环形电极施加频率高于完成阱的频率的矩形电压。 由此，由于在离子阱中沿径向形成有假离子电位的阱，所以抑制了以前引入的低m / z值的离子扩散。 一部分离子被引入到离子阱中，此后施加到环形电极的矩形电压的频率逐渐降低到达到最佳阱的频率。 结果，可以有效地捕获先前引入的低m / z值的离子，并且不会妨碍到后来到达离子阱的高m / z值的离子的引入。 因此，m / z值范围宽的离子可以高效地捕获在离子阱中

公开(公告)号：US20100116982A1

公开(公告)日：2010-05-13

申请号：US12595024

申请日：2008-03-28

申请人： Shinichi Iwamoto ,  Kei Kodera ,  Sadanori Sekiya

发明人： Shinichi Iwamoto ,  Kei Kodera ,  Sadanori Sekiya

IPC分类号： H01J49/34

CPC分类号： H01J49/164 ,  H01J49/424 ,  H01J49/4295

摘要： While applying a square wave voltage to the ion electrode (21) so that ions already captured in the ion trap (20) do not disperse, the timing of irradiating a laser light for ion generation is controlled in such a manner that ions reach the ion inlet (25) at a predetermined timing of a cycle of the voltage. In the case of a positive ion (cation) for example, the timing of laser light irradiation is adjusted in such a manner that the target ions reach the ion inlet (25) in the low level period of a cycle of the square wave voltage. By injecting ions in addition to the ions already captured in the ion trap (20) in this manner, the amount of ions can be increased, and by performing a mass separation and detection after that, the signal intensity in one mass analysis can be increased. Accordingly, by decreasing the number of repetitions of the mass analysis for summing up mass profiles, the measuring time can be shortened.

摘要翻译： 当向离子电极（21）施加方波电压时，已经捕获在离子阱（20）中的离子不分散，照射激光用于离子产生的时间被控制为使得离子到达离子 入口（25）在电压的周期的预定定时。 例如，在正离子（阳离子）的情况下，以方波电压的周期的低电平期间，目标离子到达离子入口（25）的方式调整激光照射的时刻。 通过以离子阱（20）中已经捕获的离子以外的离子注入离子，可以提高离子量，通过进行质量分离检测，可以增加一次质量分析中的信号强度 。 因此，通过减少用于求出质量曲线的质量分析的重复次数，可以缩短测量时间。

公开(公告)号：US08022363B2

公开(公告)日：2011-09-20

申请号：US12595393

申请日：2008-03-28

申请人： Shinichi Iwamoto ,  Kei Kodera ,  Sadanori Sekiya

发明人： Shinichi Iwamoto ,  Kei Kodera ,  Sadanori Sekiya

IPC分类号： H01J49/42 ,  H01J3/00

CPC分类号： H01J49/424 ,  H01J49/164 ,  H01J49/4295

摘要： While applying a square wave voltage to the ion electrode (21) so that ions already captured in the ion trap (20) do not disperse, the frequency of the square wave voltage is temporarily increased at the timing when the ions generated in response to the short time irradiation of a laser light reach the ion inlet (25). This decreases the Mathieu parameter qz, and the potential well becomes shallow, which makes it easy for ions to enter the ion trap (20). Although the ions that have been already captured become more likely to disperse, the frequency of the square wave voltage is decreased before they deviate from the stable orbit. Thus, the dispersion of the ions can also be avoided. Accordingly, while the number of captured ions is not decreased, new ions are further added, and thereby the amount of ions can be increased. By performing a mass separation and detection after that, the signal intensity in one mass analysis can be increased. Thereby, the number of repetition of the mass analysis for summing up the mass profiles can be decreased, and the signal intensity can be increased while decreasing the measuring time.

摘要翻译： 当向离子电极（21）施加方波电压时，已经捕获在离子阱（20）中的离子不分散，在响应于该离子阱产生的离子的时刻，方波电压的频率暂时增加 激光的短时间照射到达离子入口（25）。 这降低了Mathieu参数qz，势阱变浅，这使离子容易进入离子阱（20）。 虽然已经被捕获的离子更容易分散，但是在它们偏离稳定轨道之前，方波电压的频率被降低。 因此，也可以避免离子的分散。 因此，虽然捕获离子的数量没有减少，但是进一步添加新离子，从而可以提高离子的量。 通过进行质量分离和检测，可以提高一次质量分析中的信号强度。 因此，可以减少用于求出质量曲线的质量分析的重复次数，并且可以在减少测量时间的同时增加信号强度。