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    Dry Coating using Twin-Screw Kneader
    1.
    发明申请
    Dry Coating using Twin-Screw Kneader 审中-公开
    使用双螺杆捏合机的干涂层

    公开(公告)号：US20090304800A1

    公开(公告)日：2009-12-10

    申请号：US12083628

    申请日：2006-10-12

    申请人： Shinji Fujimoto ,  Toshinobu Uemura ,  Kantaro Kaneko ,  Yoshinobu Fukumori

    发明人： Shinji Fujimoto ,  Toshinobu Uemura ,  Kantaro Kaneko ,  Yoshinobu Fukumori

    IPC分类号： A61K9/14 ,  B05D3/00

    CPC分类号： A61K9/282 ,  A61K9/2893 ,  A61K9/5015 ,  A61K9/5089 ,  B01J2/006 ,  B01J2/10

    摘要： An object of the present invention is to provide a dry coating process that can produce a dry-coated preparation in a large amount. A large amount of dry-coated preparation can be produced more efficiently, than by prior-art processes, by a process in which a material containing core particles and a dry binder (lauric acid, myristic acid, or the like) is kneaded in a twin-screw kneader to produce dry binder particles in which the surfaces of the core particles are dry-coated with the dry binder. Further, a dry coating particle production process in which a material containing core particles, a dry binder, and a coating powder is kneaded in a twin-screw kneader can also produce a large amount of dry-coated preparation more efficiently than prior-art processes.

    摘要翻译： 本发明的目的是提供能够大量生产干涂层制剂的干式涂布方法。 通过以下方法可以比现有技术方法更有效地生产大量的干涂层制剂：其中将包含芯颗粒和干粘合剂（月桂酸，肉豆蔻酸等）的材料在 双螺杆捏合机以产生干粘合剂颗粒，其中芯颗粒的表面用干粘合剂进行干涂层。 此外，在双螺杆捏和机中捏合含有核颗粒，干粘合剂和涂层粉末的材料的干涂层颗粒生产方法也可以比现有技术的方法更有效地产生大量的干涂布制剂 。

    HARD CAPSULE
    6.
    发明申请
    HARD CAPSULE 审中-公开
    硬胶囊

    公开(公告)号：US20120022169A1

    公开(公告)日：2012-01-26

    申请号：US13258703

    申请日：2010-04-02

    申请人： Toshiaki Moriuchi ,  Makoto Taguchi ,  Akane Kojo ,  Hiroyuki Yoshino ,  Yoshinobu Fukumori ,  Yusuke Hayashi

    发明人： Toshiaki Moriuchi ,  Makoto Taguchi ,  Akane Kojo ,  Hiroyuki Yoshino ,  Yoshinobu Fukumori ,  Yusuke Hayashi

    IPC分类号： A61K47/32 ,  A61K47/38

    CPC分类号： A61K9/4866 ,  A61K9/4816

    摘要： The present invention provides a hard capsule that exhibits excellent stability even when filled with a solvent for dissolving a poorly soluble drug, and that achieves improved moldability and drying rate. As such a hard capsule, the present invention provides a hard capsule having a film containing (A) a polymer or copolymer obtained by polymerizing or copolymerizing at least one polymerizable vinyl monomer represented by Formula (1): H2C═C(R1)—COOR2  (1) wherein R1 represents hydrogen or methyl, and R2 represents hydrogen or alkyl having 1 to 4 carbon atoms, in the presence of polyvinyl alcohol and/or a derivative thereof, and (B) at least one water-soluble polymer selected from the group consisting of cellulose polymers, dextrin, and polyvinylpyrrolidone.

    摘要翻译： 本发明提供即使在溶解难溶性药物的溶剂的情况下也显示出优异的稳定性的硬胶囊，并且能够提高成型性和干燥率。 作为这样的硬胶囊，本发明提供一种具有含有（A）通过使至少一种由式（1）表示的可聚合乙烯基单体聚合或共聚得到的聚合物或共聚物的膜的硬胶囊：H 2C≡C（R 1）-COOR 2 （1）其中R 1表示氢或甲基，R 2表示氢或具有1至4个碳原子的烷基，在聚乙烯醇和/或其衍生物的存在下，和（B）至少一种选自以下的水溶性聚合物： 由纤维素聚合物，糊精和聚乙烯吡咯烷酮组成的组。

    Orally administrable time release drug containing products
    7.
    发明授权
    Orally administrable time release drug containing products 失效
    口服给药时间药物含药产品

    公开(公告)号：US6156340A

    公开(公告)日：2000-12-05

    申请号：US624997

    申请日：1996-03-29

    申请人： Christianah Moji Adeyeye ,  Hideki Ichikawa ,  Yoshinobu Fukumori

    发明人： Christianah Moji Adeyeye ,  Hideki Ichikawa ,  Yoshinobu Fukumori

    IPC分类号： A61K9/32 ,  A61K9/50 ,  A61K9/52 ,  A61K9/58

    CPC分类号： A61K9/5078 ,  A61K9/5026

    摘要： A time release orally administrable drug containing product comprising a core, a drug layer attached to the core, and first and second coating layers is disclosed. The first coating layer is directly adjacent to the drug layer, and has a limited permeability to water. The second coating layer is directly adjacent to the first coating, and is more permeable to water than the first layer. A method for using this drug in the treatment of a patient is also disclosed.

    摘要翻译： 公开了一种可释放口服给药的药物产品，包括核心，附着在核心上的药物层，以及第一和第二涂层。 第一涂层直接与药物层相邻，并且对水的渗透性有限。 第二涂层与第一涂层直接相邻，并且比第一层更可渗透水。 还公开了在药物治疗中使用该药物的方法。