公开(公告)号：US10150728B2

公开(公告)日：2018-12-11

申请号：US15029031

申请日：2014-10-17

申请人： Shionogi & Co., Ltd.

发明人： Naotake Kobayashi ,  Kentarou Asahi ,  Yutaka Tomida ,  Masahide Ohdan ,  Masataka Fumoto ,  Yoshikazu Sasaki ,  Kana Kurahashi ,  Takatsugu Inoue ,  Tomomi Urabe ,  Yuji Nishiura ,  Masafumi Iwatsu ,  Keisuke Miyazaki ,  Naoki Ohyabu ,  Toshihiro Wada ,  Manabu Katou

IPC分类号： C07C233/22 ,  C07C233/18 ,  C07C233/31 ,  C07C275/10 ,  C07D403/12 ,  C07D401/14 ,  C07D231/56 ,  C07D401/12 ,  C07D403/14 ,  C07D239/80 ,  C07D413/12 ,  C07D241/18 ,  C07D417/12 ,  C07D261/20 ,  C07D267/14 ,  C07D277/20 ,  C07D277/34 ,  C07D213/64 ,  C07D213/69 ,  C07D263/56 ,  C07D277/64 ,  C07D277/68

摘要： The object of the present invention is to provide novel compounds having ACC2 inhibiting activity. In addition, the object of the present invention is to provide a pharmaceutical composition comprising the compound.A compound of formula (I): wherein R1 is substituted or unsubstituted fused aromatic heterocyclyl etc., ring A is substituted or unsubstituted non-aromatic carbocycle etc., -L1- is —O—(CR6R7)m- etc., -L2- is —O—(CR6R7)n- etc., each R6 and R7 are independently hydrogen, halogen etc., R2 is substituted or unsubstituted alkyl, R3 is hydrogen or substituted or unsubstituted alkyl, R4 is substituted or unsubstituted alkylcarbonyl etc.