公开(公告)号：US20140323722A1

公开(公告)日：2014-10-30

申请号：US14264857

申请日：2014-04-29

申请人： Shionogi & Co., Ltd.

发明人： Koji MASUDA ,  Shiro Kida ,  Naoki Yoshikawa ,  Manabu Katou ,  Terukazu Kato ,  Mado Nakajima ,  Eiichi Kojima ,  Mitsuhiro Yonehara

IPC分类号： C07D417/06 ,  C07D417/14 ,  C07D413/06

CPC分类号： A61K31/423 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/433 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14 ,  C07D513/04

摘要： A compound represented by formula: its pharmaceutically acceptable salt, or a solvate thereof. Ring B is substituted or unsubstituted nitrogen-containing hetero ring, R2 and R3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or substituted or unsubstituted alkyloxy, R2 and R3 taken together may form oxo, R4 is a group represented by the formula: —(CR6R7)n—R8, R6 and R7 are each independently hydrogen, halogen, hydroxy, carboxy, substituted or unsubstituted alkyl or substituted or unsubstituted alkyloxy, R6 and R7 taken together with the adjacent carbon atom to which they are attached may form a substituted or unsubstituted ring, and n is an integer of 0 to 3.

摘要翻译： 由下式表示的化合物：其药学上可接受的盐或其溶剂合物。 环B是取代或未取代的含氮杂环，R2和R3各自独立地为氢，卤素，羟基，氰基，硝基，羧基，取代或未取代的烷基或取代或未取代的烷氧基，R2和R3一起可以形成氧代，R4 是由下式表示的基团： - （CR 6 R 7）n -R 8，R 6和R 7各自独立地为氢，卤素，羟基，羧基，取代或未取代的烷基或取代或未取代的烷氧基，R 6和R 7与相邻碳原子一起 它们所连接的基团可以形成取代或未取代的环，n为0〜3的整数。

公开(公告)号：US10189843B2

公开(公告)日：2019-01-29

申请号：US15120763

申请日：2015-02-26

申请人： The University of Tokyo ,  TOHOKU UNIVERSITY ,  Shionogi & Co., Ltd.

发明人： Tetsuo Nagano ,  Takayoshi Okabe ,  Hirotatsu Kojima ,  Mitsuyasu Kawaguchi ,  Osamu Nureki ,  Ryuichiro Ishitani ,  Hiroshi Nishimasu ,  Junken Aoki ,  Chiaki Fujikoshi ,  Manabu Katou ,  Masahide Odan ,  Nobuyuki Tanaka ,  Yusuke Tateno ,  Junji Yamane

IPC分类号： C07D487/04 ,  C07D491/147 ,  C07D519/00 ,  C07D487/18

摘要： The present invention provides a compound of formula (1), wherein R1, R2, R3, R4a, R4b, R5a and R5b are as defined in the description, which has an autotaxin inhibitory activity, a pharmaceutical composition comprising the compound as an active ingredient, and a method of prevention or treatment of a disease involving autotaxin, which is characterized by administering the compound.

公开(公告)号：US20170107219A1

公开(公告)日：2017-04-20

申请号：US15390933

申请日：2016-12-27

申请人： Shionogi & Co., Ltd.

发明人： Eiichi KOJIMA ,  Keisuke Tonogaki ,  Nobuyuki Tanaka ,  Manabu Katou ,  Akira Ino ,  Masafumi Iwatsu ,  Masahiko Fujioka ,  Yu Hinata ,  Naoki Ohyabu

IPC分类号： C07D471/04 ,  C07F9/6561

CPC分类号： C07D471/04 ,  C07D451/06 ,  C07D519/00 ,  C07F9/6561

摘要： Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen, or substituted or unsubstituted alkyl, R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R1, R2 and R3 are not simultaneously hydrogen, X is a single bond, —S—, —O—, —NR5—, —C(═O)— or the like, R5 is hydrogen, or substituted or unsubstituted alkyl, Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.

公开(公告)号：US10233156B2

公开(公告)日：2019-03-19

申请号：US15557992

申请日：2016-03-30

申请人： Shionogi & Co., Ltd.

发明人： Naoki Ohyabu ,  Kana Kurahashi ,  Yuji Nishiura ,  Manabu Katou ,  Keisuke Miyazaki ,  Yoshikazu Sasaki ,  Toshihiro Wada ,  Masafumi Iwatsu

IPC分类号： C07D235/04 ,  C07D263/56 ,  C07D235/26 ,  C07D403/12 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/506 ,  C07D401/04 ,  C07D401/12 ,  C07D235/28 ,  C07D403/04 ,  C07D405/12 ,  C07D471/04 ,  C07D493/04 ,  A61P3/06 ,  A61P3/08 ,  A61P9/00

摘要： The purpose of the present invention is to provide novel compounds having ACC2 selective inhibitory activity. In addition, the present invention provides a pharmaceutical composition comprising the compound.A compound of Formula: or its pharmaceutically acceptable salt, wherein, R1 is substituted or unsubstituted fused aromatic heterocyclyl represented by Formula: wherein, ring B is 5-membered ring, ring C is 6-membered ring; ring A is substituted or unsubstituted non-aromatic carbocycle or the like; —L1— is —O—(CR6R7)m— or the like; —L2— is —O—(CR6R7)n— or the like; each R6 is independently hydrogen or the like; each R7 is independently hydrogen or the like; each m is independently an integer of 0, 1, 2 or 3; each n is independently an integer of 1, 2 or 3; R2 is substituted or unsubstituted alkyl; R3 is hydrogen or substituted or unsubstituted alkyl; R4 is substituted or unsubstituted alkylcarbonyl or the like.

公开(公告)号：US10150728B2

公开(公告)日：2018-12-11

申请号：US15029031

申请日：2014-10-17

申请人： Shionogi & Co., Ltd.

发明人： Naotake Kobayashi ,  Kentarou Asahi ,  Yutaka Tomida ,  Masahide Ohdan ,  Masataka Fumoto ,  Yoshikazu Sasaki ,  Kana Kurahashi ,  Takatsugu Inoue ,  Tomomi Urabe ,  Yuji Nishiura ,  Masafumi Iwatsu ,  Keisuke Miyazaki ,  Naoki Ohyabu ,  Toshihiro Wada ,  Manabu Katou

IPC分类号： C07C233/22 ,  C07C233/18 ,  C07C233/31 ,  C07C275/10 ,  C07D403/12 ,  C07D401/14 ,  C07D231/56 ,  C07D401/12 ,  C07D403/14 ,  C07D239/80 ,  C07D413/12 ,  C07D241/18 ,  C07D417/12 ,  C07D261/20 ,  C07D267/14 ,  C07D277/20 ,  C07D277/34 ,  C07D213/64 ,  C07D213/69 ,  C07D263/56 ,  C07D277/64 ,  C07D277/68

摘要： The object of the present invention is to provide novel compounds having ACC2 inhibiting activity. In addition, the object of the present invention is to provide a pharmaceutical composition comprising the compound.A compound of formula (I): wherein R1 is substituted or unsubstituted fused aromatic heterocyclyl etc., ring A is substituted or unsubstituted non-aromatic carbocycle etc., -L1- is —O—(CR6R7)m- etc., -L2- is —O—(CR6R7)n- etc., each R6 and R7 are independently hydrogen, halogen etc., R2 is substituted or unsubstituted alkyl, R3 is hydrogen or substituted or unsubstituted alkyl, R4 is substituted or unsubstituted alkylcarbonyl etc.

公开(公告)号：US10093670B2

公开(公告)日：2018-10-09

申请号：US15390933

申请日：2016-12-27

申请人： Shionogi & Co., Ltd.

发明人： Eiichi Kojima ,  Keisuke Tonogaki ,  Nobuyuki Tanaka ,  Manabu Katou ,  Akira Ino ,  Masafumi Iwatsu ,  Masahiko Fujioka ,  Yu Hinata ,  Naoki Ohyabu

IPC分类号： C07D471/04 ,  C07F9/6561 ,  C07D519/00 ,  C07D451/06

摘要： Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen, or substituted or unsubstituted alkyl, R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R1, R2 and R3 are not simultaneously hydrogen, X is a single bond, —S—, —O—, —NR5—, —C(═O)— or the like, R5 is hydrogen, or substituted or unsubstituted alkyl, Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.