公开(公告)号：US4009205A

公开(公告)日：1977-02-22

申请号：US513787

申请日：1974-10-10

申请人： Shiro Kimura ,  Hideo Nagasawa ,  Yasuo Kato ,  Yasuyoshi Nakamura ,  Shoji Miki ,  Yumiko Ishikawa

发明人： Shiro Kimura ,  Hideo Nagasawa ,  Yasuo Kato ,  Yasuyoshi Nakamura ,  Shoji Miki ,  Yumiko Ishikawa

IPC分类号： E04F19/08 ,  C07D209/48 ,  C07C143/75 ,  C07C143/58 ,  C07C143/64 ,  G03C5/30

CPC分类号： C07D209/48

摘要： A process for the preparation of 4-amino-3-methyl-N-substituted or unsubstituted alkylanilines comprising acylating and/or sulfonylating 4-amino-3-methyl-nitro-benzene having the formula (I) ##STR1## with an acylation or sulfonylation agent to obtain a compound having the general formula (II) ##STR2## wherein R.sub.1 represents a hydrogen atom or an acyl group, R.sub.2 represents an acyl group or a sulfonyl group, or R.sub.1 and R.sub.2 can combine as a difunctional acyl group; reducing the nitro group of the compound having the general formula (II) with hydrogen in the presence of a metal hydrogenation catalyst to obtain a compound having the general formula (III) ##STR3## wherein R.sub.1 and R.sub.2 are as above defined; alkylating the amino group of the compound having the general formula (III) with an alkylation agent selected from the group consisting of an alkyl halide, a substituted alkyl halide and an alkylene oxide to obtain a compound having the general formula (IV) ##STR4## wherein R.sub.1 and R.sub.2 are as above defined, R.sub.3 represents an alkyl group or a substituted alkyl group and R.sub.4 represents a hydrogen atom, an alkyl group or a substituted alkyl group; and hydrolyzing the compound having the general formula (IV) to obtain a compound having the general formula (V) ##STR5## wherein R.sub.3 and R.sub.4 are as above defined.

公开(公告)号：US20130273166A1

公开(公告)日：2013-10-17

申请号：US13989865

申请日：2011-12-01

申请人： Karl Kazushige Kawabe ,  Yasumichi Kogai ,  Yumiko Ishikawa ,  Aya Komami

发明人： Karl Kazushige Kawabe ,  Yasumichi Kogai ,  Yumiko Ishikawa ,  Aya Komami

IPC分类号： A61K33/42

CPC分类号： A61K33/42 ,  A61K8/0241 ,  A61K8/24 ,  A61K2800/412 ,  A61Q19/00

摘要： A method for enlarging a breast includes the step of administering to a subject in need thereof a composition that includes a fine particle of calcium phosphate. The fine particle of calcium phosphate may be a fine particle of hydroxyapatite. An average particle size of the fine particle of calcium phosphate is 10 to 1,000 nm. The fine particle of calcium phosphate may be a sintered body. The sintered body may be manufactured by a method including: a mixing step in which a primary particle containing calcium phosphate is mixed with a fusion inhibitor, and a sintering step in which the mixed particle obtained by the mixing step defined above is exposed to a sintering temperature.

摘要翻译： 扩大乳房的方法包括向有需要的受试者施用包含磷酸钙细颗粒的组合物的步骤。 磷酸钙的细颗粒可以是羟基磷灰石的细颗粒。 磷酸钙微粒的平均粒径为10〜1000nm。 磷酸钙的微粒可以是烧结体。 烧结体可以通过以下方法制造：包含磷酸钙的一次粒子与熔融抑制剂混合的混合工序，将烧结工序，将通过上述混合工序得到的混合粒子暴露于烧结体 温度。

公开(公告)号：US20050176739A1

公开(公告)日：2005-08-11

申请号：US11104623

申请日：2005-04-13

申请人： Takuji Hara ,  Yumiko Ishikawa ,  Tetsuya Ryomoto

发明人： Takuji Hara ,  Yumiko Ishikawa ,  Tetsuya Ryomoto

IPC分类号： A61K31/52 ,  A61K31/522 ,  A61P1/14 ,  C07D473/06 ,  C07D473/12

CPC分类号： C07D473/12 ,  A61K31/52 ,  A61K31/522 ,  C07D473/06

摘要： The present invention provides a therapeutic agent for eating disorders, comprising, as an active ingredient, a xanthine derivative represented by formula (I): wherein R1, R2 and R3 independently represent hydrogen, lower alkyl, lower alkenyl or lower alkynyl; R4 represents cycloalkyl, —(CH2)n—R5 or the like; and X1 and X2 independently represent O or S, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供一种进食障碍的治疗剂，其包含作为活性成分的由式（I）表示的黄嘌呤衍生物：其中R 1，R 2和R 2 独立地代表氢，低级烷基，低级烯基或低级炔基; R 4表示环烷基， - （CH 2）n - ， - R 5等; 和X 1和X 2独立地代表O或S或其药学上可接受的盐。