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33 条记录 (耗时 0.038 秒)

    Diazepinedione derivative
    5.
    发明授权
    Diazepinedione derivative 有权
    二氮杂二酮衍生物

    公开(公告)号：US08470814B2

    公开(公告)日：2013-06-25

    申请号：US13148728

    申请日：2010-02-15

    申请人： Shogo Sakuma ,  Toshihiro Takahashi ,  Masatoshi Ushioda ,  Toshiyasu Imai ,  Kazuhide Inoue

    发明人： Shogo Sakuma ,  Toshihiro Takahashi ,  Masatoshi Ushioda ,  Toshiyasu Imai ,  Kazuhide Inoue

    IPC分类号： C07D403/10 ,  A61K31/5513 ,  A61P25/04

    CPC分类号： C07D243/10 ,  C07D403/10 ,  C07D413/10

    摘要： A diazepinedione derivative represented by the formula (I) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: wherein R1 represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like, R2 and R3 represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a halogen atom, or the like, R4 and R5 represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like, and W represents tetrazole or the like.

    摘要翻译： 作为P2X4受体拮抗剂，使用式（I）表示的二氮平二酮衍生物或其药理学上可接受的盐，其中，R1表示氢原子，碳原子数为1〜8的烷基等，R2，R3表示 氢原子，碳原子数1〜8的烷基，卤素原子等，R4和R5表示氢原子，碳原子数1〜8的烷基等，W表示四唑等 。

    DIAZEPINEDIONE DERIVATIVE
    6.
    发明申请
    DIAZEPINEDIONE DERIVATIVE 有权

    公开(公告)号：US20110319610A1

    公开(公告)日：2011-12-29

    申请号：US13148728

    申请日：2010-02-15

    申请人： Shogo Sakuma ,  Toshihiro Takahashi ,  Masatoshi Ushioda ,  Toshiyasu Imai ,  Kazuhide Inoue

    发明人： Shogo Sakuma ,  Toshihiro Takahashi ,  Masatoshi Ushioda ,  Toshiyasu Imai ,  Kazuhide Inoue

    IPC分类号： C07D403/10 ,  C07D413/10

    CPC分类号： C07D243/10 ,  C07D403/10 ,  C07D413/10

    摘要： A diazepinedione derivative represented by the formula (I) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: wherein R1 represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like, R2 and R3 represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a halogen atom, or the like, R4 and R5 represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like, and W represents tetrazole or the like.

    摘要翻译： 作为P2X4受体拮抗剂，使用式（I）表示的二氮平二酮衍生物或其药理学上可接受的盐，其中，R1表示氢原子，碳原子数为1〜8的烷基等，R2，R3表示 氢原子，碳原子数1〜8的烷基，卤素原子等，R4和R5表示氢原子，碳原子数1〜8的烷基等，W表示四唑等 。

    PPAR delta activators
    7.
    发明授权
    PPAR delta activators 有权
    PPARδ激活剂

    公开(公告)号：US06787552B2

    公开(公告)日：2004-09-07

    申请号：US10344496

    申请日：2003-02-11

    申请人： Shogo Sakuma ,  Tsuyoshi Endo ,  Atsushi Tendo ,  Toshihiro Takahashi ,  Shinichi Yoshida ,  Kunio Kobayashi ,  Nobutaka Mochizuki ,  Tomio Yamakawa ,  Takashi Kanda ,  Seiichiro Masui

    发明人： Shogo Sakuma ,  Tsuyoshi Endo ,  Atsushi Tendo ,  Toshihiro Takahashi ,  Shinichi Yoshida ,  Kunio Kobayashi ,  Nobutaka Mochizuki ,  Tomio Yamakawa ,  Takashi Kanda ,  Seiichiro Masui

    IPC分类号： A61K31421

    CPC分类号： C07D413/04 ,  C07D263/32 ,  C07D277/24

    摘要： Compounds of the general formula (I) or salts thereof and activators of PPAR&dgr; (peroxisome proliferator activated receptor &dgr;) containing the compounds or the salts as the active ingredient: wherein R1 and R2 each are hydrogen, C1-8 alkyl, an aryl or heterocyclic group which may be substituted, or the like; A is oxygen, sulfur, or the like; X1 and X2 are each a free valency, oxygen, S(O)p (wherein p is an integer of 0 to 2), C(═O), C(═O)NH, NHC(═O), CH═CH, or the like; Y is optionally substituted C1-8 alkylene; Z is oxygen or sulfur; R3 and R4 are each optionally substituted C1-8 alkyl; and R8 is hydrogen or C1-8 alkyl, with the proviso that when X1 is a free valency, X2 is not O or S(O)p, while when X1 is C(═O)NH, X2 is not a free valency.

    摘要翻译： 通式（I）的化合物或其盐和含有化合物或其盐作为活性成分的PPARdta（过氧化物酶体增殖物活化受体δ）的活化剂：其中R 1和R 2各自为氢，C 1-8 烷基，可被取代的芳基或杂环基等; A是氧，硫等; X 1和X 2各自为自由价，氧，S（O）p（其中p为0至2的整数），C（= O），C（= O）NH，NHC（= O），CH = CH等; Y是任选取代的C 1-8亚烷基; Z是氧或硫; R 3和R 4各自为任选取代的C 1-8烷基; 并且R 8是氢或C 1-8烷基，条件是当X 1是自由价时，X 2不是O或S（O）p，而当X 1是C（O） = O）NH，X 2不是自由价。

    P 2 X 4 RECEPTOR ANTAGONIST
    8.
    发明申请
    P 2 X 4 RECEPTOR ANTAGONIST 有权
    P 2 X 4受体拮抗剂

    公开(公告)号：US20130178625A1

    公开(公告)日：2013-07-11

    申请号：US13811714

    申请日：2011-07-27

    申请人： Masatoshi Ushioda ,  Shogo Sakuma ,  Atsushi Tendo ,  Toshiyasu Imai ,  Kazuhide Inoue

    发明人： Masatoshi Ushioda ,  Shogo Sakuma ,  Atsushi Tendo ,  Toshiyasu Imai ,  Kazuhide Inoue

    IPC分类号： C07D413/10 ,  C07D403/10 ,  C07D401/10 ,  C07D241/38

    CPC分类号： C07D413/10 ,  C07D241/38 ,  C07D241/44 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D409/12

    摘要： A compound having the following formula (II) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: wherein each of R11 and R12 is hydrogen, C1-8 alkyl or the like; R13 is hydrogen, C1-8 alkyl or the like; R14 is hydrogen, C1-8 alkyl, C1-8 alkoxy, C1-8 alkyl having 1-3 halogens, C1-8 hydroxyalkyl, halogen, hydroxyl, nitro, cyano, amino, C1-8 alkylamino, benzenesulfonylamino optionally having a substituent, a heterocyclic group optionally having a substituent or the like; and the condensed ring consisting of W1 and the neighboring benzene ring is naphthalene, tetrahydronaphthalene, or indan ring.

    摘要翻译： 使用具有下式（II）的化合物或其药理学上可接受的盐作为P2X4受体拮抗剂：其中R11和R12各自为氢，C1-8烷基等; R 13是氢，C 1-8烷基等; R14是氢，C1-8烷基，C1-8烷氧基，具有1-3个卤素的C1-8烷基，C1-8羟基烷基，卤素，羟基，硝基，氰基，氨基，C1-8烷基氨基，任选具有取代基的苯磺酰基氨基， 任选具有取代基的杂环基等; 由W1和相邻的苯环组成的稠环是萘，四氢萘或茚满环。

    P2X4 RECEPTOR ANTAGONIST
    9.
    发明申请
    P2X4 RECEPTOR ANTAGONIST 有权
    P2X4受体拮抗剂

    公开(公告)号：US20130184459A1

    公开(公告)日：2013-07-18

    申请号：US13811909

    申请日：2011-07-27

    申请人： Masatoshi Ushioda ,  Shogo Sakuma ,  Toshiyasu Imai ,  Kazuhide Inoue

    发明人： Masatoshi Ushioda ,  Shogo Sakuma ,  Toshiyasu Imai ,  Kazuhide Inoue

    IPC分类号： C07D239/70 ,  C07D403/10

    CPC分类号： C07D239/70 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D413/04 ,  C07D471/04

    摘要： A compound having the following formula (II) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: wherein each of R11 and R12 is hydrogen, C1-8 alkyl or the like; R13 is hydrogen, C1-8 alkyl or the like; R14 is C1-8 alkoxy, hydroxyl, cyano, a heterocyclic group optionally having a substituent or the like; and the condensed ring consisting of W1 and the neighboring benzene ring is naphthalene ring or the like.

    摘要翻译： 使用具有下式（II）的化合物或其药理学上可接受的盐作为P2X4受体拮抗剂：其中R11和R12各自为氢，C1-8烷基等; R 13是氢，C 1-8烷基等; R 14是C 1-8烷氧基，羟基，氰基，任选具有取代基的杂环基等; 并且由W1和相邻的苯环组成的稠环是萘环等。