公开(公告)号：US5536485A

公开(公告)日：1996-07-16

申请号：US288947

申请日：1994-08-11

申请人： Shoichi Kume ,  Haruo Yoshida ,  Yukiyoshi Yamada ,  Tadashi Fuyuki ,  Satoshi Akiyama ,  Yoshiaki Hamada ,  Eisuke Kuroda ,  Tadakatsu Nabeya ,  Yukio Sumita ,  Kenichi Kimura

发明人： Shoichi Kume ,  Haruo Yoshida ,  Yukiyoshi Yamada ,  Tadashi Fuyuki ,  Satoshi Akiyama ,  Yoshiaki Hamada ,  Eisuke Kuroda ,  Tadakatsu Nabeya ,  Yukio Sumita ,  Kenichi Kimura

IPC分类号： B01J3/06 ,  C04B35/5831 ,  C23C14/22 ,  C04B35/58

CPC分类号： C23C14/223 ,  B01J3/062 ,  C04B35/5831 ,  C23C14/22 ,  B01J2203/062 ,  B01J2203/0645 ,  B01J2203/0655 ,  B01J2203/066 ,  B01J2203/0685

摘要： A powder of diamond or high-pressure phase boron nitride core particles charged into a coating space as it is dispersed, and a precursor of a coat forming substance allowed to contact and/or impinge against the particles in the powder of core particles so that their surfaces are covered with the coat forming substance, thereby preparing coated diamond or high-pressure phase boron nitride particles which are subsequently sintered. The thusly produced diamond of high-pressure phase boron nitride sinter is composed of coated core particles of high performance that are superhard, uniform, dense and sintered firmly, and which have a controlled microstructure.

摘要翻译： 将金刚石或高压相氮化硼芯颗粒分散在涂层空间中的粉末，以及允许接触和/或撞击核心颗粒粉末中的颗粒的涂层形成物质的前体，使得它们 表面被涂层形成物质覆盖，从而制备随后烧结的涂层金刚石或高压相氮化硼颗粒。 这样制造的高压相氮化硼烧结体的金刚石由超硬，均匀，致密并且牢固地烧结并具有可控微观结构的高性能涂层芯颗粒组成。

公开(公告)号：US4716153A

公开(公告)日：1987-12-29

申请号：US900231

申请日：1986-08-25

申请人： Masataka Morishita ,  Masaru Ono ,  Yukio Sumita

发明人： Masataka Morishita ,  Masaru Ono ,  Yukio Sumita

IPC分类号： A61K47/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K47/02 ,  A61K47/12 ,  A61K47/16 ,  A61K47/18 ,  A61P31/04 ,  C07H17/08 ,  A61K31/19 ,  A61K35/00 ,  A61K37/44

CPC分类号： A61K31/70 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  C07H17/08

摘要： Stable oral preparations of 16-membered ring macrolide antibiotics such as SF-837, josamycin, 3"-propionyljosamycin, by incorporating stabilizers showing pH 3-10 in an aqueous medium, such as glycine, and dissolution accelerators showing pH 2.5-4 in an aqueous medium such as citric acid or tartaric acid. Coating such dissolution accelerators with a film-forming substance is useful to enhance the stability of the oral preparation of such antibiotics.

摘要翻译： 通过在水性介质（如甘氨酸）中加入显示出pH 3-10的稳定剂和显示pH 2.5-4的溶解促进剂，稳定地口服16-环环大环内酯类抗生素如SF-837，依沙霉素，3“ - 丙酰基焦马霉素 水性介质如柠檬酸或酒石酸。 用成膜物质涂覆这种溶解促进剂可用于增强这种抗生素口服制剂的稳定性。