公开(公告)号：US20100094000A1

公开(公告)日：2010-04-15

申请号：US12552701

申请日：2009-09-02

申请人： Shoji FUKUMOTO ,  Norio OHYABU ,  Taiichi OHRA ,  Takahiro SUGIMOTO ,  Tomoaki HASUI ,  Koji FUJI ,  Christopher S. SIEDEM ,  Cassandra GAUTHIER

发明人： Shoji FUKUMOTO ,  Norio OHYABU ,  Taiichi OHRA ,  Takahiro SUGIMOTO ,  Tomoaki HASUI ,  Koji FUJI ,  Christopher S. SIEDEM ,  Cassandra GAUTHIER

IPC分类号： C07D417/10

CPC分类号： C07D413/10 ,  C07D413/14 ,  C07D417/14

摘要： The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineralocorticoid receptor antagonistic action and is useful as an agent for the prophylaxis or treatment of a disease or condition mediated by the mineralocorticoid receptor activation.

摘要翻译： 本发明涉及其中每个符号如说明书中所定义的。 该化合物具有优异的盐皮质激素受体拮抗作用，并且可用作预防或治疗由盐皮质激素受体激活介导的疾病或病症的药剂。

公开(公告)号：US20120232095A1

公开(公告)日：2012-09-13

申请号：US13479955

申请日：2012-05-24

申请人： Tetsuya TSUKAMOTO ,  Takeshi WAKABAYASHI ,  Taiichi OHRA

发明人： Tetsuya TSUKAMOTO ,  Takeshi WAKABAYASHI ,  Taiichi OHRA

IPC分类号： A61K31/496 ,  A61P25/24 ,  A61P25/22 ,  A61P25/18 ,  A61P25/00 ,  A61P9/00 ,  A61P25/16 ,  A61P25/14 ,  A61P9/10 ,  A61P3/10 ,  A61P9/12 ,  C07D405/10 ,  A61P25/28

CPC分类号： C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/04 ,  C07D407/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D493/10

摘要： The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted homopiperazine ring; R1 and R2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; R3 and R4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; R5 to R7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, or a salt thereof.