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    Benzofuran derivatives
    1.
    发明授权
    Benzofuran derivatives 有权
    苯并呋喃衍生物

    公开(公告)号：US08288390B2

    公开(公告)日：2012-10-16

    申请号：US12659447

    申请日：2010-03-09

    申请人： Tetsuya Tsukamoto ,  Takeshi Wakabayashi ,  Taiichi Ohra

    发明人： Tetsuya Tsukamoto ,  Takeshi Wakabayashi ,  Taiichi Ohra

    IPC分类号： A61K31/496 ,  C07D405/02

    CPC分类号： C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/04 ,  C07D407/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D493/10

    摘要： The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted homopiperazine ring; R1 and R2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; R3 and R4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; R5 to R7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, or a salt thereof.

    摘要翻译： 本发明提供由下式（I）表示的化合物：其中：环A表示任选取代的哌嗪环，任选取代的吗啉环或任选取代的高哌嗪环; R1和R2彼此相同或不同，表示氢原子或任选取代的低级烷基; R3和R4彼此相同或不同，表示氢原子或卤代或非卤代低级烷基; R 5至R 7彼此相同或不同，并且表示氢原子，羟基，任选取代的低级烷基，任选取代的低级烯基，任选取代的低级烷氧基，任选取代的环烷基，任选取代的芳基，任选取代的芳族杂环， 任选取代的氨基或酰基; 并且表示单键或双键，或其盐。

    BENZOFURAN DERIVATIVES
    2.
    发明申请
    BENZOFURAN DERIVATIVES 审中-公开
    BENZOFURAN衍生物

    公开(公告)号：US20120232096A1

    公开(公告)日：2012-09-13

    申请号：US13479981

    申请日：2012-05-24

    申请人： Tetsuya Tsukamoto ,  Takeshi Wakabayashi ,  Taiichi Ohra

    发明人： Tetsuya Tsukamoto ,  Takeshi Wakabayashi ,  Taiichi Ohra

    IPC分类号： A61K31/496 ,  A61P25/24 ,  A61P25/22 ,  A61P25/18 ,  A61P25/00 ,  A61P9/00 ,  A61P25/16 ,  A61P25/14 ,  A61P9/10 ,  A61P3/10 ,  A61P9/12 ,  C07D405/10 ,  A61P25/28

    CPC分类号： C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/04 ,  C07D407/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D493/10

    摘要： The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted homopiperazine ring; R1 and R2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; R3 and R4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; R5 to R7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, or a salt thereof.

    摘要翻译： 本发明提供由下式（I）表示的化合物：其中：环A表示任选取代的哌嗪环，任选取代的吗啉环或任选取代的高哌嗪环; R1和R2彼此相同或不同，表示氢原子或任选取代的低级烷基; R3和R4彼此相同或不同，表示氢原子或卤代或非卤代低级烷基; R 5至R 7彼此相同或不同，并且表示氢原子，羟基，任选取代的低级烷基，任选取代的低级烯基，任选取代的低级烷氧基，任选取代的环烷基，任选取代的芳基，任选取代的芳族杂环， 任选取代的氨基或酰基; 并且表示单键或双键，或其盐。

    BENZOFURAN DERIVATIVES
    3.
    发明申请
    BENZOFURAN DERIVATIVES 有权
    BENZOFURAN衍生物

    公开(公告)号：US20120046277A1

    公开(公告)日：2012-02-23

    申请号：US13255366

    申请日：2010-03-09

    申请人： Tetsuya Tsukamoto ,  Takeshi Wakabayashi ,  Taiichi Ohra

    发明人： Tetsuya Tsukamoto ,  Takeshi Wakabayashi ,  Taiichi Ohra

    IPC分类号： A61K31/496 ,  C07D405/14 ,  C07D413/10 ,  A61P25/00 ,  C07D493/10 ,  A61K31/551 ,  A61K31/506 ,  A61P25/28 ,  C07D405/10 ,  A61K31/5377

    CPC分类号： C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/04 ,  C07D407/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D493/10

    摘要： The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted bromopiperazine ring; R1 and R2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; R3 and R4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; R3 to R7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloakyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, wherein R2 and R3 do not exist when carbon atoms respectively adjacent to R2: and R3 form a double bond, and there is no case where all of R1 to R7 are hydrogen atoms, and R1 and R2; may form a ring together with an adjacent carbon atom; or a salt thereof.

    摘要翻译： 本发明提供由下式（I）表示的化合物：其中：环A表示任选取代的哌嗪环，任选取代的吗啉环或任选取代的溴代哌嗪环; R1和R2彼此相同或不同，表示氢原子或任选取代的低级烷基; R3和R4彼此相同或不同，表示氢原子或卤代或非卤代低级烷基; R 3至R 7彼此相同或不同，并且表示氢原子，羟基，任选取代的低级烷基，任选取代的低级烯基，任选取代的低级烷氧基，任选取代的环烷基，任选取代的芳基，任选取代的芳族杂环， 任选取代的氨基或酰基; 并且表示单键或双键，其中当分别相邻于R2：和R3的碳原子形成双键时，R2和R3不存在，并且不存在所有R 1至R 7都是氢原子的情况，并且R 1和R 2 ; 可与邻近的碳原子一起形成环; 或其盐。

    Benzofuran derivatives
    5.
    发明申请
    Benzofuran derivatives 有权
    苯并呋喃衍生物

    公开(公告)号：US20100234357A1

    公开(公告)日：2010-09-16

    申请号：US12659447

    申请日：2010-03-09

    申请人： Tetsuya Tsukamoto ,  Takeshi Wakabayashi ,  Taiichi Ohra

    发明人： Tetsuya Tsukamoto ,  Takeshi Wakabayashi ,  Taiichi Ohra

    IPC分类号： A61K31/551 ,  C07D405/10 ,  A61K31/496 ,  C07D413/12 ,  A61K31/5377 ,  A61P25/28 ,  A61P25/00

    CPC分类号： C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/04 ,  C07D407/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D493/10

    摘要： The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted homopiperazine ring; R1 and R2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; R3 and R4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; R5 to R7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, or a salt thereof.

    摘要翻译： 本发明提供由下式（I）表示的化合物：其中：环A表示任选取代的哌嗪环，任选取代的吗啉环或任选取代的高哌嗪环; R1和R2彼此相同或不同，表示氢原子或任选取代的低级烷基; R3和R4彼此相同或不同，表示氢原子或卤代或非卤代低级烷基; R 5至R 7彼此相同或不同，并且表示氢原子，羟基，任选取代的低级烷基，任选取代的低级烯基，任选取代的低级烷氧基，任选取代的环烷基，任选取代的芳基，任选取代的芳族杂环， 任选取代的氨基或酰基; 并且表示单键或双键，或其盐。

    Benzofuran derivatives
    8.
    发明授权
    Benzofuran derivatives 有权
    苯并呋喃衍生物

    公开(公告)号：US08957069B2

    公开(公告)日：2015-02-17

    申请号：US13255366

    申请日：2010-03-09

    申请人： Tetsuya Tsukamoto ,  Takeshi Wakabayashi ,  Taiichi Ohra

    发明人： Tetsuya Tsukamoto ,  Takeshi Wakabayashi ,  Taiichi Ohra

    IPC分类号： A61K31/496 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/519 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D405/06 ,  C07D405/14 ,  C07D487/04 ,  C07D413/12 ,  C07D491/113 ,  C07D417/06 ,  C07D413/06 ,  C07D493/10 ,  C07D405/04 ,  C07D405/12 ,  C07D407/04 ,  C07D407/12 ,  C07D417/12 ,  A61K31/551 ,  C07D413/04

    CPC分类号： C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/04 ,  C07D407/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D493/10

    摘要： The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted bromopiperazine ring; R1 and R2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; R3 and R4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; R3 to R7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, wherein R2 and R3 do not exist when carbon atoms respectively adjacent to R2: and R3 form a double bond, and there is no case where all of R1 to R7 are hydrogen atoms, and R1 and R2; may form a ring together with an adjacent carbon atom; or a salt thereof.

    摘要翻译： 本发明提供由下式（I）表示的化合物：其中：环A表示任选取代的哌嗪环，任选取代的吗啉环或任选取代的溴代哌嗪环; R1和R2彼此相同或不同，表示氢原子或任选取代的低级烷基; R3和R4彼此相同或不同，表示氢原子或卤代或非卤代低级烷基; R 3至R 7彼此相同或不同，并且表示氢原子，羟基，任选取代的低级烷基，任选取代的低级烯基，任选取代的低级烷氧基，任选取代的环烷基，任选取代的芳基，任选取代的芳族杂环， 任选取代的氨基或酰基; 并且表示单键或双键，其中当分别相邻于R2：和R3的碳原子形成双键时，R2和R3不存在，并且不存在所有R 1至R 7都是氢原子的情况，并且R 1和R 2 ; 可与邻近的碳原子一起形成环; 或其盐。