专利检索 ap:("Shon Booker" OR "Tae-Seong Kim" OR "Hongyu Liao" OR "Longbin Liu" OR "Mark H. Norman" OR "Emily Anne Peterson" OR "Markian Stec" OR "Nuria A. Tamayo") AND inv:"Mark H. Norman" 第 1 页

1.

发明申请
Inhibitors of PI3 kinase 有权
标题翻译： PI3激酶抑制剂

公开(公告)号：US20090163489A1

公开(公告)日：2009-06-25

申请号：US12317166

申请日：2008-12-18

申请人： Shon Booker , Tae-Seong Kim , Hongyu Liao , Longbin Liu , Mark H. Norman , Emily Anne Peterson , Markian Stec , Nuria A. Tamayo

发明人： Shon Booker , Tae-Seong Kim , Hongyu Liao , Longbin Liu , Mark H. Norman , Emily Anne Peterson , Markian Stec , Nuria A. Tamayo

IPC分类号： A61K31/5025 , C07D487/04 , A61K31/5377 , A61P35/02 , A61P35/00 , C07D413/14

CPC分类号： C07D471/04 , C07D487/04

摘要： The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof, that inhibit phosphoinositide 3-kinase; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds.

摘要翻译： 本发明涉及抑制磷酸肌醇3-激酶的式I化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物。

2.

发明授权
Imidazopyridazine inhibitors of PI3 kinase for cancer treatment 有权
标题翻译：用于癌症治疗的PI3激酶的咪唑并哒嗪抑制剂

公开(公告)号：US07820665B2

公开(公告)日：2010-10-26

申请号：US12317166

申请日：2008-12-18

申请人： Shon Booker , Tae-Seong Kim , Hongyu Liao , Longbin Liu , Mark H. Norman , Emily Anne Peterson , Markian Stec , Nuria A. Tamayo

发明人： Shon Booker , Tae-Seong Kim , Hongyu Liao , Longbin Liu , Mark H. Norman , Emily Anne Peterson , Markian Stec , Nuria A. Tamayo

IPC分类号： A61K31/4188 , A61K31/5025 , C07D487/04

CPC分类号： C07D471/04 , C07D487/04

摘要： The present invention relates to imidazopyridazine compounds of Formula I, such as representative structure A, or a pharmaceutically acceptable salt thereof, that inhibit phosphoinositide 3-kinase; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds.

摘要翻译： 本发明涉及式I的咪唑并哒嗪化合物，例如抑制磷酸肌醇3-激酶的代表性结构A或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物。

3.

发明授权
Benzothiazole PI3 kinase modulators for cancer treatment 有权
标题翻译：用于癌症治疗的苯并噻唑PI3激酶调节剂

公开(公告)号：US07928140B2

公开(公告)日：2011-04-19

申请号：US12221416

申请日：2008-08-01

申请人： Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang

发明人： Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang

IPC分类号： A61K31/38

CPC分类号： C07D277/82 , C07D413/04 , C07D417/04 , C07D417/14 , C07D513/04

摘要： The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A1, A2, A3, A4, X, R1 and R2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.

摘要翻译： 本发明包括能够调节PI3激酶活性的新一类化合物，因此可用于治疗PI3激酶介导的疾病，包括黑素瘤，癌和其它癌症相关病症。所述化合物具有通式I，其中A1，A2，A3，A4，X，R1和R2各自在本文中定义。本发明还包括药物组合物，治疗PI3激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

4.

发明申请
PI3 kinase modulators and methods of use 有权
标题翻译： PI3激酶调节剂和使用方法

公开(公告)号：US20090054405A1

公开(公告)日：2009-02-26

申请号：US12221416

申请日：2008-08-01

申请人： Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang

发明人： Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang

IPC分类号： A61K31/55 , C07D401/14 , C07D401/10 , C07D413/14 , A61P35/00 , A61K31/435 , A61K31/5377 , A61K31/497

CPC分类号： C07D277/82 , C07D413/04 , C07D417/04 , C07D417/14 , C07D513/04

摘要： The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A1, A2, A3, A4, X, R1 and R2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.

摘要翻译： 本发明包括能够调节PI3激酶活性的新一类化合物，因此可用于治疗PI3激酶介导的疾病，包括黑素瘤，癌和其它癌症相关病症。所述化合物具有通式I，其中A1，A2，A3，A4，X，R1和R2各自在本文中定义。本发明还包括药物组合物，治疗PI3激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

5.

发明申请
INHIBITORS OF PI3 KINASE AND/OR MTOR 有权
标题翻译： PI3激酶和/或MTOR的抑制剂

公开(公告)号：US20100273764A1

公开(公告)日：2010-10-28

申请号：US12768602

申请日：2010-04-27

申请人： Kristin Andrews , Yunxin Y. Bo , Shon Booker , Victor J. Cee , Noel D'Angelo , Bradley J. Herberich , Fang-Tsao Hong , Claire L.M. Jackson , Brian A. Lanman , Hongyu Liao , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Seifu Tadesse , Nuria A. Tamayo , Bin Wu , Ryan Wurz , Kevin Yang

发明人： Kristin Andrews , Yunxin Y. Bo , Shon Booker , Victor J. Cee , Noel D'Angelo , Bradley J. Herberich , Fang-Tsao Hong , Claire L.M. Jackson , Brian A. Lanman , Hongyu Liao , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Seifu Tadesse , Nuria A. Tamayo , Bin Wu , Ryan Wurz , Kevin Yang

IPC分类号： A61K31/53 , C07D473/00 , A61K31/52 , C07D401/14 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D401/04 , C07D417/14 , C07D405/14 , A61K31/541 , C07D471/04 , C07D401/12 , C07D513/04 , A61P35/00 , A61P35/02

CPC分类号： C07D473/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14

摘要： The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.

摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物，其中变量如本文所定义。

6.

发明申请
FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE 有权
标题翻译：熔融杂环衍生物及其使用方法

公开(公告)号：US20120148531A1

公开(公告)日：2012-06-14

申请号：US13309488

申请日：2011-12-01

申请人： Brian K. ALBRECHT , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang

发明人： Brian K. ALBRECHT , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang

IPC分类号： A61K31/5025 , A61K31/5377 , A61K38/21 , A61P35/00 , A61P35/04 , C07D487/04 , A61K31/538

CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

7.

发明申请
FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE 审中-公开

公开(公告)号：US20120107275A1

公开(公告)日：2012-05-03

申请号：US13323692

申请日：2011-12-12

申请人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang

发明人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang

IPC分类号： A61K31/5025 , A61K31/5377 , C07D498/04 , A61K31/538 , A61K38/21 , A61P31/00 , A61P3/00 , A61P5/00 , A61P37/00 , C07D487/04 , A61P35/00

CPC分类号： C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

8.

发明申请
Fused heterocyclic derivatives and methods of use 有权

公开(公告)号：US20090318436A1

公开(公告)日：2009-12-24

申请号：US12287791

申请日：2008-10-14

申请人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michelle Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang

发明人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michelle Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang

IPC分类号： A61K31/5355 , C07D487/02 , A61K31/5025 , C07D413/14 , C07D471/02 , A61K31/437 , A61K31/53 , C07D498/02 , A61K31/4355 , A61P35/00

CPC分类号： C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

9.

发明申请
Fused heterocyclic derivatives and methods of use 有权
标题翻译：稠合杂环衍生物和使用方法

公开(公告)号：US20090124612A1

公开(公告)日：2009-05-14

申请号：US11879034

申请日：2007-07-13

申请人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang

发明人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang

IPC分类号： A61K31/5377 , C07D487/04 , C07D471/04 , A61P35/04 , A61K31/437 , A61K31/5025

CPC分类号： C07D471/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。