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公开(公告)号：US20100273764A1
公开(公告)日：2010-10-28
申请号：US12768602
申请日：2010-04-27
申请人： Kristin Andrews , Yunxin Y. Bo , Shon Booker , Victor J. Cee , Noel D'Angelo , Bradley J. Herberich , Fang-Tsao Hong , Claire L.M. Jackson , Brian A. Lanman , Hongyu Liao , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Seifu Tadesse , Nuria A. Tamayo , Bin Wu , Ryan Wurz , Kevin Yang
发明人： Kristin Andrews , Yunxin Y. Bo , Shon Booker , Victor J. Cee , Noel D'Angelo , Bradley J. Herberich , Fang-Tsao Hong , Claire L.M. Jackson , Brian A. Lanman , Hongyu Liao , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Seifu Tadesse , Nuria A. Tamayo , Bin Wu , Ryan Wurz , Kevin Yang
IPC分类号： A61K31/53 , C07D473/00 , A61K31/52 , C07D401/14 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D401/04 , C07D417/14 , C07D405/14 , A61K31/541 , C07D471/04 , C07D401/12 , C07D513/04 , A61P35/00 , A61P35/02
CPC分类号： C07D473/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物，其中变量如本文所定义。
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公开(公告)号：US20140031360A1
公开(公告)日：2014-01-30
申请号：US13991603
申请日：2011-12-07
申请人： Hui-Ling Wang , Kaustav Biswas , Victor J. Cee , Frank Chavez, JR. , Bradley J. Herberich , Claire L.M. Jackson , Brian A. Lanman , Matthew Lee , Thomas Nixey , Liping H. Pettus , Anthony B. Reed , Robert M. Rzasa , Shannon Rumfelt , Andrew Tasker , Bin Wu , Ryan Wurz
发明人： Hui-Ling Wang , Kaustav Biswas , Victor J. Cee , Frank Chavez, JR. , Bradley J. Herberich , Claire L.M. Jackson , Brian A. Lanman , Matthew Lee , Thomas Nixey , Liping H. Pettus , Anthony B. Reed , Robert M. Rzasa , Shannon Rumfelt , Andrew Tasker , Bin Wu , Ryan Wurz
IPC分类号： C07D401/14 , C07D405/14 , C07D403/14 , C07D417/14 , C07D471/04 , C07D405/04
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The invention relates to bicyclic compounds of formula (1′), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
摘要翻译： 本发明涉及式（1'）的双环化合物及其盐。 在一些实施方案中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。 在另外的实施方案中，本发明涉及包含本文公开的化合物的药物组合物及其在预防和治疗Pim激酶相关病症和疾病，优选癌症中的用途。
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公开(公告)号：US20140187553A1
公开(公告)日：2014-07-03
申请号：US14006285
申请日：2012-03-21
申请人： Hui-Ling Wang , Victor J. Cee , Bradley J. Herberich , Claire L.M. Jackson , Brian Alan Lanman , Thomas Nixey , Liping H. Pettus , Anthony B. Reed , Bin Wu , Ryan Wurz , Andrew Tasker
发明人： Hui-Ling Wang , Victor J. Cee , Bradley J. Herberich , Claire L.M. Jackson , Brian Alan Lanman , Thomas Nixey , Liping H. Pettus , Anthony B. Reed , Bin Wu , Ryan Wurz , Andrew Tasker
IPC分类号： C07D413/14 , C07D487/04 , C07D417/04 , C07D471/04 , C07D417/14
CPC分类号： C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The invention relates to bicyclic compounds of formulas I and Ia, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
摘要翻译： 本发明涉及式I和Ia的双环化合物及其盐。 在一些实施方案中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。 在另外的实施方案中，本发明涉及包含本文公开的化合物的药物组合物及其在预防和治疗Pim激酶相关病症和疾病，优选癌症中的用途。
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公开(公告)号：US09090593B2
公开(公告)日：2015-07-28
申请号：US13991603
申请日：2011-12-07
申请人： Hui-Ling Wang , Kaustav Biswas , Victor J. Cee , Frank Chavez, Jr. , Bradley J. Herberich , Claire L. M. Jackson , Brian A. Lanman , Matthew Lee , Thomas Nixey , Liping H. Pettus , Anthony B. Reed , Robert M. Rzasa , Shannon Rumfelt , Andrew Tasker , Bin Wu , Ryan Wurz
发明人： Hui-Ling Wang , Kaustav Biswas , Victor J. Cee , Frank Chavez, Jr. , Bradley J. Herberich , Claire L. M. Jackson , Brian A. Lanman , Matthew Lee , Thomas Nixey , Liping H. Pettus , Anthony B. Reed , Robert M. Rzasa , Shannon Rumfelt , Andrew Tasker , Bin Wu , Ryan Wurz
IPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D405/04
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The invention relates to bicyclic compounds of formula (1′), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
摘要翻译： 本发明涉及式（1'）的双环化合物及其盐。 在一些实施方案中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。 在另外的实施方案中，本发明涉及包含本文公开的化合物的药物组合物及其在预防和治疗Pim激酶相关病症和疾病，优选癌症中的用途。
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公开(公告)号：US09321756B2
公开(公告)日：2016-04-26
申请号：US14006285
申请日：2012-03-21
申请人： Hui-Ling Wang , Victor J. Cee , Bradley J. Herberich , Claire L. M. Jackson , Brian Alan Lanman , Thomas Nixey , Liping H. Pettus , Anthony B. Reed , Bin Wu , Ryan Wurz , Andrew Tasker
发明人： Hui-Ling Wang , Victor J. Cee , Bradley J. Herberich , Claire L. M. Jackson , Brian Alan Lanman , Thomas Nixey , Liping H. Pettus , Anthony B. Reed , Bin Wu , Ryan Wurz , Andrew Tasker
IPC分类号： C07D413/14 , C07D487/04 , C07D417/04 , C07D471/04 , C07D417/14 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The invention relates to bicyclic compounds of formulas I and Ia, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
摘要翻译： 本发明涉及式I和Ia的双环化合物及其盐。 在一些实施方案中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。 在另外的实施方案中，本发明涉及包含本文公开的化合物的药物组合物及其在预防和治疗Pim激酶相关病症和疾病，优选癌症中的用途。
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公开(公告)号：US07842685B2
公开(公告)日：2010-11-30
申请号：US12456687
申请日：2009-06-18
申请人： Victor J. Cee , Michael J. Frohn , Brian Alan Lanman , Susana C. Neira , Anthony B. Reed , Kelvin K. C. Sham
发明人： Victor J. Cee , Michael J. Frohn , Brian Alan Lanman , Susana C. Neira , Anthony B. Reed , Kelvin K. C. Sham
IPC分类号： A61K31/397 , A61K31/4365 , C07D513/04
CPC分类号： C07D513/04 , A61K9/2018 , A61K9/2059 , A61K9/48
摘要： The present invention relates to compounds of Formula (I): that are have activity as S1P receptor modulating agents, more specifically to specifically compounds that are S1P1 receptor agonists. The invention also related to the use of such compounds to treat diseases associated with inappropriate S1P1 receptor activity such as autoimmune diseases.
摘要翻译： 本发明涉及式（I）化合物：其具有作为S1P受体调节剂的活性，更具体地涉及作为S1P1受体激动剂的具体化合物。 本发明还涉及使用这些化合物来治疗与不适当的S1P1受体活性相关的疾病，例如自身免疫性疾病。
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公开(公告)号：US20100029611A1
公开(公告)日：2010-02-04
申请号：US12456687
申请日：2009-06-18
申请人： Victor J. Cee , Michael J. Frohn , Brian Alan Lanman , Susana C. Neira , Anthony B. Reed , Kelvin K.C. Sham
发明人： Victor J. Cee , Michael J. Frohn , Brian Alan Lanman , Susana C. Neira , Anthony B. Reed , Kelvin K.C. Sham
IPC分类号： A61K31/397 , C07D417/14 , A61K31/437 , C07D513/04 , A61P37/00
CPC分类号： C07D513/04 , A61K9/2018 , A61K9/2059 , A61K9/48
摘要： The present invention relates to compounds of Formula (I): that are have activity as S1P receptor modulating agents, more specifically to specifically compounds that are S1P1 receptor agonists. The invention also related to the use of such compounds to treat diseases associated with inappropriate S1P1 receptor activity such as autoimmune diseases.
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公开(公告)号：US20110212940A1
公开(公告)日：2011-09-01
申请号：US13034895
申请日：2011-02-25
申请人： Roland Burli , Victor J. Cee , Jennifer Golden , Brian Alan Lanman , Susana Neira , Ashis Saha , Nili Schutz , Xiang Yu , Dilara McCauley , Mercedes Lobera , Yael Marantz , Jian Lin , Srinivasa R. Cheruku , Pini Orbach , Anurag Sharadendu , Robert C. Penland , Kimberley Gannon , Sharon Shacham , Silvia Noiman , Oren Becker , Zhaoda Zhang
发明人： Roland Burli , Victor J. Cee , Jennifer Golden , Brian Alan Lanman , Susana Neira , Ashis Saha , Nili Schutz , Xiang Yu , Dilara McCauley , Mercedes Lobera , Yael Marantz , Jian Lin , Srinivasa R. Cheruku , Pini Orbach , Anurag Sharadendu , Robert C. Penland , Kimberley Gannon , Sharon Shacham , Silvia Noiman , Oren Becker , Zhaoda Zhang
IPC分类号： A61K31/397 , C07D405/10 , A61K31/4525 , C07D405/14 , A61K31/443 , C07D413/14 , A61K31/427 , C07D409/14 , A61K31/4725 , A61K31/4025 , C07D307/80 , A61K31/343 , A61K31/5377 , C07D413/10 , A61K31/41 , A61P35/00 , A61P37/06 , A61P29/00 , A61P3/10 , A61P25/00 , A61P17/06 , A61P35/02 , A61P11/00 , A61P11/06 , A61P17/02 , A61P9/00 , A61P9/10 , A61P13/12 , A61P1/16 , A61P7/06
CPC分类号： C07D307/79 , C07D307/80 , C07D307/81 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048
摘要： The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.
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公开(公告)号：US07919519B2
公开(公告)日：2011-04-05
申请号：US11726351
申请日：2007-03-21
申请人： Roland Burli , Victor J. Cee , Jennifer Golden , Brian Alan Lanman , Susana Neira , Ashis Saha , Nili Schutz , Xiang Yu , Dilara McCauley , Mercedes Lobera , Yael Marantz , Jian Lin , Srinivasa R. Cheruku , Pini Orbach , Anurag Sharadendu , Robert C. Penland , Kimberley Gannon , Sharon Shacham , Silvia Noiman , Oren Becker , Zhaoda Zhang
发明人： Roland Burli , Victor J. Cee , Jennifer Golden , Brian Alan Lanman , Susana Neira , Ashis Saha , Nili Schutz , Xiang Yu , Dilara McCauley , Mercedes Lobera , Yael Marantz , Jian Lin , Srinivasa R. Cheruku , Pini Orbach , Anurag Sharadendu , Robert C. Penland , Kimberley Gannon , Sharon Shacham , Silvia Noiman , Oren Becker , Zhaoda Zhang
IPC分类号： A61K31/404 , A61K31/381 , A61K31/343 , C07D209/12 , C07D333/56 , C07D307/80
CPC分类号： C07D307/79 , C07D307/80 , C07D307/81 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048
摘要： The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.
摘要翻译： 本发明涉及具有作为S1P受体调节剂的活性的通式（I）的化合物，以及这些化合物用于治疗与不适当的S1P受体活性有关的疾病的用途。 这些化合物可用作免疫调节剂，例如用于治疗或预防诸如自身免疫性疾病和相关免疫疾病（包括系统性红斑狼疮），炎症性肠病如克罗恩病和溃疡性结肠炎，I型糖尿病，葡萄膜炎，牛皮癣，重症肌无力，类风湿 关节炎，非肾小球性肾病，肝炎，白塞病，肾小球性肾炎，慢性血小板减少性紫癜，溶血性贫血，肝炎和韦格纳肉芽肿; 并处理其他条件。
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公开(公告)号：US20120129828A1
公开(公告)日：2012-05-24
申请号：US12995387
申请日：2009-06-18
申请人： Victor J. Cee , Jian Lin , Xiang Y. Yu , Zhaoda Zhang
发明人： Victor J. Cee , Jian Lin , Xiang Y. Yu , Zhaoda Zhang
IPC分类号： A61K31/397 , C07D409/14 , C07D409/10 , C07D405/14 , A61K31/4025 , A61K31/4525 , A61K31/4535 , A61K31/55 , A61K31/343 , A61K31/4178 , A61P25/00 , A61P19/02 , A61P1/00 , A61P11/06 , A61P3/10 , A61P11/00 , A61P31/00 , A61P35/04 , A61P35/00 , A61P35/02 , A61P21/04 , C07D405/10
CPC分类号： C07D513/04 , A61K9/2018 , A61K9/2059 , A61K9/48
摘要： The present invention relates to compounds of Formula (I) that are have activity as S1P1 receptor modulating agents, more specifically to specifically compounds that are S1P1 receptor agonists. The invention also related to the use of such compounds to treat diseases associated with inappropriate S1P1 receptor activity such as autoimmune diseases.
摘要翻译： 本发明涉及具有作为S1P1受体调节剂的活性的式（I）化合物，更具体地涉及具体为S1P1受体激动剂的化合物。 本发明还涉及使用这些化合物来治疗与不适当的S1P1受体活性相关的疾病，例如自身免疫性疾病。
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