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公开(公告)号：US09895318B2
公开(公告)日：2018-02-20
申请号：US15117062
申请日：2015-02-09
IPC分类号： A61K9/50 , A61K9/16 , A61K31/138 , A61K31/522
CPC分类号： A61K9/5073 , A61K9/1652 , A61K9/1676 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61K9/5047 , A61K9/5078 , A61K31/138 , A61K31/522
摘要： The invention refers to a pharmaceutical or nutraceutical composition, comprising a) a core, comprising a pharmaceutical or a nutraceutical active ingredient, b) an inner coating layer comprising one or more salts of alginic acid and c) an outer coating layer comprising one or more water-insoluble polymers or copolymers and one or more water-soluble polymers, selected from the group of water soluble celluloses, polyvinyl pyrrolidones or polyethylene glycols or any combinations thereof. wherein the ratio by weight of the amount of the one or more salts of alginic acid in the inner coating layer to the amount of the one or more water-insoluble polymers or copolymers in outer coating layer is from 0.6 to less than 2.5:1.
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2.发明申请公开(公告)号：US20160354319A1
公开(公告)日：2016-12-08
申请号：US15117062
申请日：2015-02-09
IPC分类号： A61K9/50 , A61K31/138 , A61K31/522
CPC分类号： A61K9/5073 , A61K9/1652 , A61K9/1676 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61K9/5047 , A61K9/5078 , A61K31/138 , A61K31/522
摘要： The invention refers to a pharmaceutical or nutraceutical composition, comprising a) a core, comprising a pharmaceutical or a nutraceutical active ingredient, b) an inner coating layer comprising one or more salts of alginic acid and c) an outer coating layer comprising one or more water-insoluble polymers or copolymers and one or more water-soluble polymers, selected from the group of water soluble celluloses, polyvinyl pyrrolidones or polyethylene glycols or any combinations thereof. wherein the ratio by weight of the amount of the one or more salts of alginic acid in the inner coating layer to the amount of the one or more water-insoluble polymers or copolymers in outer coating layer is from 0.6 to less than 2.5:1.
摘要翻译： 本发明涉及一种药物或营养药物组合物，其包含a）包含药物或营养药物活性成分的核心，b）包含一种或多种海藻酸盐的内包衣层和c）包含一种或多种 水不溶性聚合物或共聚物和一种或多种选自水溶性纤维素，聚乙烯吡咯烷酮或聚乙二醇或其任何组合的水溶性聚合物。 其中，所述内包衣层中的一种或多种海藻酸盐的量与外涂层中的一种或多种水不溶性聚合物或共聚物的量的重量比为0.6至小于2.5:1。
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3.发明申请GASTRIC RESISTANT PHARMACEUTICAL OR NUTRACEUTICAL COMPOSITION WITH RESISTANCE AGAINST THE INFLUENCE OF ETHANOL 审中-公开抗药性药物或营养成分对乙醇的影响具有抵抗力公开(公告)号：US20150209298A1
公开(公告)日：2015-07-30
申请号：US14416500
申请日：2012-10-18
IPC分类号： A61K9/50 , A61K31/138 , A61K31/4439 , A61K31/381 , A61K9/28 , A61K31/522
CPC分类号： A61K9/5073 , A61K9/2846 , A61K9/286 , A61K9/2886 , A61K9/2893 , A61K9/5026 , A61K9/5036 , A61K9/5047 , A61K9/5089 , A61K31/135 , A61K31/138 , A61K31/381 , A61K31/4439 , A61K31/522
摘要： A pharmaceutical or nutraceutical composition with a core, an inner layer, and an outercoating layer, wherein a pharmaceutical or a nutraceutical active ingredient is contained in the core, at least 30% by weight of a salt of alginic acid is contained in the inner layer, and at least 30% by weight of a polymer or copolymer with anionic side groups is contained in the outer coating layer.
摘要翻译： 具有核心，内层和外包衣层的药物或营养组合物，其中药物或营养药物活性成分包含在核心中，至少30重量％的海藻酸盐包含在内层中 ，并且在外涂层中含有至少30重量％的具有阴离子侧基的聚合物或共聚物。
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4.发明申请PHARMACEUTICAL OR NUTRACEUTICAL COMPOSITION WITH SUSTAINED RELEASE CHARACTERISTIC AND WITH RESISTANCE AGAINST THE INFLUENCE OF ETHANOL 审中-公开具有持续释放特性和抵抗ETHANOL影响的药物或营养组合物公开(公告)号：US20150190348A1
公开(公告)日：2015-07-09
申请号：US14416171
申请日：2012-10-18
IPC分类号： A61K9/28 , A61K9/16 , A61K9/20 , A61K31/522
CPC分类号： A61K9/2886 , A61K9/1623 , A61K9/1635 , A61K9/2095 , A61K9/2826 , A61K9/284 , A61K9/2846 , A61K9/286 , A61K9/2893 , A61K9/5026 , A61K9/5036 , A61K9/5073 , A61K31/522
摘要： A pharmaceutical or nutraceutical composition with a core, an inner coating layer, and an outercoating layer, wherein a pharmaceutical or a nutraceutical active ingredient is contained in the core, one or more salts of alginic acid is contained in the inner coating layer, and one or more water-insoluble polymers or copolymers is contained in the outer coating layer. In the composition, the ratio of the amount of the one or more salts of alginic acid in the inner coating layer is at least 2.5:1 by weight to the amount of the one or more water-insoluble polymers or copolymers in the outer coating layer.
摘要翻译： 具有芯，内涂层和外涂层的药物或营养组合物，其中药物或营养药物活性成分包含在核心中，一个或多个藻酸盐包含在内涂层中，一个 或更多的水不溶性聚合物或共聚物包含在外涂层中。 在组合物中，内涂层中的一种或多种藻酸的量的比例相对于外涂层中的一种或多种水不溶性聚合物或共聚物的量为至少2.5:1 。
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公开(公告)号：US20150250888A1
公开(公告)日：2015-09-10
申请号：US14430592
申请日：2012-11-27
CPC分类号： A61K47/32 , A61K9/10 , A61K9/2846
摘要： The invention discloses a process for preparing aqueous dispersions comprising the components (a) and (b) and optionally (c) or (d) or both, (a) a copolymer consisting of free-radical-polymerized C1- to C4-esters of acrylic or methacrylic acid and alkyl(meth)acrylate monomers with tertiary ammonium groups in the alkyl side groups, (b) 5 to 25% by weight, based on (a), of a C12- to C18-monocarboxylic acid or a C12- to C18-alcohol, (c) 0 to 10% by weight based on (a) of a dicarboxylic acid having 3 to 10 carbon atoms, (d) 0 to 20% by weight, based on (a), of an emulsifier having an HLB of at least 14 by dispersing the components in water where the water has a temperature of more than 40 and up to 85° C., where the solid content of the dispersion is from 5 to 40% by weight and where a clear colloidal dispersion is obtained in less than 30 min.
摘要翻译： 本发明公开了一种制备包含组分（a）和（b）和任选地（c）或（d）或两者的水分散体的方法，（a）由游离基聚合的C 1 -C 4酯 丙烯酸或甲基丙烯酸和烷基侧基具有叔铵基的（甲基）丙烯酸烷基酯单体，（b）基于（a）的5-25重量％的C12- C18-一元羧酸或C12- （c）0至10重量％，基于（a）具有3至10个碳原子的二羧酸，（d）0至20重量％（a），基于（a）的乳化剂，其具有 通过将组分分散在水中，其中水的温度高于40℃且高达85℃，其中固体含量为5至40重量％，并且其中透明胶体 在少于30分钟内获得分散体。
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