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公开(公告)号:US5959075A
公开(公告)日:1999-09-28
申请号:US905267
申请日:1997-08-01
申请人: Si Lok , Darrell C. Conklin , Robyn L Adams , Anna C. Jelmberg , Catherine E. Lofton-Day , Stephen R. Jaspers
发明人: Si Lok , Darrell C. Conklin , Robyn L Adams , Anna C. Jelmberg , Catherine E. Lofton-Day , Stephen R. Jaspers
IPC分类号: C12N15/09 , A61K31/00 , A61K38/00 , A61K38/28 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P15/00 , A61P15/08 , A61P15/16 , A61P15/18 , A61P43/00 , C07K14/62 , C07K14/625 , C07K14/64 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/16 , C12N15/17 , C12P21/02
摘要: The present invention provides testis-specific insulin homolog polypeptides and polynucleotides encoding the polypeptides, as well as related compositions and methods are disclosed. The polypeptides and polynucleotides may be used within methods for enhancing viability of cryopreserved sperm, for enhancing sperm motility, to enhance fertilization in methods of assisted reproduction, as contraceptives and other related uses.
摘要翻译: 本发明提供了睾丸特异性胰岛素同源物多肽和编码多肽的多核苷酸,以及相关的组合物和方法。 多肽和多核苷酸可以用于增强冷冻保存的精子的活力的方法,用于增强精子活力,增强辅助生殖方法中的受精作为避孕药具和其他相关用途。
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公开(公告)号:US06183991B2
公开(公告)日:2001-02-06
申请号:US09314051
申请日:1999-05-18
申请人: Si Lok , Darrell C. Conklin , Robyn L Adams , Anna C. Jelmberg , Catherine E. Lofton-Day , Stephen R. Jaspers
发明人: Si Lok , Darrell C. Conklin , Robyn L Adams , Anna C. Jelmberg , Catherine E. Lofton-Day , Stephen R. Jaspers
IPC分类号: C07H2104
摘要: The present invention provides testis-specific insulin homolog polypeptides and polynucleotides encoding the polypeptides, as well as related compositions and methods are disclosed. The polypeptides and polynucleotides may be used within methods for enhancing viability of cryopreserved sperm, for enhancing sperm motility, to enhance fertilization in methods of assisted reproduction, as contraceptives and other related uses.
摘要翻译: 本发明提供了睾丸特异性胰岛素同源物多肽和编码多肽的多核苷酸,以及相关的组合物和方法。 多肽和多核苷酸可以用于增强冷冻保存的精子的活力的方法,用于增强精子活力,增强辅助生殖方法中的受精作为避孕药具和其他相关用途。
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公开(公告)号:US5945511A
公开(公告)日:1999-08-31
申请号:US943087
申请日:1997-10-02
申请人: Si Lok , Choon J. Kho , Anna C. Jelmberg , Robyn L Adams , Theodore E. Whitmore , Theresa M. Farrah
发明人: Si Lok , Choon J. Kho , Anna C. Jelmberg , Robyn L Adams , Theodore E. Whitmore , Theresa M. Farrah
IPC分类号: G01N33/53 , C07K14/715 , C07K16/28 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91 , C07K1/00
CPC分类号: C07K14/715 , C07K2319/02 , Y10S930/12 , Y10S930/14
摘要: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in kidneys, pancreas, prostate, adrenal cortex and nervous tissue. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of these organs.
摘要翻译: 公开了新型受体多肽,编码多肽的多核苷酸,以及相关组合物和方法。 多肽包含在肾脏,胰腺,前列腺,肾上腺皮质和神经组织中表达的细胞表面受体的细胞外结构域。 多肽可用于检测促进这些器官的增殖和/或分化的配体的方法中。
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公开(公告)号:US5965704A
公开(公告)日:1999-10-12
申请号:US906713
申请日:1997-08-05
IPC分类号: G01N33/566 , C07K14/715 , C07K16/28 , C07K16/42 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08
CPC分类号: C07K14/715
摘要: Novel class II cytokine receptor polypeptides, polynucleotides encoding the polypeptides, an related compositions and methods are disclosed. Th polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in pancreas, small intestine, colon and thymus. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of these organs.
摘要翻译: 公开了新的II类细胞因子受体多肽,编码多肽的多核苷酸,相关组合物和方法。 Th多肽包含在胰腺,小肠,结肠和胸腺中表达的细胞表面受体的细胞外结构域。 多肽可用于检测促进这些器官的增殖和/或分化的配体的方法中。
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