公开(公告)号：US20200072755A1

公开(公告)日：2020-03-05

申请号：US16468532

申请日：2017-12-12

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Lloyd Schulman ,  Christopher Zimmerle ,  Julie Chaney

IPC: G01N21/78 ,  G01N21/84 ,  G01N33/52 ,  G01N21/25

Abstract: Methods of detecting compromise of at least one analyte reagent upon reaction with a test sample are disclosed. Also disclosed are reflectance spectroscopic diagnostic instruments that perform the method, and systems that contain same.

公开(公告)号：US20240299946A1

公开(公告)日：2024-09-12

申请号：US18552206

申请日：2022-03-28

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Lloyd Schulman

IPC: B01L3/00

CPC classification number: B01L3/5082 ,  B01L2200/148 ,  B01L2300/02 ,  B01L2300/042

Abstract: An analyzer control product provided with a sealed rack tube containing a preconfigured volume of analyzer control fluid is described. In particular, the rack tube is provided with a base portion; a top portion; and a sidewall extending from the base portion to the top portion, the sidewall having an inner peripheral surface and an outer peripheral surface, at least one of the inner peripheral surface and the outer peripheral surface in contact with the base portion to form a control fluid void. The analyzer control fluid is within the control fluid void. The analyzer control fluid has a preconfigured volume. A sealing member is attached to the top portion to seal the control void.

公开(公告)号：US11268907B2

公开(公告)日：2022-03-08

申请号：US16468532

申请日：2017-12-12

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Lloyd Schulman ,  Christopher Zimmerle ,  Julie Chaney

IPC: G01N21/78 ,  G01N21/25 ,  G01N21/84 ,  G01N33/52

Abstract: Methods of detecting compromise of at least one analyte reagent upon reaction with a test sample are disclosed. Also disclosed are reflectance spectroscopic diagnostic instruments that perform the method, and systems that contain same.

公开(公告)号：US20180306815A1

公开(公告)日：2018-10-25

申请号：US15524817

申请日：2015-11-17

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Krastyu Ugrinov ,  Lloyd Schulman ,  David Ledden ,  Janine Cox ,  Anne Novamo

IPC: G01N33/76 ,  G01N33/53 ,  G01N33/558 ,  C12M1/34 ,  G01N30/90 ,  G01N33/532

CPC classification number: G01N33/76 ,  C12M1/34 ,  G01N30/90 ,  G01N33/5306 ,  G01N33/532 ,  G01N33/558

Abstract: In one aspect, the inventive concepts disclosed herein are directed to a lateral flow assay comprising: one or more chromatographic substrates, a sample application site, a first capture site, and a second capture site. The first capture site comprising an anti-hCG capture antibody with broad affinity for a group of multiple hCG variants and the second capture site comprising an anti-hCG capture antibody that is specific to a first variant of hCG. Additional aspects of the invention disclose using the later flow assay to determine a ratio of the first variant of hCG to the group of multiple hCG variants.