公开(公告)号：US20220133376A1

公开(公告)日：2022-05-05

申请号：US17578289

申请日：2022-01-18

Applicant: Silver Bullet Therapeutics, Inc.

Inventor： Houdin DEHNAD ,  Bohdan Wolodymyr CHOPKO ,  Paul E. CHIRICO

IPC: A61B17/86 ,  A61B17/56 ,  A61M25/00 ,  A61L31/02 ,  A61L31/08 ,  A61L31/16

Abstract: Described herein are devices, systems and methods for treating disease and/or infection by the release of silver from an implant over an extended period of time. In particular, the devices described herein may be used to treat infections such as osteomyelitis by the controlled release of silver ions from multiple sites of an extended-use implant. This implant typically includes a plurality of arms that both anchor and help distribute the released ions within the tissue. Power may be applied to release the silver ions into the tissue.

公开(公告)号：US20190247538A1

公开(公告)日：2019-08-15

申请号：US16391195

申请日：2019-04-22

Applicant: Silver Bullet Therapeutics, Inc.

Inventor： Houdin DEHNAD ,  Paul E. CHIRICO ,  Bohdan Wolodymyr CHOPKO ,  John BARR ,  Robert Vincent McCORMICK ,  Julie LUCERO ,  Jason A. JEGGE

IPC: A61L27/18 ,  A61L31/16 ,  A01N25/34 ,  A61L31/08 ,  A61L27/54 ,  A61L29/10 ,  A61L29/16 ,  A61K33/24 ,  A61K33/30 ,  A61K33/38 ,  A61L31/14 ,  C08L67/04 ,  A61L27/30 ,  A61L27/58 ,  A61L31/06

CPC classification number: A61L27/18 ,  A01N25/34 ,  A61K33/24 ,  A61K33/30 ,  A61K33/38 ,  A61L27/306 ,  A61L27/54 ,  A61L27/58 ,  A61L29/106 ,  A61L29/16 ,  A61L31/06 ,  A61L31/088 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2420/06 ,  C08L67/04 ,  A01N59/16 ,  A01N59/20 ,  A61K2300/00

Abstract: Antimicrobial metal ion coatings and implants including them. In particular, described herein are coatings including an anodic metal (e.g., silver and/or zinc and/or copper) that is co-deposited with a cathodic metal (e.g., palladium, platinum, gold, molybdenum, titanium, iridium, osmium, rhodium, manganese, niobium or rhenium) on a substrate so that the anodic metal is galvanically released as antimicrobial ions when the apparatus is exposed to a bodily fluid. The anodic metal may be at least about 25 percent by volume of the coating, resulting in a network of anodic metal with less than 20% of the anodic metal in the coating fully encapsulated by cathodic metal. The implant may be configured as an implant such as a bone-screw or intramedullary rod-like body configured to receive a treatment cartridge having a coating as described.

公开(公告)号：US20210283303A1

公开(公告)日：2021-09-16

申请号：US17336246

申请日：2021-06-01

Applicant: Silver Bullet Therapeutics, Inc.

Inventor： Houdin DEHNAD ,  Paul E. CHIRICO ,  Bohdan Wolodymyr CHOPKO ,  John BARR ,  Robert Vincent McCORMICK ,  Julie LUCERO ,  Jason A. JEGGE

IPC: A61L27/18 ,  A61L31/14 ,  A61L27/30 ,  C08L67/04 ,  A61L31/08 ,  A61L31/06 ,  A61L27/58 ,  A61L27/54 ,  A61L31/16 ,  A01N25/34 ,  A61L29/10 ,  A61L29/16 ,  A61K33/24 ,  A61K33/30 ,  A61K33/38 ,  A61K33/242 ,  A61K33/243

Abstract: Antimicrobial metal ion coatings and implants including them. In particular, described herein are coatings including an anodic metal (e.g., silver and/or zinc and/or copper) that is co-deposited with a cathodic metal (e.g., palladium, platinum, gold, molybdenum, titanium, iridium, osmium, rhodium, manganese, niobium or rhenium) on a substrate so that the anodic metal is galvanically released as antimicrobial ions when the apparatus is exposed to a bodily fluid. The anodic metal may be at least about 25 percent by volume of the coating, resulting in a network of anodic metal with less than 20% of the anodic metal in the coating fully encapsulated by cathodic metal. The implant may be configured as an implant such as a bone-screw or intramedullary rod-like body configured to receive a treatment cartridge having a coating as described.