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![Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists](/abs-image/US/2013/01/08/US08349844B2/abs.jpg.150x150.jpg)
1.发明授权Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists 失效取代的吡唑并[1,5-A]嘧啶作为代谢型谷氨酸拮抗剂公开(公告)号：US08349844B2
公开(公告)日：2013-01-08
申请号：US13283640
申请日：2011-10-28
IPC分类号： C07D487/04 , A61K31/519 , C07D471/04 , A61P25/28 , A61P25/16 , A61K31/437
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.
摘要翻译： 本发明涉及式（I）化合物，其中A，E G，J，L，M，R 1，R 2和R 3如说明书和权利要求中所定义。 本发明还涉及含有这些化合物的药物组合物和用于制备化合物和组合物的方法。 化合物是代谢型谷氨酸受体拮抗剂，可用于治疗各种CNS疾病。
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![SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES AS METABOTROPIC GLUTAMATE ANTAGONISTS](/abs-image/US/2009/06/04/US20090143580A1/abs.jpg.150x150.jpg)
2.发明申请SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES AS METABOTROPIC GLUTAMATE ANTAGONISTS 失效取代的吡唑并[1,5-a]吡啶类作为代谢型谷氨酸拮抗剂公开(公告)号：US20090143580A1
公开(公告)日：2009-06-04
申请号：US12348962
申请日：2009-01-06
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.
摘要翻译： 本发明涉及式（I）化合物，其中A，E G，J，L，M，R 1，R 2和R 3如说明书和权利要求中所定义。 本发明还涉及含有这些化合物的药物组合物和用于制备化合物和组合物的方法。 化合物是代谢型谷氨酸受体拮抗剂，可用于治疗各种CNS疾病。
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公开(公告)号：US20070232583A1
公开(公告)日：2007-10-04
申请号：US11726575
申请日：2007-03-22
IPC分类号： A61K31/513 , A61K31/506 , C07D405/14 , C07D403/02 , C07D409/14
CPC分类号： C07D239/30 , C07D213/61 , C07D213/64 , C07D213/79 , C07D213/81 , C07D213/84 , C07D239/28 , C07D239/34 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F5/025
摘要： The present invention relates to compounds of formula (I), a process for the manufacture thereof, pharmaceutical compositions containing them, and their use for treating CNS disorders: wherein A, B, X, Y, R1, R2, R3 and R4 are as defined in the description and claims.
摘要翻译： 本发明涉及式（I）化合物，其制备方法，含有它们的药物组合物及其用于治疗CNS病症的用途：其中A，B，X，Y，R 1， R 2，R 3和R 4如在说明书和权利要求书中所定义。
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![SUBSTITUTED PYRAZOLO [1,5-A] PYRIMIDINES AS METABOTROPIC GLUTAMATE ANTAGONISTS](/abs-image/US/2012/02/16/US20120041002A1/abs.jpg.150x150.jpg)
4.发明申请SUBSTITUTED PYRAZOLO [1,5-A] PYRIMIDINES AS METABOTROPIC GLUTAMATE ANTAGONISTS 失效取代的吡唑并[1,5-A]吡啶类作为代谢型谷氨酸拮抗剂公开(公告)号：US20120041002A1
公开(公告)日：2012-02-16
申请号：US13283640
申请日：2011-10-28
IPC分类号： A61K31/519 , C07D471/04 , A61K31/437 , A61P25/00 , A61P25/28 , A61P3/08 , A61P25/16 , A61P25/08 , A61P25/06 , A61P25/30 , A61P25/18 , A61P25/36 , A61P25/22 , A61P25/14 , A61P25/24 , A61P35/00 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.
摘要翻译： 本发明涉及式（I）化合物，其中A，E G，J，L，M，R 1，R 2和R 3如说明书和权利要求中所定义。 本发明还涉及含有这些化合物的药物组合物和用于制备化合物和组合物的方法。 化合物是代谢型谷氨酸受体拮抗剂，可用于治疗各种CNS疾病。
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![Substituted pyrazolo [1,5-a] pyrimidines as metabotropic glutamate antagonists](/abs-image/US/2012/01/10/US08093263B2/abs.jpg.150x150.jpg)
5.发明授权Substituted pyrazolo [1,5-a] pyrimidines as metabotropic glutamate antagonists 失效取代的吡唑并[1,5-a]嘧啶作为代谢型谷氨酸拮抗剂公开(公告)号：US08093263B2
公开(公告)日：2012-01-10
申请号：US12348962
申请日：2009-01-06
IPC分类号： C07D471/04 , A61K31/519 , A61K31/437 , A61P25/28 , A61P25/16 , A61P25/18
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.
摘要翻译： 本发明涉及式（I）化合物，其中A，E G，J，L，M，R 1，R 2和R 3如说明书和权利要求中所定义。 本发明还涉及含有这些化合物的药物组合物和用于制备化合物和组合物的方法。 化合物是代谢型谷氨酸受体拮抗剂，可用于治疗各种CNS疾病。
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公开(公告)号：US20080300250A1
公开(公告)日：2008-12-04
申请号：US12189895
申请日：2008-08-12
申请人： Silvia Gatti McArthur , Erwin Goetschi , Wylie Solang Palmer , Juergen Wichmann , Thomas Johannes Woltering
发明人： Silvia Gatti McArthur , Erwin Goetschi , Wylie Solang Palmer , Juergen Wichmann , Thomas Johannes Woltering
IPC分类号： A61K31/5025 , C07D487/04 , A61K31/437 , A61K31/519
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of formula (I): wherein R1 to R3, A, M, L, E, G, and J are as defined in the description and claims. The invention also relates to a process for the manufacture of such compounds, pharmaceutical compositions containing them, and methods for treating CNS disorders.
摘要翻译： 本发明涉及式（I）化合物：其中R1至R3，A，M，L，E，G和J如说明书和权利要求中所定义。 本发明还涉及制备这些化合物的方法，含有它们的药物组合物和治疗CNS障碍的方法。
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公开(公告)号：US08183262B2
公开(公告)日：2012-05-22
申请号：US12551625
申请日：2009-09-01
IPC分类号： A61K31/44
CPC分类号： C07D239/30 , C07D213/61 , C07D213/64 , C07D213/79 , C07D213/81 , C07D213/84 , C07D239/28 , C07D239/34 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F5/025
摘要： The present invention relates to compounds of formula (I), a process for the manufacture thereof, pharmaceutical compositions containing them, and their use for treating CNS disorders: wherein A, B, X, Y, R1, R2, R3 and R4 are as defined in the description and claims.
摘要翻译： 本发明涉及式（I）化合物，其制备方法，含有它们的药物组合物及其用于治疗CNS障碍的用途：其中A，B，X，Y，R 1，R 2，R 3和R 4为 在说明书和权利要求中限定。
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公开(公告)号：US08063048B2
公开(公告)日：2011-11-22
申请号：US12748472
申请日：2010-03-29
申请人： Silvia Gatti McArthur , Erwin Goetschi , Wylie Solang Palmer , Juergen Wichmann , Thomas Johannes Woltering
发明人： Silvia Gatti McArthur , Erwin Goetschi , Wylie Solang Palmer , Juergen Wichmann , Thomas Johannes Woltering
IPC分类号： C07D487/04 , A61K31/5025 , A61P25/18 , A61P25/28 , A61K31/437
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of formula (I): wherein R1 to R3, A, M, L, E, G, and J are as defined in the description and claims. The invention also relates to a process for the manufacture of such compounds, pharmaceutical compositions containing them, and methods for treating CNS disorders.
摘要翻译： 本发明涉及式（I）化合物：其中R1至R3，A，M，L，E，G和J如说明书和权利要求中所定义。 本发明还涉及制备这些化合物的方法，含有它们的药物组合物和治疗CNS障碍的方法。
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公开(公告)号：US20100210642A1
公开(公告)日：2010-08-19
申请号：US12748472
申请日：2010-03-29
申请人： Silvia Gatti McArthur , Erwin Goetschi , Wylie Solang Palmer , Juergen Wichmann , Thomas Johannes Woltering
发明人： Silvia Gatti McArthur , Erwin Goetschi , Wylie Solang Palmer , Juergen Wichmann , Thomas Johannes Woltering
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/5025 , C07D413/14 , A61P25/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of formula (I): wherein R1 to R3, A, M, L, E, G, and J are as defined in the description and claims. The invention also relates to a process for the manufacture of such compounds, pharmaceutical compositions containing them, and methods for treating CNS disorders.
摘要翻译： 本发明涉及式（I）化合物：其中R1至R3，A，M，L，E，G和J如说明书和权利要求中所定义。 本发明还涉及制备这些化合物的方法，含有它们的药物组合物和治疗CNS障碍的方法。
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公开(公告)号：US20090318474A1
公开(公告)日：2009-12-24
申请号：US12551625
申请日：2009-09-01
IPC分类号： A61K31/506 , C07D409/02 , C07D401/00 , A61K31/4436 , A61P3/10
CPC分类号： C07D239/30 , C07D213/61 , C07D213/64 , C07D213/79 , C07D213/81 , C07D213/84 , C07D239/28 , C07D239/34 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F5/025
摘要： The present invention relates to compounds of formula (I), a process for the manufacture thereof, pharmaceutical compositions containing them, and their use for treating CNS disorders: wherein A, B, X, Y, R1, R2, R3 and R4 are as defined in the description and claims.
摘要翻译： 本发明涉及式（I）化合物，其制备方法，含有它们的药物组合物及其用于治疗CNS障碍的用途：其中A，B，X，Y，R 1，R 2，R 3和R 4为 在说明书和权利要求中限定。
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