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公开(公告)号：US09486005B2
公开(公告)日：2016-11-08
申请号：US13580471
申请日：2011-02-22
申请人： Smiti Vaid Gupta , Enrique Martinez, II , Fazlul H. Sarkar , Denis M. Callewaert , Andreea Geamanu , Kevin Michael Patrie , Tiffany Capri Thomas , Andrew A. Dahl
发明人： Smiti Vaid Gupta , Enrique Martinez, II , Fazlul H. Sarkar , Denis M. Callewaert , Andreea Geamanu , Kevin Michael Patrie , Tiffany Capri Thomas , Andrew A. Dahl
CPC分类号： A23L33/30 , A23L33/10 , A23L33/17 , A23V2002/00 , A61K9/0053 , A61K36/02 , A23V2200/3262 , A23V2250/202
摘要： A method of treating hypercholesterolemia in mammals, by administering an effective amount of a microbial fermentation product, and regulating genes involved in lipoprotein metabolism. A method of regulating cholesterol levels in a patient by administering an effective amount of a composition chosen from the group consisting of PAZ, specific components isolated from PAZ, chemically synthesized analogs of the components of PAZ, and regulating genes involved in lipoprotein metabolism. A method of treating high cholesterol levels in an individual by administering an effective amount of a microbial fermentation product, up-regulating the expression of at least one of the genes that encode ABCA1, ApoA1, and SRB1, and down-regulating the gene that encodes CETP. A method of preventing the onset of high cholesterol levels and/or a deleterious lipoprotein profile in an individual.
摘要翻译： 通过施用有效量的微生物发酵产物和调节涉及脂蛋白代谢的基因来治疗哺乳动物中的高胆固醇血症的方法。 通过施用有效量的选自PAZ，从PAZ分离的特异性成分，化学合成的PAZ组分的类似物和调节参与脂蛋白代谢的基因的组合来调节患者胆固醇水平的方法。 通过施用有效量的微生物发酵产物来治疗个体中高胆固醇水平的方法，上调编码ABCA1，ApoA1和SRB1的至少一个基因的表达，并下调编码的基因 CETP。 一种预防个体中高胆固醇水平和/或有害脂蛋白分布发生的方法。
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公开(公告)号：US20120328598A1
公开(公告)日：2012-12-27
申请号：US13580471
申请日：2011-02-22
申请人： Smiti Vaid Gupta , Enrique Martinez , Fazlul H. Sarkar , Denis M. Callewaert , Andreea Geamanu , Kevin Michael Patrie , Tiffany Capri Thomas , Andrew A. Dahl
发明人： Smiti Vaid Gupta , Enrique Martinez , Fazlul H. Sarkar , Denis M. Callewaert , Andreea Geamanu , Kevin Michael Patrie , Tiffany Capri Thomas , Andrew A. Dahl
CPC分类号： A23L33/30 , A23L33/10 , A23L33/17 , A23V2002/00 , A61K9/0053 , A61K36/02 , A23V2200/3262 , A23V2250/202
摘要： A method of treating hypercholesterolemia in mammals, by administering an effective amount of a microbial fermentation product, and regulating genes involved in lipoprotein metabolism. A method of regulating cholesterol levels in a patient by administering an effective amount of a composition chosen from the group consisting of PAZ, specific components isolated from PAZ, chemically synthesized analogues of the components of PAZ, and regulating genes involved in lipoprotein metabolism. A method of treating high cholesterol levels in an individual by administering an effective amount of a microbial fermentation product, up-regulating the expression of at least one of the genes that encode ABCA1, ApoA1, and SRB1, and down-regulating the gene that encodes CETP. A method of preventing the onset of high cholesterol levels and/or a deleterious lipoprotein profile in an individual.
摘要翻译： 通过施用有效量的微生物发酵产物和调节涉及脂蛋白代谢的基因来治疗哺乳动物中的高胆固醇血症的方法。 通过施用有效量的选自PAZ，从PAZ分离的特异性成分，化学合成的PAZ组分的类似物和调节参与脂蛋白代谢的基因的组合物来调节患者胆固醇水平的方法。 通过施用有效量的微生物发酵产物来治疗个体中高胆固醇水平的方法，上调编码ABCA1，ApoA1和SRB1的至少一个基因的表达，并下调编码的基因 CETP。 一种预防个体中高胆固醇水平和/或有害脂蛋白分布发生的方法。
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公开(公告)号：US20170135391A1
公开(公告)日：2017-05-18
申请号：US15330830
申请日：2016-11-07
CPC分类号： A23L33/30 , A23L33/10 , A23L33/17 , A23V2002/00 , A61K9/0053 , A61K36/02 , A23V2200/3262 , A23V2250/202
摘要： A method of treating hypercholesterolemia in mammals, by administering an effective amount of a microbial fermentation product, and regulating genes involved in lipoprotein metabolism. A method of regulating cholesterol levels in a patient by administering an effective amount of a composition chosen from the group consisting of PAZ, specific components isolated from PAZ, chemically synthesized analogues of the components of PAZ, and regulating genes involved in lipoprotein metabolism. A method of treating high cholesterol levels in an individual by administering an effective amount of a microbial fermentation product, up-regulating the expression of at least one of the genes that encode ABCA1, ApoA1, and SRB1, and down-regulating the gene that encodes CETP. A method of preventing the onset of high cholesterol levels and/or a deleterious lipoprotein profile in an individual.
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