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公开(公告)号：US09486005B2
公开(公告)日：2016-11-08
申请号：US13580471
申请日：2011-02-22
申请人： Smiti Vaid Gupta , Enrique Martinez, II , Fazlul H. Sarkar , Denis M. Callewaert , Andreea Geamanu , Kevin Michael Patrie , Tiffany Capri Thomas , Andrew A. Dahl
发明人： Smiti Vaid Gupta , Enrique Martinez, II , Fazlul H. Sarkar , Denis M. Callewaert , Andreea Geamanu , Kevin Michael Patrie , Tiffany Capri Thomas , Andrew A. Dahl
CPC分类号： A23L33/30 , A23L33/10 , A23L33/17 , A23V2002/00 , A61K9/0053 , A61K36/02 , A23V2200/3262 , A23V2250/202
摘要： A method of treating hypercholesterolemia in mammals, by administering an effective amount of a microbial fermentation product, and regulating genes involved in lipoprotein metabolism. A method of regulating cholesterol levels in a patient by administering an effective amount of a composition chosen from the group consisting of PAZ, specific components isolated from PAZ, chemically synthesized analogs of the components of PAZ, and regulating genes involved in lipoprotein metabolism. A method of treating high cholesterol levels in an individual by administering an effective amount of a microbial fermentation product, up-regulating the expression of at least one of the genes that encode ABCA1, ApoA1, and SRB1, and down-regulating the gene that encodes CETP. A method of preventing the onset of high cholesterol levels and/or a deleterious lipoprotein profile in an individual.
摘要翻译： 通过施用有效量的微生物发酵产物和调节涉及脂蛋白代谢的基因来治疗哺乳动物中的高胆固醇血症的方法。 通过施用有效量的选自PAZ，从PAZ分离的特异性成分，化学合成的PAZ组分的类似物和调节参与脂蛋白代谢的基因的组合来调节患者胆固醇水平的方法。 通过施用有效量的微生物发酵产物来治疗个体中高胆固醇水平的方法，上调编码ABCA1，ApoA1和SRB1的至少一个基因的表达，并下调编码的基因 CETP。 一种预防个体中高胆固醇水平和/或有害脂蛋白分布发生的方法。
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公开(公告)号：US20170135391A1
公开(公告)日：2017-05-18
申请号：US15330830
申请日：2016-11-07
CPC分类号： A23L33/30 , A23L33/10 , A23L33/17 , A23V2002/00 , A61K9/0053 , A61K36/02 , A23V2200/3262 , A23V2250/202
摘要： A method of treating hypercholesterolemia in mammals, by administering an effective amount of a microbial fermentation product, and regulating genes involved in lipoprotein metabolism. A method of regulating cholesterol levels in a patient by administering an effective amount of a composition chosen from the group consisting of PAZ, specific components isolated from PAZ, chemically synthesized analogues of the components of PAZ, and regulating genes involved in lipoprotein metabolism. A method of treating high cholesterol levels in an individual by administering an effective amount of a microbial fermentation product, up-regulating the expression of at least one of the genes that encode ABCA1, ApoA1, and SRB1, and down-regulating the gene that encodes CETP. A method of preventing the onset of high cholesterol levels and/or a deleterious lipoprotein profile in an individual.
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公开(公告)号：US20120328598A1
公开(公告)日：2012-12-27
申请号：US13580471
申请日：2011-02-22
申请人： Smiti Vaid Gupta , Enrique Martinez , Fazlul H. Sarkar , Denis M. Callewaert , Andreea Geamanu , Kevin Michael Patrie , Tiffany Capri Thomas , Andrew A. Dahl
发明人： Smiti Vaid Gupta , Enrique Martinez , Fazlul H. Sarkar , Denis M. Callewaert , Andreea Geamanu , Kevin Michael Patrie , Tiffany Capri Thomas , Andrew A. Dahl
CPC分类号： A23L33/30 , A23L33/10 , A23L33/17 , A23V2002/00 , A61K9/0053 , A61K36/02 , A23V2200/3262 , A23V2250/202
摘要： A method of treating hypercholesterolemia in mammals, by administering an effective amount of a microbial fermentation product, and regulating genes involved in lipoprotein metabolism. A method of regulating cholesterol levels in a patient by administering an effective amount of a composition chosen from the group consisting of PAZ, specific components isolated from PAZ, chemically synthesized analogues of the components of PAZ, and regulating genes involved in lipoprotein metabolism. A method of treating high cholesterol levels in an individual by administering an effective amount of a microbial fermentation product, up-regulating the expression of at least one of the genes that encode ABCA1, ApoA1, and SRB1, and down-regulating the gene that encodes CETP. A method of preventing the onset of high cholesterol levels and/or a deleterious lipoprotein profile in an individual.
摘要翻译： 通过施用有效量的微生物发酵产物和调节涉及脂蛋白代谢的基因来治疗哺乳动物中的高胆固醇血症的方法。 通过施用有效量的选自PAZ，从PAZ分离的特异性成分，化学合成的PAZ组分的类似物和调节参与脂蛋白代谢的基因的组合物来调节患者胆固醇水平的方法。 通过施用有效量的微生物发酵产物来治疗个体中高胆固醇水平的方法，上调编码ABCA1，ApoA1和SRB1的至少一个基因的表达，并下调编码的基因 CETP。 一种预防个体中高胆固醇水平和/或有害脂蛋白分布发生的方法。
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公开(公告)号：US5518885A
公开(公告)日：1996-05-21
申请号：US229515
申请日：1994-04-19
申请人： Raziuddin , Fazlul H. Sarkar
发明人： Raziuddin , Fazlul H. Sarkar
CPC分类号： C07K14/4705
摘要： The present invention provides a purified and isolated DNA-binding protein, HPBF, which specifically binds to the promoter region of the Her-2/neu (ERBB2/c-erbB-2) gene sequence, the presence of which provides an early indication of transition to a cancerous state has been found. The present invention also provides bioassays for screening substances for the ability to inhibit HPBF activity, the ability to inhibit the mitogenic activity of HPBF and the ability to inhibit HPBF production. The present invention further provides methods of inhibiting the biological activity mediated by HPBF comprising preventing the HPBF from binding to the promoter region of the ERBB2 gene sequence.
摘要翻译： 本发明提供纯化和分离的DNA结合蛋白HPBF，其特异性结合Her-2 / neu（ERBB2 / c-erbB-2）基因序列的启动子区，其存在提供了 已经发现过渡到癌症状态。 本发明还提供了用于筛选物质以抑制HPBF活性的能力的生物测定，抑制HPBF的促有丝分裂活性的能力和抑制HPBF产生的能力。 本发明还提供抑制由HPBF介导的生物活性的方法，包括防止HPBF与ERBB2基因序列的启动子区结合。
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公开(公告)号：US20090239943A1
公开(公告)日：2009-09-24
申请号：US12382520
申请日：2009-03-18
申请人： Fazlul H. Sarkar
发明人： Fazlul H. Sarkar
IPC分类号： A61K31/352 , A61P29/00
CPC分类号： A61K31/05 , A61K31/12 , A61K45/06 , A61K2300/00
摘要： A composition for inhibiting the activity of NF kappa B or for inhibiting tissue damage inflammation due to disease including a combination of green tea polyphenols; resveratrol; soy isoflavones, and curcumin. Also disclosed is a method of inhibiting the activity at the NF kappa B or inflammation using the composition.
摘要翻译： 用于抑制NFκB活性或抑制由于疾病引起的组织损伤的组合物的组合物，包括绿茶多酚的组合; 白藜芦醇 大豆异黄酮和姜黄素。 还公开了使用该组合物抑制NFκB或炎症活性的方法。
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公开(公告)号：US20140303109A1
公开(公告)日：2014-10-09
申请号：US13637358
申请日：2011-03-25
申请人： Fazlul H. Sarkar , Subhash Padhye
发明人： Fazlul H. Sarkar , Subhash Padhye
IPC分类号： C07F1/08 , A61K31/12 , A61K31/7068 , A61K31/282 , A61K31/353 , A61K31/415 , A61K31/513 , C07C49/255 , A61K31/30
CPC分类号： C07F1/08 , A61K31/12 , A61K31/20 , A61K31/282 , A61K31/30 , A61K31/352 , A61K31/353 , A61K31/415 , A61K31/505 , A61K31/513 , A61K31/7068 , C07C49/255 , A61K2300/00
摘要： Water-soluble fluorinated analogs of natural curcumin, and particularly difluoro Knoevenagel condensates and Schiff bases, along with their corresponding copper (H) complexes have improved bioavailablity over curcumin. The fluorine-substituted analogs of curcumin are useful as chemopreventive and/or therapeutic agents against cancers and/or against the development of drug-resistant cancer. A preferred compound is (IE,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene{4(3,4 difluorobenzaldehyde)}-3,5-dione.
摘要翻译： 天然姜黄素，特别是二氟Knoevenagel缩合物和席夫碱的水溶性氟化类似物及其相应的铜（H）配合物具有改善的姜黄素生物利用度。 姜黄素的氟取代类似物可用作抗癌和/或抵抗耐药性癌症发展的化学预防和/或治疗剂。 优选的化合物是（IE，6E）-1,7-双（4-羟基-3-甲氧基苯基）七-1,6-二烯{4（3,4-二氟苯甲醛）} -3,5-二酮。
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公开(公告)号：US07049410B2
公开(公告)日：2006-05-23
申请号：US10302868
申请日：2002-11-25
IPC分类号： C07K16/00
CPC分类号： C07K14/71 , C07K16/2863
摘要： This invention relates to ERRP (EGF-Receptor Related Protein) specific antibodies that could be used 1) to study the functional properties of ERRP and; 2) as a diagnostic and prognostic tool for malignancies. Preferably, the antibody reacts with a segment of ERRP containing 15 amino acids (SEQ ID NO: 4) that possesses the most antigenic property.
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