公开(公告)号：US20090202556A1

公开(公告)日：2009-08-13

申请号：US12049581

申请日：2008-03-17

申请人： So OHTA ,  Hiroshi ANDO ,  Masayo SUZUKI ,  Shinobu KAWAMOTO ,  Mariko NAKANO ,  Kazuyasu Nakamura

发明人： So OHTA ,  Hiroshi ANDO ,  Masayo SUZUKI ,  Shinobu KAWAMOTO ,  Mariko NAKANO ,  Kazuyasu Nakamura

IPC分类号： A61K39/395 ,  C07K16/00 ,  C12N5/12 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12P21/08 ,  C12Q1/68 ,  A61P35/00

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as “CLDN4”) gene or a polypeptide encoded by a Claudin-3 (hereinafter referred to as “CLDN3”) gene, or a method for using the same. Accordingly, the present invention provides a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of an extracellular region of CLDN4 and binds to the extracellular region; a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of both of extracellular regions of CLDN3 and CLDN4 and binds to the extracellular regions; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtained by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by CLDN4 gene and/or CLDN3 gene using the antibody or the antibody fragment.

摘要翻译： 本发明的目的是提供一种单克隆抗体，其可用作与由紧密连接蛋白-4（以下称为“CLDN4”）基因编码的多肽相关的疾病的诊断剂或治疗剂，或者由 紧密连接蛋白-3（以下称为“CLDN3”）基因或其使用方法。 因此，本发明提供特异性识别CLDN4的细胞外区域的三维结构并结合细胞外区域的单克隆抗体或其抗体片段; 单克隆抗体或其抗体片段，其特异性识别CLDN3和CLDN4的细胞外区域的三维结构并结合细胞外区域; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过转化载体获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用抗体或抗体片段的与CLDN4基因和/或CLDN3基因编码的多肽有关的疾病的诊断剂或治疗剂。

公开(公告)号：US20130135646A1

公开(公告)日：2013-05-30

申请号：US13678671

申请日：2012-11-16

申请人： Mami AKIYAMA ,  Yasuhiro SAGAWA ,  Masaharu FURUYA ,  Manabu IZUMIKAWA ,  Mikio ISHIBASHI ,  Yoshio HATTORI ,  So OHTA ,  Ryo TAKENAKA ,  Hiroaki MURAKAMI

发明人： Mami AKIYAMA ,  Yasuhiro SAGAWA ,  Masaharu FURUYA ,  Manabu IZUMIKAWA ,  Mikio ISHIBASHI ,  Yoshio HATTORI ,  So OHTA ,  Ryo TAKENAKA ,  Hiroaki MURAKAMI

IPC分类号： G06F3/12

CPC分类号： G06F3/12 ,  G03G15/502 ,  G03G15/70

摘要： An operator guidance system includes a detection unit, a control unit, and an operation indicator. The detection unit is disposed in an image forming apparatus to output a combination of detection signals, and includes one or more media sensors, and one or more opening sensors. The one or more media sensors are disposed along a media conveyance path to output a media detection signal. The one or more opening sensors are disposed adjacent to an openable structure to output an opening detection signal. The control unit is connected to the detection unit to determine guidance to be provided to an operator based on the combination of detection signals, and includes a memory and a controller. The operation indicator is connected to the control unit to indicate the identified operation to the operator.

摘要翻译： 操作者引导系统包括检测单元，控制单元和操作指示器。 检测单元设置在图像形成装置中以输出检测信号的组合，并且包括一个或多个介质传感器和一个或多个打开传感器。 一个或多个介质传感器沿着介质传送路径布置以输出介质检测信号。 一个或多个打开传感器被布置成与可打开的结构相邻以输出打开检测信号。 控制单元连接到检测单元，以基于检测信号的组合确定要提供给操作者的指导，并且包括存储器和控制器。 操作指示器连接到控制单元以向操作者指示所识别的操作。