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104 条记录 (耗时 0.047 秒)

    ANTI-CLAUDIN-4 ANTIBODY
    1.
    发明申请
    ANTI-CLAUDIN-4 ANTIBODY 失效
    抗组蛋白-4抗体

    公开(公告)号：US20090202556A1

    公开(公告)日：2009-08-13

    申请号：US12049581

    申请日：2008-03-17

    申请人： So OHTA ,  Hiroshi ANDO ,  Masayo SUZUKI ,  Shinobu KAWAMOTO ,  Mariko NAKANO ,  Kazuyasu Nakamura

    发明人： So OHTA ,  Hiroshi ANDO ,  Masayo SUZUKI ,  Shinobu KAWAMOTO ,  Mariko NAKANO ,  Kazuyasu Nakamura

    IPC分类号： A61K39/395 ,  C07K16/00 ,  C12N5/12 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12P21/08 ,  C12Q1/68 ,  A61P35/00

    CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

    摘要： An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as “CLDN4”) gene or a polypeptide encoded by a Claudin-3 (hereinafter referred to as “CLDN3”) gene, or a method for using the same. Accordingly, the present invention provides a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of an extracellular region of CLDN4 and binds to the extracellular region; a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of both of extracellular regions of CLDN3 and CLDN4 and binds to the extracellular regions; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtained by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by CLDN4 gene and/or CLDN3 gene using the antibody or the antibody fragment.

    摘要翻译： 本发明的目的是提供一种单克隆抗体，其可用作与由紧密连接蛋白-4（以下称为“CLDN4”）基因编码的多肽相关的疾病的诊断剂或治疗剂，或者由 紧密连接蛋白-3（以下称为“CLDN3”）基因或其使用方法。 因此，本发明提供特异性识别CLDN4的细胞外区域的三维结构并结合细胞外区域的单克隆抗体或其抗体片段; 单克隆抗体或其抗体片段，其特异性识别CLDN3和CLDN4的细胞外区域的三维结构并结合细胞外区域; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过转化载体获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用抗体或抗体片段的与CLDN4基因和/或CLDN3基因编码的多肽有关的疾病的诊断剂或治疗剂。

    Anti-claudin-4 antibody
    2.
    发明授权
    Anti-claudin-4 antibody 失效
    抗紧密连蛋白-4抗体

    公开(公告)号：US08076458B2

    公开(公告)日：2011-12-13

    申请号：US12049581

    申请日：2008-03-17

    申请人： So Ohta ,  Hiroshi Ando ,  Masayo Suzuki ,  Shinobu Kawamoto ,  Mariko Nakano ,  Kazuyasu Nakamura

    发明人： So Ohta ,  Hiroshi Ando ,  Masayo Suzuki ,  Shinobu Kawamoto ,  Mariko Nakano ,  Kazuyasu Nakamura

    IPC分类号： C07K16/00 ,  G01N33/53

    CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

    摘要： An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as “CLDN4”) gene or a polypeptide encoded by a Claudin-3 (hereinafter referred to as “CLDN3”) gene, or a method for using the same. Accordingly, the present invention provides a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of an extracellular region of CLDN4 and binds to the extracellular region; a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of both of extracellular regions of CLDN3 and CLDN4 and binds to the extracellular regions; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtained by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by CLDN4 gene and/or CLDN3 gene using the antibody or the antibody fragment.

    摘要翻译： 本发明的目的是提供一种单克隆抗体，其可用作与由紧密连接蛋白-4（以下称为“CLDN4”）基因编码的多肽相关的疾病的诊断剂或治疗剂，或者由 紧密连接蛋白-3（以下称为“CLDN3”）基因或其使用方法。 因此，本发明提供特异性识别CLDN4的细胞外区域的三维结构并结合细胞外区域的单克隆抗体或其抗体片段; 单克隆抗体或其抗体片段，其特异性识别CLDN3和CLDN4的细胞外区域的三维结构并结合细胞外区域; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过转化载体获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用抗体或抗体片段的与CLDN4基因和/或CLDN3基因编码的多肽有关的疾病的诊断剂或治疗剂。

    Method of enhancing of binding activity of antibody composition to Fcγ receptor IIIa
    9.
    发明授权
    Method of enhancing of binding activity of antibody composition to Fcγ receptor IIIa 有权
    增强抗体组合物与Fcγ受体IIIa的结合活性的方法

    公开(公告)号：US08313913B2

    公开(公告)日：2012-11-20

    申请号：US12550160

    申请日：2009-08-28

    申请人： Kazuyasu Nakamura ,  Kenya Shitara

    发明人： Kazuyasu Nakamura ,  Kenya Shitara

    IPC分类号： G01N31/00 ,  C07K16/00

    CPC分类号： C12P21/02 ,  A61K39/395 ,  C07K16/22 ,  C07K16/283 ,  C07K16/2866 ,  C07K16/3084 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2319/30

    摘要： A method for enhancing a binding activity of an antibody composition to Fcγ receptor IIIa, which comprises modifying a complex N-glycoside-linked sugar chain which is bound to the Fc region of an antibody molecule; a method for enhancing an antibody-dependent cell-mediated cytotoxic activity of an antibody composition; a process for producing an antibody composition having an enhanced binding activity to Fcγ receptor IIIa; a method for detecting the ratio of a sugar chain in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chain among total complex N-glycoside-linked sugar chains bound to the Fc region in an antibody composition; an Fc fusion protein composition produced by using a cell resistant to a lectin which recognizes a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in a complex N-glycoside-linked sugar chain; and a process for producing the same.

    摘要翻译： 一种增强抗体组合物与Fcγ受体IIIa的结合活性的方法，其包括修饰与抗体分子的Fc区结合的复合N-糖苷连接的糖链; 用于增强抗体依赖性细胞介导的抗体组合物的细胞毒活性的方法; 制备对Fcγ受体IIIa具有增强的结合活性的抗体组合物的方法; 在抗体组合物中与Fc区结合的总复合N-糖苷连接的糖链中，检测糖链与还原末端中的岩藻糖不与N-乙酰葡糖胺结合的糖链的比例的方法; 通过使用对凝集素有抗性的细胞产生的Fc融合蛋白质组合物，所述细胞通过复合N-糖苷中的α-键识别糖链的1-位与还原末端的N-乙酰葡糖胺的6-位结合的糖链 链糖链 及其制造方法。