公开(公告)号：US20250064555A1

公开(公告)日：2025-02-27

申请号：US18938820

申请日：2024-11-06

Applicant: Solventum Intellectual Properties Company

Inventor： Randilynn B. Christensen ,  Kenton D. Budd ,  Afshin Falsafi ,  Mahmut Aksit ,  Jana Ninkovic ,  Jie J. Liu ,  Mark B. Agre ,  Masayuki Nakamura ,  Jason W. Bjork ,  Bradley D. Craig ,  Richard P. Rusin ,  Paul J. Homnick ,  Joel D. Oxman ,  Yizhong Wang ,  Paul R. Klaiber

IPC: A61C5/64 ,  A61C5/68 ,  A61K6/17 ,  A61K6/61 ,  A61K6/62 ,  A61K6/71 ,  A61K6/818 ,  A61K6/851 ,  A61K6/853 ,  A61K6/876 ,  A61K6/887 ,  A61K6/889 ,  C08K9/10 ,  C08L33/10

Abstract: A hardenable (e.g. dental) compositions is described comprising an encapsulated material. The encapsulated material comprises a basic core material and an inorganic shell material having certain viscosity criteria. Also described are dispensing devices and kits are described comprising a hardenable (e.g. dental) composition comprising a liquid material and an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core. The dispensing devices and kits can facilitate the methods of applying the hardenable composition. The hardenable or hardened (e.g. cured) composition can provide various technical effects such as a delayed release of a basic core material, a delayed increase in basicity, promoting remineralization of a tooth or bone structure, and increasing the average alkaline phosphatase (ALP) activity of pulp cells. In some embodiments, the composition is a dental (e.g. sealant) composition for application to a tooth structure.

公开(公告)号：US12023393B2

公开(公告)日：2024-07-02

申请号：US18281229

申请日：2022-02-03

Applicant: Solventum Intellectual Properties Company

Inventor： Stephen B. Roscoe ,  Paul J. Homnick ,  Ahmed S. Abuelyaman

IPC: A61K6/891 ,  C07D493/10

CPC classification number: A61K6/891 ,  C07D493/10

Abstract: A polymerizable compound is represented by the formula (I). Each R1 independently represents a monovalent group having from 3 to 12 carbon atoms that comprises at least one of an epoxy group, an acryl group, or a methacryl group. Each R2 independently represents H, F, Cl, Br, C1-C12 alkyl, C2-C3 carbonylalkyl, or C2-C5 carboalkoxy. Each R3 independently represents H, F, Cl, Br, C1-C12 alkyl, C2-C3 carbonylalkyl, or C2-C5 carboalkoxy. Each n is independently 0, 1, 2, 3, or 4. Curable compositions including the polymerizable compound are also disclosed.

公开(公告)号：US20240423755A1

公开(公告)日：2024-12-26

申请号：US18820899

申请日：2024-08-30

Applicant: Solventum Intellectual Properties Company

Inventor： Randilynn B. Christensen ,  Kenton D. Budd ,  Afshin Falsafi ,  Mahmut Aksit ,  Jana Ninkovic ,  Jie J. Liu ,  Mark B. Agre ,  Masayuki Nakamura ,  Jason W. Bjork ,  Bradley D. Craig ,  Richard P. Rusin ,  Paul J. Homnick ,  Joel D. Oxman ,  Yizhong Wang ,  Paul R. Klaiber ,  Bill H. Dodge

IPC: A61C5/64 ,  A61K6/61 ,  A61K6/79 ,  A61K6/887

Abstract: A method of applying a two-part dental sealant is described comprising providing a syringe device comprising a cartridge including first and second chamber. The first chamber contains a first part of a dental sealant comprising a (meth)acrylate resin and an oxidizing curing agent. The second chamber contains a second part of a dental sealant comprising a (meth)acrylate resin and a reducing curing agent that reacts with the oxidizing curing agent of the first chamber. The first and/or second part of the dental sealant further comprise a single component or multiple components that neutralize acid and promote remineralization. The syringe device comprises a dispensing nozzle comprising a static mixer and an outlet at one end of the cartridge and a plunger at the opposing end of the cartridge. Also described is a kit for storing and applying the dental sealant is described.

公开(公告)号：US12161523B2

公开(公告)日：2024-12-10

申请号：US15734357

申请日：2019-06-05

Applicant: Solventum Intellectual Properties Company

Inventor： Randilynn B. Christensen ,  Kenton D. Budd ,  Afshin Falsafi ,  Mahmut Aksit ,  Jana Ninkovic ,  Jie J. Liu ,  Mark B. Agre ,  Masayuki Nakamura ,  Jason W. Bjork ,  Bradley D. Craig ,  Richard P. Rusin ,  Paul J. Homnick ,  Joel D. Oxman ,  Yizhong Wang ,  Paul R. Klaiber

IPC: A61C5/64 ,  A61C5/68 ,  A61K6/17 ,  A61K6/61 ,  A61K6/62 ,  A61K6/71 ,  A61K6/818 ,  A61K6/851 ,  A61K6/853 ,  A61K6/876 ,  A61K6/887 ,  C08K9/10 ,  A61K6/889 ,  C08L33/10

Abstract: A hardenable (e.g. dental) compositions is described comprising an encapsulated material. The encapsulated material comprises a basic core material and an inorganic shell material having certain viscosity criteria. Also described are dispensing devices and kits are described comprising a hardenable (e.g. dental) composition comprising a liquid material and an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core. The dispensing devices and kits can facilitate the methods of applying the hardenable composition. The hardenable or hardened (e.g. cured) composition can provide various technical effects such as a delayed release of a basic core material, a delayed increase in basicity, promoting remineralization of a tooth or bone structure, and increasing the average alkaline phosphatase (ALP) activity of pulp cells. In some embodiments, the composition is a dental (e.g. sealant) composition for application to a tooth structure.

公开(公告)号：US12059319B2

公开(公告)日：2024-08-13

申请号：US17597599

申请日：2020-07-28

Applicant: Solventum Intellectual Properties Company

Inventor： Andreas J. Boehm ,  Marc Peuker ,  Paul J. Homnick ,  Bruce R. Broyles

IPC: A61C5/62 ,  A61C5/50 ,  A61C5/64 ,  A61M3/00 ,  A61M3/02

CPC classification number: A61C5/50 ,  A61C5/62 ,  A61C5/64 ,  A61M3/005 ,  A61M3/0201 ,  A61M3/0262

Abstract: A syringe assembly being assembled from a syringe for dispensing a dental or medical substance, and a protective cover. The protective cover has a geometrically determined, non-foldable tubular protective shaft. The syringe has a cartridge having an outlet for the substance. Further, the cartridge and the protective cover are assembled with the cartridge being received within the protective shaft. The syringe further comprises a dispensing tip that is connected to the outlet for dispensing the substance from the dispensing tip. A first seal is provided between the dispensing tip and the outlet, and a second seal is provided between the dispensing tip and the protective shaft.

公开(公告)号：US11992539B2

公开(公告)日：2024-05-28

申请号：US18032655

申请日：2021-11-03

Applicant: Solventum Intellectual Properties Company

Inventor： Paul J. Homnick ,  Ahmed S. Abuelyaman

IPC: A61K6/887 ,  A61K6/16 ,  A61K6/17 ,  A61K6/71

CPC classification number: A61K6/887 ,  A61K6/16 ,  A61K6/17 ,  A61K6/71

Abstract: A curable dental composition includes a compound having structural formula (A) where X is an amine-, oxygen-, or sulfur-containing linkage; Y is an amine-, oxygen-, or sulfur-containing linkage; n is 1-15; m is 1-5; p is 1-5, with the proviso that when p is greater than 1, m is 1; each R1 is, independently, an alkyl or aryl group having 2 to 20 carbon atoms that is linear, branched, cyclic, or some combination thereof, and optionally includes one or more heteroatoms or unsaturated bonds; and each R2 is, independently, a hydrogen atom or CH3 The composition also includes filler. The filler is present in an amount of at least 25 wt.-%, based on the total weight of the curable dental composition.