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1.发明申请Method of Improving Anticancer Effect of Pulsatillae Radix and a Composition Prepared by the Method 审中-公开提高白头翁药物抗肿瘤效果的方法及其制备方法公开(公告)号：US20080268072A1
公开(公告)日：2008-10-30
申请号：US11658891
申请日：2005-07-29
申请人： Song-Bae Kim , Byeong Jun An , Hye Young Kim , Jong Seok Kim , Jong Uk Kim , Seong Cheol Bang , Jee Hyun Lee
发明人： Song-Bae Kim , Byeong Jun An , Hye Young Kim , Jong Seok Kim , Jong Uk Kim , Seong Cheol Bang , Jee Hyun Lee
CPC分类号： A61K36/71
摘要： The present invention relates to a composition enriched with 3-0-[O-α-L-rhamnopyranosyl-(1→2)-[0-β-D-glucopyranosyl-(1-→4)]-α-L-arabinopyranosyl]hederagenin (Code No. SB 365) of which antitumor activity is very strong by enzyme-reacting and extracting Pulsatillac radix.
摘要翻译： 本发明涉及富含3-0- [O-α-L-鼠李糖吡喃糖基 - （1-> 2） - [0-β-D-吡喃葡萄糖基 - （1→4）]-α-L - 阿拉伯吡喃糖基] hederagenin（编号SB365），其抗肿瘤活性通过酶反应和提取白头翁药物而非常强烈。
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2.发明申请COMPOSITION FOR PREVENTING AND TREATING CARDIOVASCULAR DISEASES, CONTAINING PYRAZOLE DERIVATIVE 审中-公开用于预防和治疗含有吡唑衍生物的心血管疾病的组合物公开(公告)号：US20140088152A1
公开(公告)日：2014-03-27
申请号：US14002103
申请日：2012-02-27
申请人： Yun Soo Bae , Kee In Lee , Jee Hyun Lee , Han Joong Jo , Jinoh Kim
发明人： Yun Soo Bae , Kee In Lee , Jee Hyun Lee , Han Joong Jo , Jinoh Kim
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , A61K31/4155 , A61K31/506
摘要： The present invention provides a composition comprising a pyrazole derivative compound and a pharmaceutically acceptable salt thereof. The composition is remarkably effective for preventing and treating cardiovascular diseases.
摘要翻译： 本发明提供包含吡唑衍生物化合物及其药学上可接受的盐的组合物。 该组合物对于预防和治疗心血管疾病是非常有效的。
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3.发明申请CHEMICAL INHIBITOR OF P53-SNAIL BINDING AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER DISEASE CONTAINING SAME AS ITS ACTIVE INGREDIENT 审中-公开P53-SNAIL结合的化学抑制剂和药物组合物用于治疗包含其中的癌症疾病作为其主动成分公开(公告)号：US20120015960A1
公开(公告)日：2012-01-19
申请号：US13130159
申请日：2009-11-23
申请人： Bum Joon Park , Nam Chul Ha , Sun Hye Lee , Gyu Yong Song , Jee Hyun Lee
发明人： Bum Joon Park , Nam Chul Ha , Sun Hye Lee , Gyu Yong Song , Jee Hyun Lee
IPC分类号： A61K31/495 , C07D211/16 , C07C313/24 , C07C323/22 , C07C323/62 , C07C323/41 , G01N33/566 , C12N5/09 , A61K31/451 , A61K31/165 , A61K31/10 , A61K31/192 , A61K31/216 , A61P35/00 , C07D295/192
CPC分类号： G01N33/5748 , A61K31/10 , A61K31/122 , C07C317/44 , C07C323/52 , C07C2602/10
摘要： Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective treatment or prevention of K-Ras mutant cancer, such as, pancreatic cancer, lung cancer, cholangioma, and colon cancer, of which diagnosis or treatment is not easy.
摘要翻译： 提供了用于抑制Snail-p53结合的化合物和用于癌症的治疗剂，包括该化合物作为有效成分。 Snail-p53结合抑制剂诱导K-Ras突变细胞系中p53的表达，从而能够有效治疗或预防K-Ras突变型癌症，如胰腺癌，肺癌，胆管癌和结肠癌，其中诊断或 治疗并不容易。
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4.发明申请PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTING AND TREATING OSTEOPOROSIS CONTAINING SAME 审中-公开吡唑衍生物及其制备方法，以及用于预防和治疗含有其的卵泡组织的组合物公开(公告)号：US20140128418A1
公开(公告)日：2014-05-08
申请号：US14002094
申请日：2012-02-27
申请人： Yun Soo Bae , Kee In Lee , Jee Hyun Lee , Soo Young Lee , Sun Choi
发明人： Yun Soo Bae , Kee In Lee , Jee Hyun Lee , Soo Young Lee , Sun Choi
IPC分类号： C07D403/04 , C07D401/04
CPC分类号： C07D403/04 , A61K31/454 , C07D239/42 , C07D401/04
摘要： The present invention provides a pyrazole derivative compound and a pharmaceutically acceptable salt thereof. The compound of the invention is remarkably effective for preventing and treating osteoporosis.
摘要翻译： 本发明提供吡唑衍生物化合物及其药学上可接受的盐。 本发明化合物对于预防和治疗骨质疏松症是非常有效的。
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5.发明授权Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same 有权吡唑衍生物，其制备方法和用于预防和治疗含有其的骨质疏松症的组合物公开(公告)号：US08637674B2
公开(公告)日：2014-01-28
申请号：US13393800
申请日：2010-09-02
申请人： Yun Soo Bae , Jee Hyun Lee , Mi Sun Seo , Soo Young Lee , Sun Choi , Kee In Lee , Hye Rin Bin
发明人： Yun Soo Bae , Jee Hyun Lee , Mi Sun Seo , Soo Young Lee , Sun Choi , Kee In Lee , Hye Rin Bin
IPC分类号： C07D213/00 , A61K31/44
CPC分类号： C07D401/04
摘要： The present invention provides pyrazole derivative compounds and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of preventing and treating osteoporosis.
摘要翻译： 本发明提供吡唑衍生物化合物及其药学上可接受的盐。 本发明的化合物具有优异的预防和治疗骨质疏松症的效果。
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公开(公告)号：US08604210B2
公开(公告)日：2013-12-10
申请号：US13393794
申请日：2010-09-02
申请人： Yun Soo Bae , Jee Hyun Lee , Mi Sun Seo , Soo Young Lee , Sun Choi , Kee In Lee , Hye Rin Bin , Do Min Lee
发明人： Yun Soo Bae , Jee Hyun Lee , Mi Sun Seo , Soo Young Lee , Sun Choi , Kee In Lee , Hye Rin Bin , Do Min Lee
IPC分类号： C07D401/00 , A61K31/695
CPC分类号： C07F7/0812 , C07D401/04 , C07D403/04 , C07D405/14 , C07F5/025
摘要： The present invention provides pyrazole derivative compounds and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of preventing and treating osteoporosis.
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公开(公告)号：US20120232117A1
公开(公告)日：2012-09-13
申请号：US13393800
申请日：2010-09-02
申请人： Yun Soo Bae , Jee Hyun Lee , Mi Sun Seo , Soo Young Lee , Sun Choi , Kee In Lee , Hye Rin Bin
发明人： Yun Soo Bae , Jee Hyun Lee , Mi Sun Seo , Soo Young Lee , Sun Choi , Kee In Lee , Hye Rin Bin
IPC分类号： A61K31/4439 , A61P19/10 , C07D401/04
CPC分类号： C07D401/04
摘要： The present invention provides pyrazole derivative compounds and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of preventing and treating osteoporosis.
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8.发明申请PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME 有权吡唑衍生物，其制备方法和组合物，用于预防和治疗含有其的卵磷脂公开(公告)号：US20120220550A1
公开(公告)日：2012-08-30
申请号：US13393794
申请日：2010-09-02
申请人： Yun Soo Bae , Jee Hyun Lee , Mi Sun Seo , Soo Young Lee , Sun Choi , Kee In Lee , Hye Rin Bin , Do Min Lee
发明人： Yun Soo Bae , Jee Hyun Lee , Mi Sun Seo , Soo Young Lee , Sun Choi , Kee In Lee , Hye Rin Bin , Do Min Lee
IPC分类号： A61K31/695 , A61K31/4439 , C07D403/04 , A61K31/506 , A61P39/06 , C07F5/02 , A61K31/69 , C07D405/14 , A61P19/10 , C07D401/04 , C07F7/18
CPC分类号： C07F7/0812 , C07D401/04 , C07D403/04 , C07D405/14 , C07F5/025
摘要： The present invention provides pyrazole derivative compounds and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of preventing and treating osteoporosis.
摘要翻译： 本发明提供吡唑衍生物化合物及其药学上可接受的盐。 本发明的化合物具有优异的预防和治疗骨质疏松症的效果。
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