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公开(公告)号：US20150132794A1
公开(公告)日：2015-05-14
申请号：US14407839
申请日：2013-06-21
申请人： Sony DADC Austria AG
CPC分类号： G01N33/5005 , C12M23/12 , C12M25/00 , C12M41/36 , C12M41/46 , G01N33/5308
摘要： A method of manufacturing a batch of sample containers optimized for culturing particular animal cells or binding particular proteins under particular growth conditions. When a customer requires a batch of sample containers, an appropriate surface is first selected by a testing process. A test container is provided which has a surface subdivided into a plurality of test areas, for example in a two-dimensional square array. Each test area has a pre-defined combination of surface properties including a micro- or nano-structure and these properties are varied from test area to test area. The animal cells or protein of interest are then tested under the particular conditions to be used. The test area that provides the ‘best’ conditions is then selected. The manufacture of a production batch of containers is then carried out, wherein the test areas in the production batch all copy the ‘best’ surface structure selected in the test.
摘要翻译： 制备一批样品容器的方法，其优化用于培养特定动物细胞或在特定生长条件下结合特定蛋白质。 当客户需要一批样品容器时，首先通过测试过程选择合适的表面。 提供了一种测试容器，其具有被分为多个测试区域的表面，例如在二维正方形阵列中。 每个测试区域具有预定义的表面性质的组合，包括微结构或纳米结构，并且这些性质从测试区域到测试区域不同。 然后在要使用的特定条件下测试感兴趣的动物细胞或蛋白质。 然后选择提供“最佳”条件的测试区域。 然后进行生产批次的容器的制造，其中生产批次中的测试区域都复制了在测试中选择的“最佳”表面结构。
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公开(公告)号：US09136099B2
公开(公告)日：2015-09-15
申请号：US13834827
申请日：2013-03-15
申请人： Sony DADC Austria AG
CPC分类号： H01J49/164 , B29C45/00 , B29C45/372 , C30B7/005 , C30B7/02 , C30B29/54 , H01J49/0418 , Y10T428/24355
摘要： A structured substrate is described which is suitable for forming and hosting a crystal array, as well as associated methods for making and using such a structured substrate. The structured substrate is made by injection molding and has on one side a combination of macro- and micro-structured features. Each macro-structured feature comprises an edge that forms a perimeter around an enclosed area containing a large number of the micro-structured features. When a droplet of a solution containing molecules of interest and a solvent is deposited onto one of the enclosed areas such that it extends somewhat beyond the perimeter, the droplet slowly dries and shrinks through evaporation of the solvent, during which the edge acts to seed crystallization of the molecules, and the micro-structured features act to direct crystal growth from the seed into the enclosed area. The crystal thus forms over the whole of the enclosed area in a shape that conforms to the perimeter. Crystals of a desired size and shape can therefore be formed.
摘要翻译： 描述了适用于形成和承载晶体阵列的结构化衬底，以及用于制造和使用这种结构化衬底的相关方法。 结构化基底通过注射成型制成，并且在一侧具有宏观结构和微结构特征的组合。 每个宏结构特征包括围绕包含大量微结构特征的封闭区域形成周边的边缘。 当包含感兴趣的分子和溶剂的溶液的液滴沉积到一个封闭区域上，使得其稍微延伸超出周边时，液滴通过溶剂的蒸发而缓慢地干燥和收缩，在此期间边缘起作用以晶种结晶 的分子，并且微结构特征用于将晶种生长从种子引导到封闭区域。 因此，晶体在整个封闭区域中形成为符合周边的形状。 因此可以形成所需尺寸和形状的晶体。
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