-
公开(公告)号:US06255100B1
公开(公告)日:2001-07-03
申请号:US09392282
申请日:1999-09-09
申请人: Soo Young Ko , Hans Kobel , Brigitte Besemer-Rosenwirth , Dieter Seebach , RenéP. Traber , Roland Wenger , Pietro Bollinger
发明人: Soo Young Ko , Hans Kobel , Brigitte Besemer-Rosenwirth , Dieter Seebach , RenéP. Traber , Roland Wenger , Pietro Bollinger
IPC分类号: C12N114
CPC分类号: A61K38/13 , C07K7/645 , Y10S435/911 , Y10S930/27
摘要: It has been found that nonimmunosuppressive, cyclophilin-binding cyclosporins are useful in the treatment and prevention of AIDS and AIDS-related disorders. Such cyclosporins include novel Ciclosporin derivatives modified at the 4- and/or 5-positions.
摘要翻译: 已经发现,非免疫抑制性亲环蛋白结合环孢菌素可用于治疗和预防艾滋病和AIDS相关疾病。 这种环孢菌素包括在4-和/或5-位修饰的新的环孢菌素衍生物。
-
公开(公告)号:US5981479A
公开(公告)日:1999-11-09
申请号:US84709
申请日:1998-05-26
申请人: Soo Young Ko , Hans Kobel , Brigitte Besemer-Rosenwirth , Dieter Seebach , Rene P. Traber , Roland Wenger , Pietro Bollinger
发明人: Soo Young Ko , Hans Kobel , Brigitte Besemer-Rosenwirth , Dieter Seebach , Rene P. Traber , Roland Wenger , Pietro Bollinger
IPC分类号: A61K38/00 , A61K38/13 , A61P29/00 , A61P31/12 , A61P31/18 , A61P33/10 , A61P37/06 , C07K7/64 , C07K14/195 , C07K14/41 , C12N1/14 , C12P21/02 , C12P21/04 , C12R1/645
CPC分类号: A61K38/13 , C07K7/645 , Y10S435/911 , Y10S930/27
摘要: It has been found that nonimmunosuppressive, cyclophilin-binding cyclosporins are useful in the treatment and prevention of AIDS and AIDS-related disorders. Such cyclosporins include novel Ciclosporin derivatives modified at the 4- and/or 5-positions.
摘要翻译: 已经发现,非免疫抑制性亲环蛋白结合环孢菌素可用于治疗和预防艾滋病和AIDS相关疾病。 这种环孢菌素包括在4-和/或5-位修饰的新的环孢菌素衍生物。
-
公开(公告)号:US5767069A
公开(公告)日:1998-06-16
申请号:US427312
申请日:1995-04-24
申请人: Soo Young Ko , Hans Kobel , Brigitte Besemer-Rosenwirth , Dieter Seebach , Rene P. Traber , Roland Wenger , Pietro Bollinger
发明人: Soo Young Ko , Hans Kobel , Brigitte Besemer-Rosenwirth , Dieter Seebach , Rene P. Traber , Roland Wenger , Pietro Bollinger
IPC分类号: A61K38/00 , A61K38/13 , A61P29/00 , A61P31/12 , A61P31/18 , A61P33/10 , A61P37/06 , C07K7/64 , C07K14/195 , C07K14/41 , C12N1/14 , C12P21/02 , C12P21/04 , C12R1/645
CPC分类号: A61K38/13 , C07K7/645 , Y10S435/911 , Y10S930/27
摘要: Nonimmunosuppressant cyclosporin derivatives having cyclophilin-binding activity, for example, the compound, �MeIle!.sup.4 -ciclosporin, are useful in inhibiting HIV-1 replication in treating AIDS and AIDS related disorders.
摘要翻译: 具有亲环素结合活性的非免疫抑制剂环孢菌素衍生物,例如化合物[MeIle] 4-环孢素,可用于抑制HIV-1复制治疗AIDS和AIDS相关疾病。
-
-