专利检索 ap:("Sorbonne Université" OR "Centre National de la Recherche Scientifique" OR "INSERM (Institut National de la Santé et de la Recherche Médicale)" OR "Ruhr-Universität Bochum" OR "Centrre Hospitalier National d'Ophtalmologie Quinze-Vingts") AND inv:"Stefan HERLITZE" 第 1 页

1.

发明公开
G-PROTEIN-GATED-K+ CHANNEL-MEDIATED ENHANCEMENTS IN LIGHT SENSITIVITY IN ROD-CONE DYSTROPHY (RCD) 审中-公开

公开(公告)号：US20230159609A1

公开(公告)日：2023-05-25

申请号：US17995880

申请日：2020-07-10

申请人： Sorbonne Université , Centre National de la Recherche Scientifique , INSERM (Institut National de la Santé et de la Recherche Médicale) , Ruhr-Universität Bochum , Centrre Hospitalier National d'Ophtalmologie Quinze-Vingts

发明人： Deniz DALKARA , Cardillia-Joe SIMON , Stefan HERLITZE , José-Alain SAHEL , Isabelle AUDO , Serge PICAUD , Stéphane Bertin

IPC分类号： C07K14/705 , C12N15/86 , C07K14/005 , A61P27/02 , A61P25/00

CPC分类号： C07K14/705 , C12N15/86 , C07K14/005 , A61P27/02 , A61P25/00 , C12N2750/14143 , C12N2750/14145 , C12N2750/14171 , C12N2750/14122 , A61K48/00

摘要： The present invention concerns a new gene therapy approach to increase light-sensitivity in degenerating cones in advanced stages of rod-cone dystrophy (RCD) mediated by G-protein-gated-K+ channel (GIRK), in particular GIRK2, activated by G proteins recruited by cone opsin expressed in degenerating cones.