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1.发明公开公开(公告)号：US20230159609A1
公开(公告)日：2023-05-25
申请号：US17995880
申请日：2020-07-10
申请人： Sorbonne Université , Centre National de la Recherche Scientifique , INSERM (Institut National de la Santé et de la Recherche Médicale) , Ruhr-Universität Bochum , Centrre Hospitalier National d'Ophtalmologie Quinze-Vingts
发明人： Deniz DALKARA , Cardillia-Joe SIMON , Stefan HERLITZE , José-Alain SAHEL , Isabelle AUDO , Serge PICAUD , Stéphane Bertin
IPC分类号： C07K14/705 , C12N15/86 , C07K14/005 , A61P27/02 , A61P25/00
CPC分类号： C07K14/705 , C12N15/86 , C07K14/005 , A61P27/02 , A61P25/00 , C12N2750/14143 , C12N2750/14145 , C12N2750/14171 , C12N2750/14122 , A61K48/00
摘要： The present invention concerns a new gene therapy approach to increase light-sensitivity in degenerating cones in advanced stages of rod-cone dystrophy (RCD) mediated by G-protein-gated-K+ channel (GIRK), in particular GIRK2, activated by G proteins recruited by cone opsin expressed in degenerating cones.
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2.发明公开公开(公告)号：US20230330440A1
公开(公告)日：2023-10-19
申请号：US18044645
申请日：2021-09-09
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
发明人： Serge PICAUD , Sara CADONI , José-Alain SAHEL , Mickaël TANTER , Charlie DEMENE
CPC分类号： A61N7/00 , C12N15/86 , A61N2007/0026 , C12N2750/14143 , A61N2007/0095
摘要： Devices and methods for reversibly stimulating neuronal cells in a subject. The devices include a module for generating ultrasounds at 4 MHz or more to stimulate neuronal cells expressing mechanosensitive channels with the ultrasounds. The methods include expressing mechanosensitive channels into neuronal cells and exposing the cells to ultrasounds at 4 MHz or more. Also, the use of the methods or devices for visual restoration in a subject.
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3.发明公开公开(公告)号：US20230172919A1
公开(公告)日：2023-06-08
申请号：US17913268
申请日：2021-03-26
申请人： SORBONNE UNIVERSITE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： A61K31/4439 , A61K9/00 , A61P27/02 , A61K45/06 , A61K31/155
CPC分类号： A61K31/4439 , A61K9/0019 , A61K9/0048 , A61K31/155 , A61K45/06 , A61P27/02
摘要： An insulin sensitizer for use in the prevention and/or treatment of the damages caused by retinal detachment, and in particular for preventing or treating the loss of vision induced by retinal detachment. Also, a composition including the insulin sensitizer for use in the prevention and/or treatment of the damages caused by retinal detachment and a device including the composition.
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公开(公告)号：US20190225649A1
公开(公告)日：2019-07-25
申请号：US16300438
申请日：2017-05-10
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
摘要： Disclosed are agents activating CD47 and their use in the treatment of inflammation, in particular non-resolving low grade inflammation, characterized by chronic MP infiltration, such as age-related macular degeneration. Also disclosed are pharmaceutical compositions, medicaments and kits including the agents.
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公开(公告)号：US20180353482A1
公开(公告)日：2018-12-13
申请号：US15777078
申请日：2016-11-17
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
发明人： Valérie FONTAINE , Cécile VIDAL , José-Alain SAHEL
IPC分类号： A61K31/426 , A61P27/02 , A61K9/00
CPC分类号： A61K31/426 , A61K9/0048 , A61K9/0053 , A61P27/02
摘要： Disclosed is a method utilizing (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or an analogue, pharmaceutically acceptable salt or solvate thereof for the treatment of a retinal disease, more specifically using mirabegron for the treatment of age-related macular degeneration. Also Disclosed is a pharmaceutical composition, a medicament and a kit for the treatment of age-related macular degeneration.
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公开(公告)号：US20180153962A1
公开(公告)日：2018-06-07
申请号：US15576027
申请日：2016-05-20
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： Thierry LEVEILLARD , John FLANNERY , Mei XIN , Leah BYRNE , José-Alain SAHEL , Emmanuelle CLERIN-LACHAPELLE , Sun JUNWEI , Jean BENNETT , Jeannette BENNICELLI
摘要： The present invention relates to the synergistic combination of the short and long Rod-Derived Cone Viability Factors and to methods for treating retinal degenerative diseases.
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公开(公告)号：US20190010235A1
公开(公告)日：2019-01-10
申请号：US16066015
申请日：2016-12-23
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSERM (Institut National de la Santé et de la Recherche Médicale)
摘要： Disclosed are agents inhibiting the interaction between CFH and CD11b/18, as well as the use of such agents, in particular for treating inflammatory disorders, such as age-related macular degeneration.
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公开(公告)号：US20160340424A1
公开(公告)日：2016-11-24
申请号：US15111986
申请日：2015-01-22
申请人： UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 (UPMC) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
CPC分类号： C07K16/248 , A61K45/00 , C07K16/2866 , C07K2317/76
摘要： The present invention relates to preventive and/or therapeutic agents for use in the treatment of retinal inflammation, and more specifically of Age-related macular degeneration and Retinitis pigmentosa, wherein said agents are selected from an IL-6 inhibitor, an APOE inhibitor and/or a Fas activator as an active ingredient.
摘要翻译： 本发明涉及用于治疗视网膜炎症的预防和/或治疗剂，更具体地涉及年龄相关性黄斑变性和色素性视网膜炎，其中所述药剂选自IL-6抑制剂，APOE抑制剂和/ 或Fas活化剂作为活性成分。
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9.发明申请METHODS FOR OBTAINING RETINAL PROGENITORS, RETINAL PIGMENTED EPITHELIAL CELLS AND NEURAL RETINAL CELLS 有权用于获得终末前列腺素，上皮细胞上皮细胞和神经细胞的方法公开(公告)号：US20160060596A1
公开(公告)日：2016-03-03
申请号：US14786427
申请日：2014-04-25
申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
IPC分类号： C12N5/079 , C12N5/0793 , C12N5/0797
CPC分类号： C12N5/0621 , C12N5/062 , C12N5/0623 , C12N2501/115 , C12N2501/42 , C12N2502/1323 , C12N2506/03 , C12N2527/00 , C12N2533/54
摘要： A method for in vitro obtaining human retinal progenitors, includes the steps of (i) placing an adherent culture of human pluripotent stem cells in a pro-neural medium; and (ii) maintaining this culture in the pro-neural medium until the appearance of pigmented cells and/or of neuroepithelial-like structures. Additional steps can be performed to obtain RPE cells and/or precursors of the neural retina.
摘要翻译： 体外获得人视网膜祖细胞的方法包括以下步骤：（i）将人多能干细胞的贴壁培养物置于前神经培养基中; 和（ii）将该培养物保持在前神经培养基中，直到着色细胞和/或神经上皮样结构的出现。 可以进行附加步骤以获得神经视网膜的RPE细胞和/或前体。
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公开(公告)号：US20230089459A1
公开(公告)日：2023-03-23
申请号：US17788534
申请日：2020-12-22
申请人： BIOPHYTIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , NSERM (INSTITUT NATIONAL DE LA SANTE ET DELA RECHERCHE ME'DICALE) , BORBONNE UNIVERSITE
发明人： Laurence DINAN , René LAFONT , Pierre DILDA , Serge CAMELO , Valérie FONTAINE , Christine BALDUCCI , Elodie MONTEIRO , Louis GUIBOUT , Mathilde LATIL , José-Alain SAHEL , Stanislas VEILLET
IPC分类号： C07C211/21 , C07D265/30 , C07D211/32 , C07D273/06 , C07D207/06 , C07D307/36 , A61P27/02
摘要： Disclosed is chemical compounds C that are derivatives of norbixin and have tropism for the eye, and are intended to be used in the treatment of eye diseases in mammals, in particular in the context of altering the retinal pigment epithelium and more particularly in the context of age-related macular degeneration (AMD) and Stargardt's disease.
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