利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

27 条记录 (耗时 0.027 秒)

    Indole derivatives as potassium channel blockers
    2.
    发明授权
    Indole derivatives as potassium channel blockers 失效
    吲哚衍生物作为钾通道阻滞剂

    公开(公告)号：US5158969A

    公开(公告)日：1992-10-27

    申请号：US748050

    申请日：1991-08-21

    申请人： Soren-Peter Olesen ,  Leif H. Jensen ,  Peter Moldt ,  Mikkel Thaning

    发明人： Soren-Peter Olesen ,  Leif H. Jensen ,  Peter Moldt ,  Mikkel Thaning

    IPC分类号： A61K31/40

    CPC分类号： A61K31/40

    摘要： A method of treating a disease in a mammal, including a human, responsive to blockade of potassium channels, which comprises administering to a mammal in need thereof an effective amount of a compound having the formula ##STR1## wherein R.sup.11, R.sup.12, R.sup.13, R.sup.14 and R.sup.15 independently of each other are hydrogen, CF.sub.3, NO.sub.2, NH.sub.2, OH, C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy or phenyl; andR.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of each other are hydrogen, halogen, CF.sub.3, C.sub.1-6 -alkyl, NO.sub.2, NH.sub.2, OH or C.sub.1-6 -alkoxy,and a method as above wherein 1-(4-methoxyphenyl)-indole is employed,and a method as above wherein depression, memory disorders, Alzheimers disease and diabetes 2 is treated,and further a method as above wherein the active ingredient is administered in the form of a pharmaceutical composition thereof, in which it is present together with a pharmaceutically-acceptable carrier or diluent.

    HYDROCHLORIDE SALT OF AN AZABICYCLO[3.2.1]OCTANE DERIVATIVE
    7.
    发明申请
    HYDROCHLORIDE SALT OF AN AZABICYCLO[3.2.1]OCTANE DERIVATIVE 有权
    亚硫酸氢盐的盐酸盐[3.2.1]月桂衍生物

    公开(公告)号：US20100056561A1

    公开(公告)日：2010-03-04

    申请号：US12529502

    申请日：2008-02-28

    申请人： Trevor John Grinter ,  Peter Moldt ,  Frank Watjen

    发明人： Trevor John Grinter ,  Peter Moldt ,  Frank Watjen

    IPC分类号： A61K31/46 ,  C07D451/02 ,  A61P25/00

    CPC分类号： C07D451/02

    摘要： The invention relates to a hydrochloride salt of (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-[(methyloxy)methyl]-8-azabicyclo[3.2.1]octane, uses of the salt as a medicament in the treatment inter alia of disorders of the central nervous system and pharmaceutical compositions and dosage forms comprising the salt.

    摘要翻译： 本发明涉及（1R，2R，3S，5S）-3-（3,4-二氯苯基）-2 - [（甲氧基）甲基] -8-氮杂双环[3.2.1]辛烷的盐酸盐， 盐作为治疗特别是中枢神经系统病症的药物以及包含该盐的药物组合物和剂型。

    1-substituted-2-(N-pheny l-N-(phenylmethyl)methanamine)-4,5-dihydro-imidazoles and related compounds and their use in treating calcium overload in brain cells
    8.
    发明授权
    1-substituted-2-(N-pheny l-N-(phenylmethyl)methanamine)-4,5-dihydro-imidazoles and related compounds and their use in treating calcium overload in brain cells 失效
    1-取代-2-（N-苯基-N-（苯甲基）甲胺）-4,5-二氢咪唑及其相关化合物及其在脑细胞中治疗钙超载中的应用

    公开(公告)号：US5296493A

    公开(公告)日：1994-03-22

    申请号：US704469

    申请日：1991-05-23

    申请人： Peter Moldt ,  Elsebet O. Nielsen

    发明人： Peter Moldt ,  Elsebet O. Nielsen

    IPC分类号： C07D233/24 ,  C07D233/54 ,  C07D233/60 ,  C07D235/14 ,  C07D401/12 ,  C07D403/06 ,  C07D405/12 ,  A61K31/415 ,  A61K31/44 ,  C07D233/61 ,  C07D401/06

    CPC分类号： C07D233/64 ,  C07D233/24 ,  C07D235/14 ,  C07D401/12 ,  C07D403/06 ,  C07D405/12

    摘要： The present patent application discloses compounds of the formula ##STR1## wherein R.sup.1 is C.sub.1-10 saturated or unsaturated alkyl; or ##STR2## wherein R'" is H or ##STR3## R.sup.2 is phenyl which is unsubstituted or substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl; benzyl which may be substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl; pyridyl; or cyclohexyl;R.sup.3 phenyl which is unsubstituted or substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl; naphthyl which may be substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl; pyridyl; C.sub.1-6 unsaturated alkyl; furanyl;R.sup.4 is H, C.sub.1-6 -alkyl, or benzyl; or ##STR4## together form ##STR5## R' and R" are each hydrogen or together form an extra benzo ring; and wherein the dotted line represents an optional extra bond between the two carbon atoms designated .alpha. and .beta.,or a pharmaceutically-acceptable addition salt thereof.The compounds are useful as pharmaceuticals, for example in the treatment of Ca overload in brain cells.

    摘要翻译： 本专利申请公开了式IMA的化合物，其中R 1是C 1-10饱和或不饱和的烷基; 或者其中R“'为H或R 2是未被取代或被卤素，CF 3，C 1-6 - 烷氧基，NO 2，CO 2 -C 1-6 - 烷基，甲基取代或被取代的苯基。 可以被卤素，CF 3，C 1-6 - 烷氧基，NO 2，CO 2 -C 1-6 - 烷基，甲基取代一次或多次的苄基; 吡啶基 或环己基; R 3苯基，其未被取代或被卤素，CF 3，C 1-6 - 烷氧基，NO 2，CO 2 -C 1-6烷基，甲基取代一次或多次; 可以被卤素，CF 3，C 1-6 - 烷氧基，NO 2，CO 2 -C 1-6 - 烷基，甲基取代一次或多次的萘基; 吡啶基 C 1-6不饱和烷基; 呋喃基 R4是H，C1-6烷基或苄基; 或一起形成 R'和R“各自为氢或一起形成额外的苯并环; 并且其中虚线表示指定为α和β的两个碳原子之间的任选的额外键或其药学上可接受的加成盐。 这些化合物可用作药物，例如用于治疗脑细胞中的Ca超载。

    Non-injection immunotherapy
    9.
    发明申请
    Non-injection immunotherapy 审中-公开
    非注射免疫治疗

    公开(公告)号：US20060269576A1

    公开(公告)日：2006-11-30

    申请号：US11140457

    申请日：2005-05-27

    申请人： Peter Moldt ,  Ove Pedersen ,  Klaus Theobald ,  Michael Flanagan

    发明人： Peter Moldt ,  Ove Pedersen ,  Klaus Theobald ,  Michael Flanagan

    IPC分类号： A61K39/35 ,  A61K39/36

    CPC分类号： A61K39/35 ,  A61K39/36 ,  A61K2039/54

    摘要： Methods and compositions are disclosed for the reduction of immune responses to an exogenous allergen. The reduction is obtained by pre-treatment or pre-conditioning, without injection, of a subject with the allergen so as to reduce immune responses in the subject upon additional exposure to the allergen. The invention is advantageously used in a variety of contexts, including seasonal allergies wherein pre-treatment or pre-conditioning is performed before the onset of the seasonal allergy.

    摘要翻译： 公开了减少对外源性变应原的免疫应答的方法和组合物。 通过预处理或预处理而不注射受试者与变应原来获得还原，以便在额外暴露于变应原时降低受试者的免疫应答。 本发明有利地用于各种情况，包括在季节性变态反应发作之前进行预处理或预处理的季节性过敏。

    Fused indole and quinoxaline derivatives, their preparation and use
    10.
    发明授权
    Fused indole and quinoxaline derivatives, their preparation and use 失效
    熔融吲哚和喹喔啉衍生物，其制备和使用

    公开(公告)号：US5801174A

    公开(公告)日：1998-09-01

    申请号：US809086

    申请日：1997-05-20

    申请人： Peter Moldt ,  Frank Watjen

    发明人： Peter Moldt ,  Frank Watjen

    IPC分类号： A61K31/40 ,  A61K31/407 ,  A61K31/435 ,  A61K31/437 ,  A61K31/55 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30 ,  A61P39/02 ,  C07D471/04 ,  C07D487/04 ,  A61K31/495

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.1 is hydrogen, alkyl or benzyl; X is O or NOR.sup.2, wherein R.sup.2 is hydrogen, alkyl or benzyl; Y is N--R.sup.4 wherein R.sup.4 is hydrogen, OH or alkyl; n is 0 or 1; R.sup.6 is phenyl which is substituted one or more times with substituents selected from the group consisting of SO.sub.2 NR'R", CONR'R", and COR'" wherein R' and R" each independently are hydrogen, alkyl, or --(CH.sub.2).sub.p --W, wherein p is 0, 1, 2, 3, 4, 5, or 6, and W is hydroxy, amino, alkoxycarbonyl, or phenyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF.sub.3, NO.sub.2, amino, alkyl, alkoxy or methylenedioxy; or wherein R' and R" together is (CH.sub.2).sub.r Z(CH.sub.2).sub.s wherein r and s each independently are 0, 1, 2, 3, 4, 5, or 6 and Z is O, S, CH.sub.2 or NR"" wherein R"" is hydrogen, alkyl, or --(CH.sub.2).sub.p --W, wherein p is 0, 1, 2, 3, 4, 5, or 6, and W is hydroxy, amino, alkoxycarbonyl, or phenyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF.sub.3, NO.sub.2, amino, alkyl, alkoxy or methylenedioxy; and wherein R'" is hydrogen, alkyl, alkoxy or phenyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF.sub.3, NO.sub.2, amino, alkyl, alkoxy or methylenedioxy; A is a ring of five to seven atoms fused with the benzo ring at the positions marked a and b. The compounds are useful in the treatment of cerebrovascular disorders for example.

    摘要翻译： PCT No.PCT / EP95 / 03594 371日期1997年5月20日 102（e）日期1997年5月20日PCT提交1995年9月12日PCT公布。 出版物WO96 / 08495 日本特开1996年3月21日本专利申请公开了具有式“IMAGE”的化合物或其药学上可接受的盐，其中R 1是氢，烷基或苄基; X是O或NOR2，其中R2是氢，烷基或苄基; Y是N-R4，其中R4是氢，OH或烷基; n为0或1; R6是被选自SO2NR'R“，CONR'R”和COR“的取代基一次或多次的苯基，其中R'和R”各自独立地是氢，烷基或 - （CH 2）p W，其中p是0,1,2,3,4,5或6，并且W是羟基，氨基，烷氧基羰基或苯基，其可以被选自以下的取代基取代一次或多次： 的卤素，CF 3，NO 2，氨基，烷基，烷氧基或亚甲二氧基; 或其中R'和R“一起是（CH 2）rZ（CH 2）s，其中r和s各自独立地是0,1,2,3,4,5或6，Z是O，S，CH 2或NR' “其中R”“是氢，烷基或 - （CH 2）p W，其中p是0,1,2,3,4,5或6，并且W是羟基，氨基，烷氧基羰基或苯基 其可以被选自卤素，CF 3，NO 2，氨基，烷基，烷氧基或亚甲二氧基的取代基取代一次或多次; 并且其中R“是氢，烷基，烷氧基或苯基，其可以被选自卤素，CF 3，NO 2，氨基，烷基，烷氧基或亚甲二氧基的取代基取代一次或多次; A是在标记a和b的位置与苯环稠合的5至7个原子的环。 该化合物可用于治疗例如脑血管障碍。