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    Indole derivatives as potassium channel blockers
    2.
    发明授权
    Indole derivatives as potassium channel blockers 失效
    吲哚衍生物作为钾通道阻滞剂

    公开(公告)号：US5158969A

    公开(公告)日：1992-10-27

    申请号：US748050

    申请日：1991-08-21

    申请人： Soren-Peter Olesen ,  Leif H. Jensen ,  Peter Moldt ,  Mikkel Thaning

    发明人： Soren-Peter Olesen ,  Leif H. Jensen ,  Peter Moldt ,  Mikkel Thaning

    IPC分类号： A61K31/40

    CPC分类号： A61K31/40

    摘要： A method of treating a disease in a mammal, including a human, responsive to blockade of potassium channels, which comprises administering to a mammal in need thereof an effective amount of a compound having the formula ##STR1## wherein R.sup.11, R.sup.12, R.sup.13, R.sup.14 and R.sup.15 independently of each other are hydrogen, CF.sub.3, NO.sub.2, NH.sub.2, OH, C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy or phenyl; andR.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of each other are hydrogen, halogen, CF.sub.3, C.sub.1-6 -alkyl, NO.sub.2, NH.sub.2, OH or C.sub.1-6 -alkoxy,and a method as above wherein 1-(4-methoxyphenyl)-indole is employed,and a method as above wherein depression, memory disorders, Alzheimers disease and diabetes 2 is treated,and further a method as above wherein the active ingredient is administered in the form of a pharmaceutical composition thereof, in which it is present together with a pharmaceutically-acceptable carrier or diluent.

    Benzimidazole derivatives, their preparation and use
    3.
    发明授权
    Benzimidazole derivatives, their preparation and use 失效
    苯并咪唑衍生物，其制备和用途

    公开(公告)号：US5200422A

    公开(公告)日：1993-04-06

    申请号：US731412

    申请日：1991-07-17

    申请人： Soren-Peter Olesen ,  Frank Watjen

    发明人： Soren-Peter Olesen ,  Frank Watjen

    IPC分类号： C07D235/26 ,  C07D235/28 ,  C07D235/30

    CPC分类号： C07D235/28 ,  C07D235/26 ,  C07D235/30

    摘要： A compound having the formula ##STR1## wherein R.sup.1 is hydrogen, NH.sub.2 or C.sub.1-6 -alkyl which may be branched;X is O, S, NCN;Y is O, S;R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of each other are hydrogen, halogen, CF.sub.3, NO.sub.2, NH.sub.2, OH, C.sub.1-6 -alkoxy, C(.dbd.O)-phenyl or SO.sub.2 NR.sup.I R.sup.II wherein R.sup.I and R.sup.II independently are hydrogen or C.sub.1-6 -alkyl;R.sup.11 is hydrogen, halogen, NO.sub.2 or SO.sub.2 NR'R" wherein R' and R" independently are hydrogen or C.sub.1-6 -alkyl;R.sup.13 is hydrogen, halogen, phenyl, CF.sub.3, NO.sub.2 ;R.sup.12 is hydrogen or together with R.sup.13 forms a C.sub.4-7 -carbocyclic ring which may be aromatic or partially saturated;R.sup.14 is hydrogen or together with R.sup.13 forms a C.sub.4-7 -carbocyclic ring which may be aromatic or partially saturated;pharmaceutical compositions thereof,and a method of treating a disease in a mammal, including a human, responsive to opening of potassium channels, which comprises administering to a mammal in need thereof an effective amount of a compound as first above indicated, are disclosed.

    摘要翻译： 具有式“IMAGE”的化合物，其中R 1是氢，NH 2或可以是支链的C 1-6 - 烷基; X为O，S，NCN; Y是O，S; R4，R5，R6和R7彼此独立地是氢，卤素，CF3，NO2，NH2，OH，C1-6 - 烷氧基，C（= O） - 苯基或SO2NRIRII，其中RI和RII独立地是氢或C1-6 -烷基; R11是氢，卤素，NO2或SO2NR'R“，其中R'和R”独立地是氢或C1-6烷基; R 13是氢，卤素，苯基，CF 3，NO 2; R 12是氢或与R 13一起形成可以是芳族或部分饱和的C 4-7 - 碳环; R 14是氢或与R 13一起形成可以是芳族或部分饱和的C 4-7 - 碳环; 其药物组合物，以及治疗包括人的哺乳动物（包括人）在开放钾通道中的疾病的方法，该方法包括对有需要的哺乳动物施用有效量的如上所述的化合物。

    Automatic electrode positioning apparatus
    4.
    发明授权
    Automatic electrode positioning apparatus 有权
    自动电极定位装置

    公开(公告)号：US06470226B1

    公开(公告)日：2002-10-22

    申请号：US09400283

    申请日：1999-09-21

    申请人： Soren-Peter Olesen ,  Palle Christophersen ,  Morten Bech

    发明人： Soren-Peter Olesen ,  Palle Christophersen ,  Morten Bech

    IPC分类号： G05B1918

    CPC分类号： G01N33/48728

    摘要： The present invention relates to an automatic electrode position apparatus for connecting an electrode to a cell. The invention further provides methods for utilizing the apparatus of the invention. Apparatus and methods are described for studying electrical activities in cell membranes. These methods are especially useful in large scale screening programs in the pharmaceutical industry.

    摘要翻译： 本发明涉及一种用于将电极连接到电池的自动电极位置装置。 本发明还提供了利用本发明装置的方法。 描述了用于研究细胞膜中电活动的装置和方法。 这些方法在制药行业的大规模筛选项目中特别有用。