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    HYDROXYBENZOATE SALTS OF METANICOTINE COMPOUNDS
    8.
    发明申请
    HYDROXYBENZOATE SALTS OF METANICOTINE COMPOUNDS 审中-公开
    金属化合物的羟基苯甲酸盐

    公开(公告)号：US20080249142A1

    公开(公告)日：2008-10-09

    申请号：US12142471

    申请日：2008-06-19

    申请人： Gary Maurice Dull ,  Julio A. Munoz ,  John Genus ,  James R. Moore

    发明人： Gary Maurice Dull ,  Julio A. Munoz ,  John Genus ,  James R. Moore

    IPC分类号： A61K31/44 ,  A61P25/00 ,  A61P25/28 ,  A61P25/16

    CPC分类号： C07D213/38 ,  C07D213/65 ,  C07D213/73 ,  C07D213/75 ,  C07D401/12

    摘要： Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, as the hydroxybenzoate salts tend to crystallize out, leaving impurities such as Z-metanicotine compounds, and compounds where the double bond has migrated, in solution. If desired, the hydroxybenzoate salts can be converted to either the free base (the E-metanicotine compound) or to another pharmaceutically acceptable salt form.

    摘要翻译： 通过向有需要的患者施用作为E-间断脒类化合物的羟基苯甲酸盐的组合物来治疗易患或患有病症和障碍的患者，例如中枢神经系统疾病。 E-间烟碱化合物的羟基苯甲酸盐的形成也可用于纯化E-间烟碱化合物，因为羟基苯甲酸盐倾向于结晶出来，留下杂质如Z-间苯ic啶化合物和双键已经迁移的化合物 解。 如果需要，羟基苯甲酸盐可以转化为游离碱（E-间烟碱化合物）或另一种药学上可接受的盐形式。

    (2S, 3R)-N-(2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)BENZOFURAN-2-CARBOXAMIDE, NOVEL SALT FORMS, AND METHODS OF USE THEREOF
    10.
    发明申请
    (2S, 3R)-N-(2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)BENZOFURAN-2-CARBOXAMIDE, NOVEL SALT FORMS, AND METHODS OF USE THEREOF 有权
    （2S，3R）-N-（2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2] OCT-3-YL）苯并呋喃-2-羧酰胺，新型盐形式及其使用方法

    公开(公告)号：US20110263859A1

    公开(公告)日：2011-10-27

    申请号：US13116163

    申请日：2011-05-26

    申请人： Gary Maurice Dull ,  John Genus ,  Jacob Mathew

    发明人： Gary Maurice Dull ,  John Genus ,  Jacob Mathew

    IPC分类号： C07D453/02

    CPC分类号： C07D453/02 ,  A61K31/439

    摘要： The present invention relates to (2S,3R)-N-(2((3-pyridiny)triethyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central and autonomic nervous systems.

    摘要翻译： 本发明涉及（2S，3R）-N-（2（（3-吡啶基）三乙基）-1-氮杂双环[2.2.2]辛-3-基）苯并呋喃-2-甲酰胺，其新的盐形式， 用于其制备，新型中间体和用于治疗各种各样的病症和障碍的方法，包括与中枢和自主神经系统的功能障碍相关的那些。