Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
    10.
    发明授权
    Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof 有权
    生育酚,生育三烯酚,其他色满反应和侧链衍生物及其用途

    公开(公告)号:US06645998B2

    公开(公告)日:2003-11-11

    申请号:US10122019

    申请日:2002-04-12

    IPC分类号: A61K31355

    摘要: The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers and nitriles; R2 is hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R3 is selected from the group consisting of hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R4 is of methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; and R5 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxyl, amide and ester. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.

    摘要翻译: 本发明提供了具有结构式的结构的抗增殖化合物,X是氧,氮或硫; R 1是烷基,烯基,炔基,芳基,杂芳基,羧酸,羧酸酯,羧酰胺,酯,硫代酰胺,硫醇酸,硫醇酯,糖,烷氧基连接的糖,胺,磺酸酯,硫酸酯,磷酸酯,醇,醚和腈 ; R 2是氢,甲基,苄基羧酸,苄基羧酸酯,苄基甲酰胺,苄基酯,糖和胺; R 3选自氢,甲基,苄基羧酸,苄基羧酸酯,苄基甲酰胺,苄基酯,糖和胺; R 4为甲基,苄基羧酸,苄基羧酸酯,苄基甲酰胺,苄基酯,糖和胺; R 5为烷基,烯基,炔基,芳基,杂芳基,羧基,酰胺和酯。 还提供了诱导细胞凋亡的方法,包括给予包含化合物的组合物。