公开(公告)号：US07166423B1

公开(公告)日：2007-01-23

申请号：US08416920

申请日：1993-10-21

申请人： Stefan Miltenyi ,  Andreas Radbruch ,  Rudi Manz

发明人： Stefan Miltenyi ,  Andreas Radbruch ,  Rudi Manz

IPC分类号： G01N33/53 ,  G01N33/68 ,  G01N33/563

CPC分类号： G01N33/5005 ,  G01N33/554 ,  G01N33/58 ,  Y10S435/961 ,  Y10S435/972 ,  Y10S435/975 ,  Y10S436/824

摘要： Cells can be labeled with products which they secrete and release in an efficient manner by coupling the cells at their surface to a specific binding partner for the product and allowing the product to be captured by the specific binding partner as it is secreted and released. The product-labeled cells can then be further coupled to suitable labels, if desired, and separated according to the presence, absence, or amount of product.

摘要翻译： 细胞可以通过将其表面上的细胞与产物的特异性结合配偶体偶联而以有效的方式分泌和释放的产物进行标记，并允许产物在分泌和释放时被特异性结合配偶体捕获。 然后，如果需要，将产物标记的细胞进一步偶合到合适的标记上，并根据产品的存在，不存在或数量分离。

公开(公告)号：US20060141540A1

公开(公告)日：2006-06-29

申请号：US11359328

申请日：2006-02-21

申请人： Stefan Miltenyi ,  Andreas Radbruch ,  Rudi Manz

发明人： Stefan Miltenyi ,  Andreas Radbruch ,  Rudi Manz

IPC分类号： G01N33/567 ,  C12N5/06

CPC分类号： G01N33/5005 ,  G01N33/53 ,  G01N33/56966 ,  G01N33/56972 ,  G01N33/58

摘要： Cells can be labeled with products which they secrete and release in an efficient manner by coupling the cells at their surface to a specific binding partner for the product and allowing the product to be captured by the specific binding partner as it is secreted and released. The product-labeled cells can then be further coupled to suitable labels, if desired, and separated according to the presence, absence, or amount of product.

摘要翻译： 细胞可以通过将其表面上的细胞与产物的特异性结合配偶体偶联而以有效的方式分泌和释放的产物进行标记，并允许产物在分泌和释放时被特异性结合配偶体捕获。 然后，如果需要，将产物标记的细胞进一步偶合到合适的标记上，并根据产品的存在，不存在或数量分离。