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公开(公告)号：US20080312268A1
公开(公告)日：2008-12-18
申请号：US12143614
申请日：2008-06-20
IPC分类号： A61K31/439 , C07D221/22 , A61P25/32 , A61P25/30 , A61P25/00
CPC分类号： C07D471/08
摘要： Substituted tricyclic piperidone derivatives corresponding to Formula I: a method for producing such compounds; pharmaceutical compositions containing such compounds, and the use of such compounds to treat pain, depression, urinary incontinence, diarrhea, pruritus, alcohol and drug abuse, drug dependency, lethargy and/or anxiety.
摘要翻译： 对应于式I的取代的三环哌啶酮衍生物：这种化合物的制备方法; 含有这些化合物的药物组合物，以及这些化合物用于治疗疼痛，抑郁症，尿失禁，腹泻，瘙痒，酒精和药物滥用，药物依赖性，嗜睡和/或焦虑症的用途。
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公开(公告)号：US08106055B2
公开(公告)日：2012-01-31
申请号：US12112406
申请日：2008-04-30
申请人： Stefan Oberboersch , Melanie Reich , Bernd Sundermann , Utz-Peter Jagusch , Beatrix Merla , Stefan Schunk , Werner Englberger , Timo Struenker , Hagen-Heinrich Hennies , Edward Bijsterveld , Fritz Theil , Heinz Graubaum
发明人： Stefan Oberboersch , Melanie Reich , Bernd Sundermann , Utz-Peter Jagusch , Beatrix Merla , Stefan Schunk , Werner Englberger , Timo Struenker , Hagen-Heinrich Hennies , Edward Bijsterveld , Fritz Theil , Heinz Graubaum
IPC分类号： A61K31/497 , A61K31/47 , C07D401/12 , C07D215/08
CPC分类号： C07D207/04 , C07C233/56 , C07C235/20 , C07C235/22 , C07C311/17 , C07C311/20 , C07C311/29 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D211/08 , C07D333/20 , C07D409/04
摘要： Substituted amide compounds corresponding to formula I: processes for preparing them, pharmaceutical compositions containing these compounds, and the use of substituted amide derivatives for the preparation of medicaments for the treatment of pain and various other conditions.
摘要翻译： 对应于式I的取代的酰胺化合物：其制备方法，含有这些化合物的药物组合物，以及使用取代的酰胺衍生物制备用于治疗疼痛和各种其它病症的药物。
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公开(公告)号：US20080306084A1
公开(公告)日：2008-12-11
申请号：US12112406
申请日：2008-04-30
申请人： Stefan Oberboersch , Melanie Reich , Bernd Sundermann , Utz-Peter Jagusch , Beatrix Merla , Stefan Schunk , Werner Englberger , Timo Struenker , Hagen-Heinrich Hennies , Edward Bijsterveld , Fritz Theil , Heinz Graubaum
发明人： Stefan Oberboersch , Melanie Reich , Bernd Sundermann , Utz-Peter Jagusch , Beatrix Merla , Stefan Schunk , Werner Englberger , Timo Struenker , Hagen-Heinrich Hennies , Edward Bijsterveld , Fritz Theil , Heinz Graubaum
IPC分类号： A61K31/496 , C07D215/36 , A61K31/47 , C07D401/06
CPC分类号： C07D207/04 , C07C233/56 , C07C235/20 , C07C235/22 , C07C311/17 , C07C311/20 , C07C311/29 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D211/08 , C07D333/20 , C07D409/04
摘要： Substituted amide compounds corresponding to formula I: processes for preparing them, pharmaceutical compositions containing these compounds, and the use of substituted amide derivatives for the preparation of medicaments for the treatment of pain and various other conditions.
摘要翻译： 对应于式I的取代的酰胺化合物：其制备方法，含有这些化合物的药物组合物，以及使用取代的酰胺衍生物制备用于治疗疼痛和各种其它病症的药物。
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公开(公告)号：US08058475B2
公开(公告)日：2011-11-15
申请号：US12143433
申请日：2008-06-20
申请人： Stefan Oberboersch , Beatrix Merla , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Achim Kless , Petra Bloms-Funke , Babette-Yvonne Koegel , Heinze Graubaum
发明人： Stefan Oberboersch , Beatrix Merla , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Achim Kless , Petra Bloms-Funke , Babette-Yvonne Koegel , Heinze Graubaum
IPC分类号： C07C251/34 , A61K31/15
CPC分类号： C07C211/26 , C07C211/29 , C07C211/40 , C07C233/06 , C07C233/13 , C07C233/18 , C07C233/65 , C07C233/66 , C07C233/73 , C07C251/42 , C07C251/44 , C07C275/26 , C07C311/20 , C07C311/29 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D209/14 , C07D333/14 , C07D333/22 , C07D409/12
摘要： Novel cyclohexylmethyl compounds corresponding to formula I wherein R1, R2, R3, R4 and R5, have the meanings given in the description. Pharmaceutical formulations containing these compounds, as well as a processes for preparing these compounds and related methods of treatment are also provided.
摘要翻译： 对应于式I的新型环己基甲基化合物，其中R 1，R 2，R 3，R 4和R 5具有在说明书中给出的含义。 还提供了含有这些化合物的药物制剂，以及制备这些化合物的方法和相关的治疗方法。
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公开(公告)号：US07728028B2
公开(公告)日：2010-06-01
申请号：US12143566
申请日：2008-06-20
申请人： Beatrix Merla , Stefan Oberboersch , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Heinz Graubaum
发明人： Beatrix Merla , Stefan Oberboersch , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Heinz Graubaum
IPC分类号： A61K31/4164 , C07D233/06 , A61P25/30 , A61P25/24
CPC分类号： C07D233/28
摘要： Substituted imidazoline derivatives corresponding to Formula I: a method for producing them from substituted aldehyde compounds of Formula B: and the use of such imidazoline derivatives and aldehyde compounds to treat pain, depression, urinary incontinence, diarrhea, pruritus, alcohol and drug misuse, drug dependency, lethargy and/or anxiety.
摘要翻译： 对应于式I的取代的咪唑啉衍生物：由式B的取代的醛化合物制备它们的方法：以及使用这些咪唑啉衍生物和醛化合物来治疗疼痛，抑郁症，尿失禁，腹泻，瘙痒，酒精和药物滥用，药物 依赖，嗜睡和/或焦虑。
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公开(公告)号：US07608619B2
公开(公告)日：2009-10-27
申请号：US12143519
申请日：2008-06-20
申请人： Beatrix Merla , Stefan Oberboersch , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Heinz Graubaum
发明人： Beatrix Merla , Stefan Oberboersch , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Heinz Graubaum
IPC分类号： A61K31/5377 , A61K31/421 , A61K31/454 , C07D413/02 , C07D413/14 , C07D263/48
CPC分类号： C07D263/48 , C07D413/04 , C07D413/06 , C07D413/14
摘要： Substituted oxazole derivatives corresponding to formula I: a method for producing such compounds, pharmaceutical compositions containing such compounds, and the use of such compounds to treat pain, depression, urinary incontinence, diarrhoea, pruritus, alcohol and drug misuse, drug dependency, lethargy and/or anxiety.
摘要翻译： 对应于式I的取代的恶唑衍生物：制备这种化合物的方法，含有这些化合物的药物组合物，以及这些化合物用于治疗疼痛，抑郁症，尿失禁，腹泻，瘙痒，酒精和药物滥用，药物依赖性，嗜睡和 /或焦虑。
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7.发明申请1,3-Disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their Use in Medicaments 有权1,3-二取代的4-甲基-1H-吡咯-2-甲酰胺及其在药物中的用途公开(公告)号：US20090137573A1
公开(公告)日：2009-05-28
申请号：US12331011
申请日：2008-12-09
申请人： Stefan Oberboersch , Bernd Sundermann , Corinna Sundermann , Edward Bijsterveld , Hagen-Heinrich Hennies
发明人： Stefan Oberboersch , Bernd Sundermann , Corinna Sundermann , Edward Bijsterveld , Hagen-Heinrich Hennies
IPC分类号： A61K31/541 , C07D417/02 , A61K31/433 , A61K31/5377 , A61P25/00 , C07D413/02 , C07D295/14 , A61K31/40
CPC分类号： C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D417/12
摘要： 1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides corresponding to formula I methods for their production, pharmaceutical compositions containing them, and the use thereof for noradrenalin receptor regulation, particularly for inhibiting noradrenalin reuptake, and/or for 5-HT receptor regulation, particularly for inhibiting 5-hydroxy tryptophan reuptake, and/or for opioid receptor regulation and/or for batrachotoxin (BTX) receptor regulation and/or for treating or inhibiting pain and other conditions.
摘要翻译： 对应于式I制备方法的1,3-二取代4-甲基-1H-吡咯-2-甲酰胺，含有它们的药物组合物及其用于去甲肾上腺素受体调节的用途，特别是用于抑制去甲肾上腺素再摄取和/或5 -HT受体调节，特别是用于抑制5-羟色氨酸再摄取和/或用于阿片样物质受体调节和/或蝙蝠素激素（BTX）受体调节和/或用于治疗或抑制疼痛和其它病症。
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![Substituted C-imidazo[1,2-a]pyridin-3-yl-methylamines](/abs-image/US/2008/03/11/US07342025B2/abs.jpg.150x150.jpg)
公开(公告)号：US07342025B2
公开(公告)日：2008-03-11
申请号：US11100535
申请日：2005-04-07
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02
CPC分类号： C07D471/04
摘要： Substituted C-imidazo [1,2-a]pyridine-3-yl methylamines and physiologically acceptable salts thereof, a method for the production thereof, pharmaceutical compositions containing these compounds, and pharmaceutical uses thereof, e.g., as NO synthase inhibitors.
摘要翻译： 取代的C-咪唑并[1,2-a]吡啶-3-基甲胺及其生理学上可接受的盐，其制备方法，含有这些化合物的药物组合物及其药物用途，例如NO合成酶抑制剂。
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![Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds](/abs-image/US/2007/10/25/US20070249631A1/abs.jpg.150x150.jpg)
9.发明申请Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds 有权取代的5,6,7,8-四氢吡啶并[4,3-d]嘧啶-2-基化合物和5,6,7,8-四氢喹唑啉-2-基化合物公开(公告)号：US20070249631A1
公开(公告)日：2007-10-25
申请号：US11588238
申请日：2006-10-27
申请人： Stefan Oberboersch , Bernd Sundermann , Corinna Sundermann , Michael Haurand , Hagen-Heinrich Hennies , Edward Bijsterveld
发明人： Stefan Oberboersch , Bernd Sundermann , Corinna Sundermann , Michael Haurand , Hagen-Heinrich Hennies , Edward Bijsterveld
IPC分类号： C07D471/04 , C07D239/70 , C07D471/00
CPC分类号： C07D239/84 , C07D409/12 , C07D471/04
摘要： Substituted 5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl and 5,6,7,8-tetrahydro-quinazolin-2-yl compounds, corresponding to formula I processes for the production thereof, pharmaceutical preparations containing these compounds the use thereof for the production of pharmaceutical preparations and related method of treating or inhibiting certain disorders or conditions, including pain.
摘要翻译： 取代的5,6,7,8-四氢 - 吡啶并[4,3-d]嘧啶-2-基和5,6,7,8-四氢 - 喹唑啉-2-基化合物，对应于式I生产方法 含有这些化合物的药物制剂用于制备药物制剂及其治疗或抑制某些疾病或病症（包括疼痛）的相关方法。
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10.发明授权1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their use in medicaments 有权1,3-二取代的4-甲基-1H-吡咯-2-甲酰胺及其在药物中的用途公开(公告)号：US07968591B2
公开(公告)日：2011-06-28
申请号：US12331011
申请日：2008-12-09
申请人： Stefan Oberboersch , Bernd Sundermann , Corinna Sundermann , Edward Bijsterveld , Hagen-Heinrich Hennies
发明人： Stefan Oberboersch , Bernd Sundermann , Corinna Sundermann , Edward Bijsterveld , Hagen-Heinrich Hennies
IPC分类号： A61K31/551 , A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/454 , A61K31/433 , A61K31/4178 , A61K31/404 , A61K31/4025 , A61K31/40 , C07D417/12 , C07D413/04 , C07D405/04 , C07D407/04 , C07D401/14 , C07D401/12 , C07D401/06 , C07D403/12 , C07D207/34
CPC分类号： C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D417/12
摘要： 1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides corresponding to formula I methods for their production, pharmaceutical compositions containing them, and the use thereof for noradrenalin receptor regulation, particularly for inhibiting noradrenalin reuptake, and/or for 5-HT receptor regulation, particularly for inhibiting 5-hydroxy tryptophan reuptake, and/or for opioid receptor regulation and/or for batrachotoxin (BTX) receptor regulation and/or for treating or inhibiting pain and other conditions.
摘要翻译： 对应于式I制备方法的1,3-二取代4-甲基-1H-吡咯-2-甲酰胺，含有它们的药物组合物及其用于去甲肾上腺素受体调节的用途，特别是用于抑制去甲肾上腺素再摄取和/或5 -HT受体调节，特别是用于抑制5-羟色氨酸再摄取和/或用于阿片样物质受体调节和/或蝙蝠素激素（BTX）受体调节和/或用于治疗或抑制疼痛和其它病症。
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