专利检索 cpc:"C07C211/26" 第 1 页

1.

发明授权
Process for the preparation of substituted pyrimidine derivatives 有权

公开(公告)号：US09359327B2

公开(公告)日：2016-06-07

申请号：US14079358

申请日：2013-11-13

申请人： Janssen Pharmaceutica NV

发明人： Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao

IPC分类号： C07D239/02 , C07D239/42 , C07D413/02 , C07D213/56 , C07D401/12 , C07D211/22 , C07D211/26 , C07C211/22 , C07C211/26

CPC分类号： C07D401/12 , C07C211/22 , C07C211/26 , C07D211/22 , C07D211/26

摘要： The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.

2.

发明授权
Process for the preparation of substituted pyrimidine derivatives 有权
标题翻译：制备取代嘧啶衍生物的方法

公开(公告)号：US09006432B2

公开(公告)日：2015-04-14

申请号：US14078153

申请日：2013-11-12

申请人： Janssen Pharmaceutica NV

发明人： Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Daniel J. Pippel

IPC分类号： C07D239/02 , C07D401/12 , C07C211/22 , C07C211/26

CPC分类号： C07D401/12 , C07C211/22 , C07C211/26 , C07D211/22 , C07D211/26

摘要： The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.

摘要翻译： 本发明涉及制备用作合成组胺H 4受体调节剂的中间体的取代嘧啶衍生物的方法，以及H4调节剂合成中的中间体。

3.

发明申请
Process for the preparation of substituted pyrimidine derivatives 审中-公开

公开(公告)号：US20130225816A1

公开(公告)日：2013-08-29

申请号：US13844227

申请日：2013-03-15

申请人： Janssen Pharmaceutica NV

发明人： Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao

IPC分类号： C07D401/12

CPC分类号： C07D401/12 , C07C211/22 , C07C211/26 , C07D211/22 , C07D211/26

摘要： The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.

4.

发明申请
Process for the preparation of substituted pyrimidine derivatives 审中-公开

公开(公告)号：US20130053561A1

公开(公告)日：2013-02-28

申请号：US13663233

申请日：2012-10-29

申请人： Janssen Pharmaceutica NV

发明人： Sergio CESCO-CANCIAN , Hongfeng CHEN , Jeffrey S. GRIMM , Neelakandha S. MANI , Christopher M. MAPES , David C. PALMER , Daniel J. PIPPEL , Kirk L. SORGI , Tong XIAO

IPC分类号： C07D401/12

CPC分类号： C07D401/12 , C07C211/22 , C07C211/26 , C07D211/22 , C07D211/26

摘要： The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.

5.

发明授权
Production of cyclohexylamine 失效
标题翻译：生产环己胺

公开(公告)号：US4384142A

公开(公告)日：1983-05-17

申请号：US271869

申请日：1981-06-09

申请人： Helmut L. Merten , Gene R. Wilder

发明人： Helmut L. Merten , Gene R. Wilder

IPC分类号： C07B61/00 , B01J20060101 , B01J23/00 , B01J23/46 , C07C20060101 , C07C67/00 , C07C209/00 , C07C209/24 , C07C209/72 , C07C211/26 , C07C211/35 , C07C85/24

CPC分类号： C07C209/72 , B01J21/18 , B01J23/462 , B01J38/04 , C07C209/00 , C07C209/24 , C07C211/26 , C07C211/35 , C07C2101/08 , C07C2101/14 , Y02P20/584

摘要： Cyclohexylamine is produced by the catalytic hydrogenation of aniline. In contact with a ruthenium catalyst and in the presence of from about one to about 8 parts by weight of ammonia, aniline is hydrogenated under an absolute pressure of from about 2 to about 5 MPa at a temperature of from about 160.degree. to about 180.degree. C. High yields and a minimum of byproducts result. The catalyst can be recycled.

摘要翻译： 环己胺通过苯胺的催化氢化生产。在与钌催化剂接触并且在约1至约8重量份氨存在下，苯胺在约2至约5MPa的绝对压力下在约160至约180℃的温度下氢化 C.产量高，副产物最少。催化剂可以回收利用。

6.

发明授权
Methods of using cycloalkylmethylamine derivatives 有权
标题翻译：使用环烷基甲胺衍生物的方法

公开(公告)号：US09096515B2

公开(公告)日：2015-08-04

申请号：US14038543

申请日：2013-09-26

申请人： Reviva Pharmaceuticals, Inc.

发明人： Laxminarayan Bhat , Kouacou Adiey

IPC分类号： C07C211/00 , A01N33/02 , A61K31/135 , C07C69/34 , C07C209/48 , C07C209/88 , C07C211/26 , C07C213/06 , C07C213/10 , C07C217/74 , C07C219/06 , C07C231/02 , C07C237/06 , C07C271/20 , C07C229/34 , C07C69/96 , C07C237/22

CPC分类号： C07C69/34 , C07C69/96 , C07C209/48 , C07C209/88 , C07C211/26 , C07C213/06 , C07C213/10 , C07C217/74 , C07C219/06 , C07C229/34 , C07C231/02 , C07C237/06 , C07C237/22 , C07C271/20 , C07C2601/04

摘要： The present invention provides novel cycloalkylmethylamine derivatives, and methods of preparing cycloalkylmethylamine derivatives. The present invention also provides methods of using cycloalkylmethylamine derivatives and compositions of cycloalkylmethylamine derivatives. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications and depression and depression related co-morbid indications.

摘要翻译： 本发明提供新的环烷基甲基胺衍生物，以及制备环烷基甲基胺衍生物的方法。本发明还提供了使用环烷基甲基胺衍生物和环烷基甲基胺衍生物的组合物的方法。本发明化合物的药物组合物可以有利地用于治疗和/或预防肥胖和肥胖相关并发症适应症和抑郁症和抑郁症相关并发症的适应症。

7.

发明授权
Process for the preparation of substituted pyrimidine derivatives 有权

公开(公告)号：US09079884B2

公开(公告)日：2015-07-14

申请号：US14076955

申请日：2013-11-11

申请人： Janssen Pharmaceutica NV

发明人： Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao

IPC分类号： C07D401/12 , C07D211/22 , C07D211/26

CPC分类号： C07D401/12 , C07C211/22 , C07C211/26 , C07D211/22 , C07D211/26

摘要： The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.

8.

发明申请
Compositions, Synthesis, and Methods of Using Cycloalkylmethylamine Derivatives 有权
标题翻译：使用环烷基甲基胺衍生物的组合物，合成和方法

公开(公告)号：US20120172426A1

公开(公告)日：2012-07-05

申请号：US13175824

申请日：2011-07-01

申请人： Laxminarayan Bhat , Kouacou Adiey

发明人： Laxminarayan Bhat , Kouacou Adiey

IPC分类号： A61K31/27 , A61K31/215 , C07C271/20 , A61P25/24 , A61K31/165 , C07C69/96 , A61K31/265 , A61P3/04 , C07C69/34 , C07C237/22

CPC分类号： C07C69/34 , C07C69/96 , C07C209/48 , C07C209/88 , C07C211/26 , C07C213/06 , C07C213/10 , C07C217/74 , C07C219/06 , C07C229/34 , C07C231/02 , C07C237/06 , C07C237/22 , C07C271/20 , C07C2601/04

摘要： The present invention provides novel cycloalkylmethylamine derivatives, and methods of preparing cycloalkylmethylamine derivatives. The present invention also provides methods of using cycloalkylmethylamine derivatives and compositions of cycloalkylmethylamine derivatives. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications and depression and depression related co-morbid indications.

摘要翻译： 本发明提供新的环烷基甲基胺衍生物，以及制备环烷基甲基胺衍生物的方法。本发明还提供了使用环烷基甲基胺衍生物和环烷基甲基胺衍生物的组合物的方法。本发明化合物的药物组合物可以有利地用于治疗和/或预防肥胖和肥胖相关并发症适应症和抑郁症和抑郁症相关并发症的适应症。