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公开(公告)号:US20110229475A1
公开(公告)日:2011-09-22
申请号:US12596262
申请日:2008-04-16
申请人: Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
发明人: Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
IPC分类号: A61K39/395 , C07K16/24 , A61P19/02 , A61P9/10 , A61P11/06 , A61P17/06 , C12P21/08 , C12N5/10 , C12N1/00 , C12N5/12 , C12N15/63 , C12P21/02 , A61P19/06 , A61P35/00 , A61P11/00 , A61P7/00 , A61P9/00 , A61P29/00
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/24 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/76
摘要: The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78.
摘要翻译: 本发明涉及具有多种特异性的抗体。 特别地,本发明的抗体与人IL-8,Gro-α,Gro-β,Gro-γ和ENA-78结合(交叉反应)。
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公开(公告)号:US08496932B2
公开(公告)日:2013-07-30
申请号:US12596262
申请日:2008-04-16
申请人: Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
发明人: Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
IPC分类号: A61K39/395
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/24 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/76
摘要: The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78.
摘要翻译: 本发明涉及具有多种特异性的抗体。 特别地,本发明的抗体与人IL-8,Gro-α,Gro-β,Gro-γ和ENA-78结合(交叉反应)。
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公开(公告)号:US20080262203A1
公开(公告)日:2008-10-23
申请号:US12103761
申请日:2008-04-16
申请人: Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
发明人: Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/24 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/76
摘要: The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78.
摘要翻译: 本发明涉及具有多种特异性的抗体。 特别地,本发明的抗体与人IL-8,Gro-α,Gro-β,Gro-γ和ENA-78结合(交叉反应)。
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公开(公告)号:US5502167A
公开(公告)日:1996-03-26
申请号:US244626
申请日:1994-07-15
申请人: Herman Waldmann , Louise Walsh , James S. Crowe , Alan P. Lewis
发明人: Herman Waldmann , Louise Walsh , James S. Crowe , Alan P. Lewis
IPC分类号: C12N15/09 , A61K38/00 , A61K39/395 , A61P37/06 , C07K14/725 , C07K16/00 , C07K16/18 , C07K16/28 , C12N5/10 , C12N15/13 , C12P21/08 , C12R1/91 , A61K35/16 , A61K39/00
CPC分类号: C07K16/2806 , A61K38/00 , C07K2317/24 , Y10S530/867
摘要: A humanised antibody is provided in which the amino acid sequence of the CDRs is derived from the sequence of CDRs of a monoclonal antibody having the specificity of binding to resting and activated T-cells, inhibiting T-cell proliferation and lysing T-cells from mice transgenic for human CD2 and in which sufficient of the amino acid sequence of each CDR has been retained to provide the same specificity for the humanised antibody.
摘要翻译: PCT No.PCT / GB92 / 02251 Sec。 371日期:1994年6月3日 102(e)日期1994年6月3日PCT提交1992年12月4日PCT公布。 公开号WO93 / 11237 日期:1993年6月10日。提供了人源化抗体,其中CDR的氨基酸序列衍生自具有结合静息和活化T细胞的特异性的单克隆抗体的CDR序列,抑制T细胞增殖 以及从对于人CD2转基因的小鼠中裂解T细胞,并且其中保留了足够的每个CDR的氨基酸序列以提供与人源化抗体相同的特异性。
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