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公开(公告)号：US07247313B2
公开(公告)日：2007-07-24
申请号：US10176504
申请日：2002-06-21
申请人： Wouter E. Roorda , Ni Ding , Stephen D. Pacetti , Eugene T. Michal , Ashok A. Shah , Syed F. A. Hossainy
发明人： Wouter E. Roorda , Ni Ding , Stephen D. Pacetti , Eugene T. Michal , Ashok A. Shah , Syed F. A. Hossainy
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , C08L33/10 , C08L33/06
摘要： A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polyacrylate, a blend of polyacrylates, or a blend of the polyacrylate with other polymers, for example, poly(ethylene-co-vinyl alcohol).
摘要翻译： 描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。 涂层可以包括聚丙烯酸酯，聚丙烯酸酯的共混物或聚丙烯酸酯与其它聚合物的共混物，例如聚（乙烯 - 共 - 乙烯醇）。
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2.发明授权Polycationic peptide coatings and methods of coating implantable medical devices 失效聚阳离子肽涂层和涂覆可植入医疗器械的方法公开(公告)号：US07033602B1
公开(公告)日：2006-04-25
申请号：US10177116
申请日：2002-06-21
IPC分类号： A61F2/02
CPC分类号： A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
摘要： Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.
摘要翻译： 公开了包括聚阳离子肽如L-精氨酸的医疗器械用涂层和制造涂层的方法。
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公开(公告)号：US07955615B2
公开(公告)日：2011-06-07
申请号：US11212376
申请日：2005-08-26
IPC分类号： A61F2/04
CPC分类号： A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
摘要： Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.
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4.发明授权Polycationic peptide coatings and methods of coating implantable medical devices 有权聚阳离子肽涂层和涂覆可植入医疗器械的方法公开(公告)号：US07875286B2
公开(公告)日：2011-01-25
申请号：US11213290
申请日：2005-08-26
IPC分类号： A61F2/02
CPC分类号： A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
摘要： Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.
摘要翻译： 公开了包括聚阳离子肽如L-精氨酸的医疗器械用涂层和制造涂层的方法。
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5.发明授权Polycationic peptide coatings and methods of coating implantable medical devices 有权聚阳离子肽涂层和涂覆可植入医疗器械的方法公开(公告)号：US07803406B2
公开(公告)日：2010-09-28
申请号：US11213288
申请日：2005-08-26
IPC分类号： A61K9/50
CPC分类号： A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
摘要： Methods of forming coatings comprising a polycationic peptide for medical devices are disclosed. Also disclosed is a coating comprising a polycationic peptide.
摘要翻译： 公开了形成包含用于医疗装置的聚阳离子肽的涂层的方法。 还公开了包含聚阳离子肽的涂层。
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6.发明授权Rate limiting barriers for implantable devices and methods for fabrication thereof 有权用于可植入装置的速率限制障碍及其制造方法公开(公告)号：US07175873B1
公开(公告)日：2007-02-13
申请号：US10198898
申请日：2002-07-18
IPC分类号： A61L33/10
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.
摘要翻译： 公开了一种涂覆可植入医疗装置（例如支架）的方法。 该方法包括在含有治疗物质的第一聚合物层上施用制剂以形成第二层。 制剂可以含有高度疏水性的聚合物或作为第一层药物或聚合物的不良溶剂的溶剂。 制剂可以具有低表面张力值或高Weber数值。
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7.发明授权Rate limiting barriers for implantable devices and methods for fabrication thereof 有权用于可植入装置的速率限制障碍及其制造方法公开(公告)号：US07622146B2
公开(公告)日：2009-11-24
申请号：US11592632
申请日：2006-11-02
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2420/02 , A61L2420/08
摘要： A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.
摘要翻译： 公开了一种涂覆可植入医疗装置（例如支架）的方法。 该方法包括在含有治疗物质的第一聚合物层上施用制剂以形成第二层。 制剂可以含有高度疏水性的聚合物或作为第一层的药物或聚合物的不良溶剂的溶剂。 制剂可以具有低表面张力值或高Weber数值。
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8.发明授权公开(公告)号：US07285304B1
公开(公告)日：2007-10-23
申请号：US10603889
申请日：2003-06-25
申请人： Syed F. A. Hossainy , Ni Ding , Stephen D. Pacetti
发明人： Syed F. A. Hossainy , Ni Ding , Stephen D. Pacetti
IPC分类号： A61L33/00
CPC分类号： A61L31/10 , A61F2/91 , A61F2210/0004 , Y10S623/901
摘要： A method of manufacturing an implantable medical device including applying a composition to an implantable medical device, the composition including a polymer, an active agent and a solvent; allowing the solvent to evaporate to form a dry coating, the dry coating comprising less than about 2% residual fluid content (w/w); applying a fluid to the dry coating, the fluid being substantially free from any polymer; and allowing the fluid to evaporate from the coating.
摘要翻译： 一种制造可植入医疗装置的方法，包括将组合物施用于可植入医疗装置，所述组合物包括聚合物，活性剂和溶剂; 允许溶剂蒸发以形成干燥涂层，干涂层包含小于约2％的残留流体含量（w / w）; 将流体施加到干燥涂层，所述流体基本上不含任何聚合物; 并允许流体从涂层蒸发。
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公开(公告)号：US20090136556A1
公开(公告)日：2009-05-28
申请号：US12363538
申请日：2009-01-30
申请人： Stephen D. Pacetti , Wouter E. Roorda , Ni Ding
发明人： Stephen D. Pacetti , Wouter E. Roorda , Ni Ding
CPC分类号： B05D3/0466 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D3/0473 , B05D3/048 , Y10T428/1393 , Y10T428/31507 , Y10T428/31551 , Y10T428/31725 , Y10T428/31786 , Y10T428/31855
摘要： A method and system of coating an implantable device, such as a stent, are provided.
摘要翻译： 提供涂覆可植入装置（例如支架）的方法和系统。
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10.发明授权Medicated coatings for implantable medical devices having controlled rate of release 有权具有受控释放速率的可植入医疗器械的药物涂层公开(公告)号：US07875285B1
公开(公告)日：2011-01-25
申请号：US10619727
申请日：2003-07-15
申请人： Wouter E. Roorda , Ni Ding , Stephen D. Pacetti
发明人： Wouter E. Roorda , Ni Ding , Stephen D. Pacetti
IPC分类号： A61F2/02
CPC分类号： A61L31/10 , A61F2/82 , A61F2250/0067 , A61L31/16
摘要： A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polymer having in a dry state a glass transition temperature within a range of between about 20° C. and about 55° C.
摘要翻译： 描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。 涂层可以包括在干燥状态下的玻璃化转变温度在约20℃至约55℃的范围内的聚合物。
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