-
公开(公告)号:US07160915B2
公开(公告)日:2007-01-09
申请号:US10897464
申请日:2004-07-22
申请人: Stephen Douglas Barrett , Cathlin Marie Flamme , Michael David Kaufman , Jared Bruce John Milbank , Haile Tecle , Joseph Scott Warmus
发明人: Stephen Douglas Barrett , Cathlin Marie Flamme , Michael David Kaufman , Jared Bruce John Milbank , Haile Tecle , Joseph Scott Warmus
IPC分类号: A61K31/4184 , C07D235/22 , C07D235/06
CPC分类号: C07D235/06 , C07D235/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/04
摘要: The present invention relates to N-methyl-substituted benzamidazole derivatives of formula (I): as defined in the specification; pharmaceutical compositions and methods of use thereof.
摘要翻译: 本发明涉及式(I)的N-甲基取代的苯甲胺唑衍生物:如说明书中所定义; 药物组合物及其使用方法。
-
公开(公告)号:US07411001B2
公开(公告)日:2008-08-12
申请号:US11102307
申请日:2005-04-07
申请人: Stephen Douglas Barrett , Cathlin Marie Biwersi , Michael Huai Gu Chen , Michael David Kaufman , Haile Tecle , Joseph Scott Warmus
发明人: Stephen Douglas Barrett , Cathlin Marie Biwersi , Michael Huai Gu Chen , Michael David Kaufman , Haile Tecle , Joseph Scott Warmus
IPC分类号: A61K31/215 , C07C239/00
CPC分类号: C07D261/02 , C07C259/10 , C07C271/16 , C07C2601/02 , C07D295/088 , C07D317/18 , C07D319/06
摘要: The present invention relates to oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof. The present invention also relates to crystalline forms of oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
摘要翻译: 本发明涉及4-碘苯基氨基苯并肟酸衍生物的氧化酯,药物组合物及其使用方法。 本发明还涉及4-碘苯基氨基苯并肟酸衍生物的氧化酯的结晶形式,药物组合物及其使用方法。
-
公开(公告)号:US06960614B2
公开(公告)日:2005-11-01
申请号:US10333399
申请日:2001-07-12
申请人: Stephen Douglas Barrett , Cathlin Marie Biwersi , Michael David Kaufman , Haile Tecle , Joseph Scott Warmus
发明人: Stephen Douglas Barrett , Cathlin Marie Biwersi , Michael David Kaufman , Haile Tecle , Joseph Scott Warmus
IPC分类号: C07D261/12 , A61K31/337 , A61K31/42 , A61K31/475 , A61K45/00 , A61K51/00 , A61P9/10 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/04 , A61P29/00 , A61P31/12 , A61P35/00 , C07C259/00 , C07C259/10 , C07D261/02 , C07D295/088 , C07D317/18 , C07D319/06 , A61K31/215 , C07C239/00
CPC分类号: C07D261/02 , C07C259/10 , C07C271/16 , C07C2601/02 , C07D295/088 , C07D317/18 , C07D319/06
摘要: The present invention relates to oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof. The present invention also relates to crystaline forms of oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
摘要翻译: 本发明涉及4-碘苯基氨基苯并肟酸衍生物的氧化酯,药物组合物及其使用方法。 本发明还涉及4-碘苯基氨基苯并肟酸衍生物的氧化酯的结晶形式,药物组合物及其使用方法。
-
公开(公告)号:US07001905B2
公开(公告)日:2006-02-21
申请号:US10221522
申请日:2001-03-12
IPC分类号: C07D265/22 , C07C237/30 , C07C237/32 , A61K31/536 , A61K31/166
CPC分类号: C07C237/30 , C07C237/32 , C07C237/34 , C07C259/10 , C07C2601/02 , C07C2601/14 , C07D265/22 , C07D295/13 , C07D295/192 , C07D295/26 , C07D413/12
摘要: Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C1-6 alkoxy, or NR6OR7; X is OR12, NR13R12, or NR14; inhibitors of MEK and are useful in the treatment of a variety of proliferative disease states, such as conditions related to the hyperactivity of MEK, as well as diseases modulated by the MEK cascade.
摘要翻译: 二芳基胺,例如式(I)或式(II)的5-酰胺取代的二芳基胺,其中A是羟基,C 1-6烷氧基或NR 6或 > 7 SUB>; X是OR 12,NR 13 R 12或NR 14; MEK抑制剂可用于治疗各种增生性疾病状态,例如与MEK的多动症有关的病症以及由MEK级联调节的疾病。
-
公开(公告)号:US5919790A
公开(公告)日:1999-07-06
申请号:US942605
申请日:1997-10-02
申请人: Hamish John Allen , Kenneth Dale Brady , Bradley William Caprathe , Paul Galatsis , John Lodge Gilmore , Sheryl Jeanne Hays , Robert Vincent Talanian , Nigel Walker , Joseph Scott Warmus
发明人: Hamish John Allen , Kenneth Dale Brady , Bradley William Caprathe , Paul Galatsis , John Lodge Gilmore , Sheryl Jeanne Hays , Robert Vincent Talanian , Nigel Walker , Joseph Scott Warmus
IPC分类号: C07C259/06 , C07C271/22 , C07C271/64 , C07D207/46 , C07D209/34 , C07D491/18 , A61K31/405 , A61K31/44 , C07C229/32 , C07C259/08 , C07D209/46 , C07D209/48 , C07D221/20
CPC分类号: C07C271/22 , C07C259/06 , C07C271/64 , C07D207/46 , C07D209/34
摘要: The present invention relates to compounds that are inhibitors of interleukin-1.beta. converting enzyme that have the Formula II ##STR1## This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock, reperfusion injury, Alzheimer's disease, shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1.beta. converting enzyme.
摘要翻译: 本发明涉及具有式II的白细胞介素-1β转换酶抑制剂的化合物本发明还涉及治疗中风,炎性疾病,败血性休克,再灌注损伤,阿尔茨海默病,志贺氏菌病的方法,以及 含有作为白细胞介素-1β转换酶抑制剂的化合物的药学上可接受的组合物。
-
-
-
-