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公开(公告)号：USD496608S1
公开(公告)日：2004-09-28
申请号：US29172124
申请日：2002-12-06
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公开(公告)号：USD506953S1
公开(公告)日：2005-07-05
申请号：US29172096
申请日：2002-12-06
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公开(公告)号：USD520410S1
公开(公告)日：2006-05-09
申请号：US29172121
申请日：2002-12-06
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公开(公告)号：US20100267937A1
公开(公告)日：2010-10-21
申请号：US12828391
申请日：2010-07-01
IPC分类号： C07K16/00 , C07D403/06 , C07D209/10 , C07H19/10 , C07H21/04
CPC分类号： C09B23/02 , C07D209/10 , C07D209/24 , C07D403/06 , C07D403/08
摘要： Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which groups R3 and R4 are attached to the Z1 ring structure and groups R5 and R6 are attached to the Z2 ring structure, and n=1, 2 or 3; Z1 and Z2 independently represent the carbon atoms necessary to complete a one ring, or two-fused ring aromatic system; at least one of groups R1, R2, R3, R4, R5, R6 and R7 is the group -E-F where E is a single bond or a spacer group and F is a target bonding group; one or more of groups R11, R12, R13 and R14 are independently selected from the group —(CH2)k—W, where W is sulphonic acid or phosphonic acid and k is an integer from 1 to 10. The dyes may be used in fluorescence labelling applications, where the presence of one and preferably multiple water solubilising groups attached to the 3-position of the indolinium ring reduces dye-dye interactions, and hence dye-dye quenching, particularly where multiple dye molecules are attached to components such as nucleic acids, oligonucleotides, proteins and antibodies.
摘要翻译： 公开了可用于标记和检测生物和其他材料的花青染料。 染料具有式（I）：其中基团R 3和R 4连接到Z 1环结构，并且基团R 5和R 6连接到Z 2环结构，并且n = 1,2或3; Z 1和Z 2独立地表示完成一个环或双稠环芳族体系所必需的碳原子; 基团R 1，R 2，R 3，R 4，R 5，R 6和R 7中的至少一个是基团-E-F，其中E是单键或间隔基，F是目标键合基团; 基团R11，R12，R13和R14中的一个或多个独立地选自基团 - （CH 2）k-W，其中W是磺酸或膦酸，k是1至10的整数。染料可以用于 荧光标记应用，其中连接到吲哚啉环的3-位上的一个并且优选多个水溶性基团的存在降低了染料 - 染料相互作用，并因此染色剂猝灭，特别是当多个染料分子连接到组分如核酸 酸，寡核苷酸，蛋白质和抗体。
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5.发明授权Method for investigating the fate of a test compound or the stateof a biological system by means of NMR of hyperpolarised NMR active nuclei 有权通过超极化NMR活性核的NMR研究试验化合物的命运或生物体系的状态的方法公开(公告)号：US08372654B2
公开(公告)日：2013-02-12
申请号：US10311108
申请日：2001-06-12
申请人： Neil Cook , Albie Santos , Nigel Bosworth , Jan Wolber , Mike Looker , Peter Knox , Jan Jenrik Ardenkjaer-Larsen , Klaes Golman
发明人： Neil Cook , Albie Santos , Nigel Bosworth , Jan Wolber , Mike Looker , Peter Knox , Jan Jenrik Ardenkjaer-Larsen , Klaes Golman
IPC分类号： G01N1/00
CPC分类号： G01R33/465 , A61K49/10 , G01N33/5088 , G01R33/5601 , G01R33/62 , Y10T436/24 , Y10T436/25
摘要： The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarization methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionally employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.
摘要翻译： 本发明涉及核磁共振（NMR）光谱和磁共振成像（MRI），特别是NMR光谱。 它提供超极化方法，提供检测与常规NMR的灵敏度，以研究生物系统中测试化合物的命运。 该方法特别适用于研究药物的代谢和毒性。 所得的NMR灵敏度增加在NMR检测的两个关键方面是有利的：可以以较低的浓度检测测试化合物，并且在通常采用广泛平均以提高相应NMR光谱的信噪比的情况下可以实现显着的时间节省 。 该方法可用于使用常规NMR不实用或不可能的工作室。
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公开(公告)号：US5658494A
公开(公告)日：1997-08-19
申请号：US445858
申请日：1995-05-22
摘要： Novel compounds obtainable by reacting together an imido-reagent such as diphenylphosphonimido-triphenylphosphorane), or a phosphine oxide such as p-tolyldiphenylphosphine oxide, with a chelate of a transition or lanthanide or actinide metal, such as tris(dibenzoylmethide)europium III, have the property of fluorescing in UV radiation. The invention includes solid polymer bodies containing such compounds, or chelates of transition or lanthanide or actinide metals generally, the bodies having the property of emitting light or infra-red radiation when subjected to a flux of ultra-violet or ionising radiation by virtue of internally generated, e.g. by tritium ionising radiation. The body is preferably of polystyrene formed by polymerising the monomer in the presence of the compound or metal chelate.
摘要翻译： 通过使亚氨基试剂如二苯基亚膦酰基 - 三苯基正膦或其氧化膦如对甲苯基二苯基氧化膦与过渡或镧系元素或锕系金属螯合物如三（二苯甲酰甲基）铕III的螯合物反应得到的新型化合物具有三 在紫外线辐射下发荧光的特性。 本发明包括含有这些化合物的固体聚合物体，或过渡或镧系元素或锕系金属的螯合物，通常通过内部经受紫外或电离辐射的通量而具有发射光或红外辐射性质的物质 生成，例如 通过氚电离辐射。 身体优选是通过在化合物或金属螯合物的存在下聚合单体而形成的聚苯乙烯。
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公开(公告)号：US08148539B2
公开(公告)日：2012-04-03
申请号：US12828391
申请日：2010-07-01
IPC分类号： C07D277/60
CPC分类号： C09B23/02 , C07D209/10 , C07D209/24 , C07D403/06 , C07D403/08
摘要： Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which groups R3 and R4 are attached to the Z1 ring structure and groups R5 and R6 are attached to the Z2 ring structure, and n=1, 2 or 3; Z1 and Z2 independently represent the carbon atoms necessary to complete a one ring, or two-fused ring aromatic system; at least one of groups R1, R2, R3, R4, R5, R6 and R7 is the group -E-F where E is a single bond or a spacer group and F is a target bonding group; one or more of groups R11, R12, R13 and R14 are independently selected from the group —(CH2)k—W, where W is sulphonic acid or phosphonic acid and k is an integer from 1 to 10. The dyes may be used in fluorescence labelling applications, where the presence of one and preferably multiple water solubilizing groups attached to the 3-position of the indolinium ring reduces dye-dye interactions, and hence dye-dye quenching, particularly where multiple dye molecules are attached to components such as nucleic acids, oligonucleotides, proteins and antibodies.
摘要翻译： 公开了可用于标记和检测生物和其他材料的花青染料。 染料具有式（I）：其中基团R 3和R 4连接到Z 1环结构，并且基团R 5和R 6连接到Z 2环结构，并且n = 1,2或3; Z 1和Z 2独立地表示完成一个环或双稠环芳族体系所必需的碳原子; 基团R 1，R 2，R 3，R 4，R 5，R 6和R 7中的至少一个是基团-E-F，其中E是单键或间隔基，F是目标键合基团; 基团R11，R12，R13和R14中的一个或多个独立地选自基团 - （CH 2）k-W，其中W是磺酸或膦酸，k是1至10的整数。染料可以用于 荧光标记应用，其中连接到吲哚啉环的3-位上的一个优选多个水溶性基团的存在降低了染料 - 染料相互作用，因此染料猝灭，特别是当多个染料分子连接到组分如核酸 酸，寡核苷酸，蛋白质和抗体。
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公开(公告)号：US07750163B2
公开(公告)日：2010-07-06
申请号：US10576956
申请日：2004-10-29
IPC分类号： C07D277/60
CPC分类号： C09B23/02 , C07D209/10 , C07D209/24 , C07D403/06 , C07D403/08
摘要： Disclosed are cyanine dyes that are useful for labeling and detecting biological and other materials. The dyes are of formula (I) in which groups R3 and R4 are attached to the Z1 ring structure and groups R5 and R6 are attached to the Z2 ring structure, and n=1, 2 or 3; Z1 and Z2 independently represent the carbon atoms necessary to complete a one ring, or two-fused ring aromatic system; at least one of groups R1, R2, R3, R4, R5, R6 and R7 is the group -E-F where E is a single bond or a spacer group and F is a target bonding group; one or more of groups R11, R12, R13 and R14 are independently selected from the group —(CH2)k—W, where W is sulphonic acid or phosphonic acid and k is an integer from 1 to 10. The dyes may be used in fluorescence labeling applications, where the presence of one and preferably multiple water solubilising groups attached to the 3-position of the indolinium ring reduces dye-dye interactions, and hence dye-dye quenching, particularly where multiple dye molecules are attached to components such as nucleic acids, oligonucleotides, proteins and antibodies.
摘要翻译： 公开了可用于标记和检测生物和其他材料的花青染料。 染料具有式（I），其中基团R 3和R 4连接到Z 1环结构，并且基团R 5和R 6连接到Z 2环结构，并且n = 1,2或3; Z 1和Z 2独立地表示完成一个环或双稠环芳族体系所必需的碳原子; 基团R 1，R 2，R 3，R 4，R 5，R 6和R 7中的至少一个是基团-E-F，其中E是单键或间隔基，F是目标键合基团; 基团R11，R12，R13和R14中的一个或多个独立地选自基团 - （CH 2）k-W，其中W是磺酸或膦酸，k是1至10的整数。染料可以用于 荧光标记应用，其中连接到吲哚啉环的3-位上的一个并且优选多个水溶性基团的存在降低了染料 - 染料相互作用，并因此染色剂猝灭，特别是当多个染料分子连接到组分如核酸 酸，寡核苷酸，蛋白质和抗体。
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公开(公告)号：US06828116B1
公开(公告)日：2004-12-07
申请号：US09719016
申请日：2001-02-15
IPC分类号： C12Q137
CPC分类号： G01N33/533 , C07H21/00 , C09B23/02 , G01N33/542 , Y10S435/968
摘要： Disclosed is a non-fluorescent cyanine dye that may be used as an acceptor in fluorescence energy transfer assays involving the detection of binding and/or cleavage events in reactions involving biological molecules, and assay methods utilising such dyes. The non-fluorescent cyanine dye is a compound of formula (I), wherein the linker group Q contains at least one double bond and forms a conjugated system with the rings containing X and Y; groups R3, R4, R5 and R6 are attached to the rings containing X and Y, or optionally, are attached to atoms of the Z1 and Z2 ring structures; Z1 and Z2 each represent a bond or the atoms necessary to complete one or two fused aromatic rings each ring having five or six atoms, selected from carbon atoms and, optionally, no more than two oxygen, nitrogen and sulphur atoms; at least one of groups R1, R2, R3, R4, R5, R6and R7 is a target bonding group; any remaining groups R3, R4, R5, R6 and R7 groups are independently selected from the group consisting of hydrogen, C1-C4 alkyl, OR9, COOR9, nitro, amino, acylamino, quaternary ammonium, phosphate sulphonate and sulphate, where R9 is selected from H and C1-C4 alkyl; any remaining R1 and R2 are selected from C1-C10 alkyl which may be unsubstituted or substituted with phenyl, the phenyl being optionally substituted by up to two substituents selected from carboxyl, sulphonate and nitro groups; characterised in that at least one of the groups R1, R2, R3, R4, R5, R6 and R7 comprises a substituent which reduces the fluorescence emission of said dye such that it is essentially non-fluorescent.
摘要翻译： 公开了一种非荧光花青染料，其可用作荧光能量转移测定中的受体，涉及检测涉及生物分子的反应中的结合和/或切割事件，以及使用这种染料的测定方法。 非荧光花青染料是式（I）化合物，其中连接基团Q含有至少一个双键并与含有X和Y的环形成共轭体系; 基团R 3，R 4，R 5和R 6连接到含有X和Y的环上，或任选地连接到Z 1和Z 2环结构的原子上 ; Z 1和Z 2各自表示一个键或完成一个或两个稠合芳环所必需的原子，每个环具有五个或六个原子，选自碳原子和任选不超过两个氧，氮和硫 原子 基团R 1，R 2，R 3，R 4，R 5，R 6和R 7中的至少一个是目标键合基团; 任何剩余的基团R 3，R 4，R 5，R 6和R 7基团独立地选自氢，C 1 -C 4烷基，OR 9， 9，硝基，氨基，酰氨基，季铵，磷酸酯磺酸盐和硫酸盐，其中R 9选自H和C 1 -C 4烷基; 任何剩余的R 1和R 2选自可以是未取代的或被苯基取代的C 1 -C 10烷基，所述苯基任选被至多两个选自羧基，磺酸根和硝基的取代基取代; 其特征在于R 1，R 2，R 3，R 4，R 5，R 6和R 7基团中的至少一个包含降低荧光的取代基 所述染料的发射使得其基本上不发荧光。
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公开(公告)号：US20210252691A1
公开(公告)日：2021-08-19
申请号：US17178451
申请日：2021-02-18
申请人： Nigel Bosworth
发明人： Nigel Bosworth
摘要： A storage device for storing cable ties or the like has a plurality of adjacent compartments extending in an axial direction parallel to one another. Retaining members in the form of magnets are provided on side walls of the compartments for releasably holding the device to a supporting structure in use. The compartments each have an open end to allow insertion of the cable tie and a closed end. The compartments have different axial lengths to accommodate different lengths of cable ties. The storage device may be releasably applied to the side of a tool chest or the like.
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