公开(公告)号：US20050208626A1

公开(公告)日：2005-09-22

申请号：US11133912

申请日：2005-05-19

申请人： Paul Sheppard ,  Stephen Jaspers ,  Theresa Deisher ,  Paul Bishop

发明人： Paul Sheppard ,  Stephen Jaspers ,  Theresa Deisher ,  Paul Bishop

IPC分类号： A61K38/00 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/575 ,  C07K14/63

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K14/47 ,  C07K14/575 ,  C07K14/63

摘要： The present invention is directed to polynucleotides, polypeptides, peptides, variants and uses thereof for novel peptide fragments which have homology to motilin. Tissue distribution of the mRNA for the novel polypeptide fragment is specific to the stomach, small intestine and pancreas. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies and host cells expressing the cDNA encoding the novel SGIP peptide.

摘要翻译： 本发明涉及与胃动素同源的新型肽片段的多核苷酸，多肽，肽，变体和用途。 新型多肽片段的mRNA的组织分布特异于胃，小肠和胰腺。 肽片段的结合已显示在肾脏和小肠中。 本发明还包括表达编码新型SGIP肽的cDNA的激动剂，拮抗剂，变体，抗体和宿主细胞。

公开(公告)号：US20050106146A1

公开(公告)日：2005-05-19

申请号：US10927484

申请日：2004-08-25

申请人： Paul Sheppard ,  Theresa Deisher ,  Paul Bishop ,  Stephen Jaspers ,  Virender Labroo

发明人： Paul Sheppard ,  Theresa Deisher ,  Paul Bishop ,  Stephen Jaspers ,  Virender Labroo

IPC分类号： A61K38/00 ,  C07K14/575 ,  A61K39/395 ,  C07K16/26

CPC分类号： C07K14/575 ,  A61K38/00

摘要： The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.

摘要翻译： 本发明涉及多核苷酸，多肽及其肽片段及其与胃动素同源性的新cDNA序列的用途。 新型多肽的mRNA的组织分布特异于胃，小肠和胰腺。 本发明还包括激动剂，拮抗剂，抗体，表达编码新型胃动素同系物的cDNA的宿主细胞和使用新分子增加胃动力的方法。

公开(公告)号：US20050048618A1

公开(公告)日：2005-03-03

申请号：US10921371

申请日：2004-08-19

申请人： Stephen Jaspers ,  Paul Sheppard ,  Theresa Deisher ,  Paul Bishop

发明人： Stephen Jaspers ,  Paul Sheppard ,  Theresa Deisher ,  Paul Bishop

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K14/63 ,  C07H21/04 ,  C07K14/705

CPC分类号： C07K14/63 ,  A61K38/00 ,  C07K14/575

摘要： The present invention relates to polynucleotide related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.

摘要翻译： 本发明涉及到有关的zsig33肽，包括激动剂，拮抗剂，和抗体的多核苷酸。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。

公开(公告)号：US20060024805A1

公开(公告)日：2006-02-02

申请号：US11242243

申请日：2005-10-03

申请人： Paul Sheppard ,  Nand Baindur ,  Theresa Deisher ,  Paul Bishop ,  David Taft

发明人： Paul Sheppard ,  Nand Baindur ,  Theresa Deisher ,  Paul Bishop ,  David Taft

IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N9/00

CPC分类号： C12N9/6489 ,  C07K14/47

摘要： The present invention relates to polynucleotide and polypeptide molecules for zdint1, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are believed to be cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the zdint1 polypeptides.

公开(公告)号：US20070042417A1

公开(公告)日：2007-02-22

申请号：US11549232

申请日：2006-10-13

申请人： PAUL SHEPPARD ,  Paul Bishop ,  Theodore Whitmore ,  Penny Thompson

发明人： PAUL SHEPPARD ,  Paul Bishop ,  Theodore Whitmore ,  Penny Thompson

IPC分类号： C12Q1/68

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/4702 ,  C07K2319/00 ,  C12Q1/6888 ,  C12Q2600/158

摘要： The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The invention also provides methods for using the antibodies to detect the presence of the protein with antibodies and methods for using the polynucleotides to detect the presence of Zven RNA.

摘要翻译： 本发明提供新的用途，称为“Zven”的新家族人类蛋白质的两个成员，作为刺激胃肠收缩力，胃排空，肠道运输和治疗胃轻瘫的药物。位于人染色体3p21.1中的Zven1基因 -3p14.3，表达于睾丸组织和外周血淋巴细胞。 本发明还提供了使用抗体检测蛋白质与抗体的方法以及使用多核苷酸检测Zven RNA的存在的方法。

公开(公告)号：US20070048840A1

公开(公告)日：2007-03-01

申请号：US11549222

申请日：2006-10-13

申请人： Paul Sheppard ,  Paul Bishop ,  Theodore Whitmore ,  Penny Thompson

发明人： Paul Sheppard ,  Paul Bishop ,  Theodore Whitmore ,  Penny Thompson

IPC分类号： C12P21/02 ,  C12N1/21 ,  C12N1/18 ,  C07K14/52 ,  C12N5/04 ,  C12N5/06

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/4702 ,  C07K2319/00 ,  C12Q1/6888 ,  C12Q2600/158

摘要： The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1 - 3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The invention also provides methods for using the antibodies to detect the presence of the protein with antibodies and methods for using the polynucleotides to detect the presence of Zven RNA.

摘要翻译： 本发明提供新的用途，称为“Zven”的新家族人类蛋白质的两个成员，作为刺激胃肠收缩力，胃排空，肠道运输和治疗胃轻瘫的药物。位于人染色体3p21.1中的Zven1基因 3p14.3，表达于睾丸组织和外周血淋巴细胞。 本发明还提供了使用抗体检测蛋白质与抗体的方法以及使用多核苷酸检测Zven RNA的存在的方法。

公开(公告)号：US20070048805A1

公开(公告)日：2007-03-01

申请号：US11549237

申请日：2006-10-13

申请人： PAUL SHEPPARD ,  Paul Bishop ,  Theodore Whitmore ,  Penny Thompson

发明人： PAUL SHEPPARD ,  Paul Bishop ,  Theodore Whitmore ,  Penny Thompson

IPC分类号： G01N33/567

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/4702 ,  C07K2319/00 ,  C12Q1/6888 ,  C12Q2600/158

摘要： The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The invention also provides methods for using the antibodies to detect the presence of the protein with antibodies and methods for using the polynucleotides to detect the presence of Zven RNA.

摘要翻译： 本发明提供新的用途，称为“Zven”的新家族人类蛋白质的两个成员，作为刺激胃肠收缩力，胃排空，肠道运输和治疗胃轻瘫的药物。位于人染色体3p21.1中的Zven1基因 -3p14.3，表达于睾丸组织和外周血淋巴细胞。 本发明还提供了使用抗体检测蛋白质与抗体的方法以及使用多核苷酸检测Zven RNA的存在的方法。

公开(公告)号：US20070042960A1

公开(公告)日：2007-02-22

申请号：US11549227

申请日：2006-10-13

申请人： PAUL SHEPPARD ,  Paul Bishop ,  Theodore Whitmore ,  Penny Thompson

发明人： PAUL SHEPPARD ,  Paul Bishop ,  Theodore Whitmore ,  Penny Thompson

IPC分类号： A61K38/22

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/4702 ,  C07K2319/00 ,  C12Q1/6888 ,  C12Q2600/158

摘要： The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The invention also provides methods for using the antibodies to detect the presence of the protein with antibodies and methods for using the polynucleotides to detect the presence of Zven RNA.

摘要翻译： 本发明提供新的用途，称为“Zven”的新家族人类蛋白质的两个成员，作为刺激胃肠道收缩性，胃排空，肠道转运和治疗胃轻瘫的药物。位于人染色体3p21.1中的Zven1基因 -3p14.3，表达于睾丸组织和外周血淋巴细胞。 本发明还提供了使用抗体检测蛋白质与抗体的方法以及使用多核苷酸检测Zven RNA的存在的方法。

公开(公告)号：US20050214800A1

公开(公告)日：2005-09-29

申请号：US10982168

申请日：2004-11-05

申请人： Paul Sheppard ,  Paul Bishop

发明人： Paul Sheppard ,  Paul Bishop

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/705 ,  C12N15/09

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/4702 ,  C07K2319/00 ,  C12Q1/6888 ,  C12Q2600/158

摘要： The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.

摘要翻译： 本发明提供了两个称为“Zven”的人类蛋白质家族的成员。 位于人染色体3p21.1-3p14.3中的Zven1基因在睾丸组织和外周血淋巴细胞中表达。

公开(公告)号：US20070172889A1

公开(公告)日：2007-07-26

申请号：US11549241

申请日：2006-10-13

申请人： PAUL SHEPPARD ,  Paul Bishop ,  Theodore Whitmore ,  Penny Thompson

发明人： PAUL SHEPPARD ,  Paul Bishop ,  Theodore Whitmore ,  Penny Thompson

IPC分类号： C07K14/575 ,  G01N33/53

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/4702 ,  C07K2319/00 ,  C12Q1/6888 ,  C12Q2600/158

摘要： The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The invention also provides methods for using the antibodies to detect the presence of the protein with antibodies and methods for using the polynucleotides to detect the presence of Zven RNA.

摘要翻译： 本发明提供新的用途，称为“Zven”的新家族人类蛋白质的两个成员，作为刺激胃肠收缩力，胃排空，肠道运输和治疗胃轻瘫的药物。位于人染色体3p21.1中的Zven1基因 -3p14.3，表达于睾丸组织和外周血淋巴细胞。 本发明还提供了使用抗体检测蛋白质与抗体的方法以及使用多核苷酸检测Zven RNA的存在的方法。