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    Identification of biomarkers for liver toxicity
    1.
    发明授权
    Identification of biomarkers for liver toxicity 有权
    鉴定肝毒性的生物标志物

    公开(公告)号：US07452678B2

    公开(公告)日：2008-11-18

    申请号：US10873595

    申请日：2004-06-22

    申请人： Stephen K. Durham ,  Donna Dambach ,  Stanley Hefta ,  Frederic Moulin ,  Ji Gao ,  Gregory Opiteck ,  Stephen M. Storm ,  Leah Ann Garulacan ,  Jun-Hsiang Lin

    发明人： Stephen K. Durham ,  Donna Dambach ,  Stanley Hefta ,  Frederic Moulin ,  Ji Gao ,  Gregory Opiteck ,  Stephen M. Storm ,  Leah Ann Garulacan ,  Jun-Hsiang Lin

    IPC分类号： G01N33/53

    CPC分类号： G01N33/5014 ,  G01N33/576

    摘要： The present invention relates to biomarker polypeptides, polynucleotides, and antibodies that have utility in predicting in vitro and/or in vivo hepatotoxicity of various drugs, compounds, or other therapeutic agents (i.e., test substances). Also related are screens, kits, microarrays, and cell culture systems that employ the polypeptides, polynucleotides, and/or antibodies of the invention. The reagents and methods of the invention are useful for predicting hepatotoxic effects resulting from treatment with one or more test substances, and can be utilized before, after, or concurrently with pre-clinical, clinical, and/or post-clinical testing. In this way, the reagents and methods of the invention can be used to identify test substances or combinations of test substances that cause hepatic injury, including idiosyncratic hepatotoxicity, and thereby prevent medical complications (e.g., liver failure) resulting from such injury.

    摘要翻译： 本发明涉及可用于预测各种药物，化合物或其它治疗剂（即测试物质）的体外和/或体内肝毒性的生物标记多肽，多核苷酸和抗体。 还涉及使用本发明的多肽，多核苷酸和/或抗体的筛选，试剂盒，微阵列和细胞培养系统。 本发明的试剂和方法可用于预测用一种或多种测试物质治疗产生的肝毒性作用，并且可以在临床前，临床和/或临床后测试之前，之后或同时使用。 以这种方式，本发明的试剂和方法可以用于鉴定引起肝损伤（包括特异性肝毒性）的测试物质或测试物质的组合，从而防止由于这种损伤引起的医疗并发症（例如肝衰竭）。